DOI: 10.1101/gad.12.20.3156. <i>Fgf-10</i> is required for both limb and lung development and exhibits striking functional similarity to <i>Drosophila branchless</i>

Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless

10.1101/gad.12.20.3156

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

Fgf-10-deficient mice (Fgf-10−/−) were generated to determine the role(s) of Fgf-10 in vertebrate development. Limb bud initiation was abolished inFgf-10−/− mice. Strikingly,Fgf-10−/− fetuses continued to develop until birth, despite the complete absence of both fore- and hindlimbs. Fgf-10 is necessary for apical ectodermal ridge (AER) formation and acts epistatically upstream of Fgf-8, the earliest known AER marker in mice.Fgf-10−/− mice exhibited perinatal lethality associated with complete absence of lungs. Although tracheal development was normal, main-stem bronchial formation, as well as all subsequent pulmonary branching morphogenesis, was completely disrupted. The pulmonary phenotype ofFgf-10−/− mice is strikingly similar to that of the Drosophila mutant branchless, anFgf homolog.

Bibliography

Min, H., Danilenko, D. M., Scully, S. A., Bolon, B., Ring, B. D., Tarpley, J. E., DeRose, M., & Simonet, W. S. (1998). Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes & Development, 12(20), 3156â3161.

Authors 8

Hosung Min (first)
Dimitry M. Danilenko (additional)
Sheila A. Scully (additional)
Brad Bolon (additional)
Brian D. Ring (additional)
John E. Tarpley (additional)
Margaret DeRose (additional)
W. Scott Simonet (additional)

References 40 Referenced 748

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Dates

Type	When
Created	17 years, 6 months ago (Feb. 20, 2008, 5:52 p.m.)
Deposited	3 years, 9 months ago (Nov. 14, 2021, 10:23 p.m.)
Indexed	1 week, 2 days ago (Aug. 20, 2025, 9:03 a.m.)
Issued	26 years, 10 months ago (Oct. 15, 1998)
Published	26 years, 10 months ago (Oct. 15, 1998)
Published Online	26 years, 10 months ago (Oct. 15, 1998)
Published Print	26 years, 10 months ago (Oct. 15, 1998)

Funders 0

None

BibTeX

@article{Min_1998, title={Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless}, volume={12}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.12.20.3156}, DOI={10.1101/gad.12.20.3156}, number={20}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Min, Hosung and Danilenko, Dimitry M. and Scully, Sheila A. and Bolon, Brad and Ring, Brian D. and Tarpley, John E. and DeRose, Margaret and Simonet, W. Scott}, year={1998}, month=oct, pages={3156–3161} }

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