DOI: 10.1101/gad.12.11.1599. p107 is a suppressor of retinoblastoma development in pRb-deficient mice

p107 is a suppressor of retinoblastoma development in pRb-deficient mice

10.1101/gad.12.11.1599

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

Hemizygosity for the retinoblastoma gene RB in man strongly predisposes to retinoblastoma. In the mouse, however,Rb hemizygosity leaves the retina normal, whereas inRb−/− chimeras pRb-deficient retinoblasts undergo apoptosis. To test whether concomitant inactivation of the Rb-related gene p107 is required to unleash the oncogenic potential of pRb deficiency in the mouse retina, we inactivated both Rb and p107 by homologous recombination in embryonic stem cells and generated chimeric mice. Retinoblastomas were found in five out of seven adult pRb/p107-deficient chimeras. The retinal tumors showed amacrine cell differentiation, and therefore originated from cells committed to the inner but not the outer nuclear layer. Retinal lesions were already observed at embryonic day 17.5. At this stage, the primitive nuclear layer exhibited severe dysplasia, including rosette-like arrangements, and apoptosis. These findings provide formal proof for the role of loss of Rb in retinoblastoma development in the mouse and the first in vivo evidence that p107 can exert a tumor suppressor function.

Bibliography

Robanus-Maandag, E., Dekker, M., van der Valk, M., Carrozza, M.-L., Jeanny, J.-C., Dannenberg, J.-H., Berns, A., & te Riele, H. (1998). p107 is a suppressor of retinoblastoma development in pRb-deficientâmice. Genes & Development, 12(11), 1599â1609.

Authors 8

Els Robanus-Maandag (first)
Marleen Dekker (additional)
Martin van der Valk (additional)
Maria-Luisa Carrozza (additional)
Jean-Claude Jeanny (additional)
Jan-Hermen Dannenberg (additional)
Anton Berns (additional)
Hein te Riele (additional)

References 60 Referenced 255

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Dates

Type	When
Created	17 years, 6 months ago (Feb. 20, 2008, 5:15 p.m.)
Deposited	3 years, 9 months ago (Nov. 14, 2021, 10:15 p.m.)
Indexed	2 months, 2 weeks ago (June 11, 2025, 5:29 a.m.)
Issued	27 years, 2 months ago (June 1, 1998)
Published	27 years, 2 months ago (June 1, 1998)
Published Online	27 years, 2 months ago (June 1, 1998)
Published Print	27 years, 2 months ago (June 1, 1998)

Funders 0

None

BibTeX

@article{Robanus_Maandag_1998, title={p107 is a suppressor of retinoblastoma development in pRb-deficient mice}, volume={12}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.12.11.1599}, DOI={10.1101/gad.12.11.1599}, number={11}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Robanus-Maandag, Els and Dekker, Marleen and van der Valk, Martin and Carrozza, Maria-Luisa and Jeanny, Jean-Claude and Dannenberg, Jan-Hermen and Berns, Anton and te Riele, Hein}, year={1998}, month=jun, pages={1599–1609} }

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