DOI: 10.1101/gad.11.23.3182. sel-10, a negative regulator of lin-12 activity inCaenorhabditis elegans, encodes a member of the CDC4 family of proteins

sel-10, a negative regulator of lin-12 activity inCaenorhabditis elegans, encodes a member of the CDC4 family of proteins

10.1101/gad.11.23.3182

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

Mutations that influence lin-12 activity inCaenorhabditis elegans may identify conserved factors that regulate the activity of lin-12/Notch proteins. We describe genetic evidence indicating that sel-10 is a negative regulator of lin-12/Notch-mediated signaling in C. elegans. Sequence analysis shows that SEL-10 is a member of the CDC4 family of proteins and has a potential human ortholog. Coimmunoprecipitation data indicate that C. elegansSEL-10 complexes with LIN-12 and with murine Notch4. We propose that SEL-10 promotes the ubiquitin-mediated turnover of LIN-12/Notch proteins, and discuss potential roles for the regulation of lin-12/Notch activity bysel-10 in cell fate decisions and tumorigenesis.

Bibliography

Hubbard, E. J. A., Wu, G., Kitajewski, J., & Greenwald, I. (1997). sel-10, a negative regulator of lin-12 activity inCaenorhabditis elegans, encodes a member of the CDC4 family ofâproteins. Genes & Development, 11(23), 3182â3193.

Authors 4

E. Jane Albert Hubbard (first)
Guangyu Wu (additional)
Jan Kitajewski (additional)
Iva Greenwald (additional)

References 61 Referenced 190

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Dates

Type	When
Created	17 years, 6 months ago (Feb. 20, 2008, 5:15 p.m.)
Deposited	3 years, 9 months ago (Nov. 14, 2021, 10:11 p.m.)
Indexed	11 months, 1 week ago (Sept. 19, 2024, 11:11 a.m.)
Issued	27 years, 8 months ago (Dec. 1, 1997)
Published	27 years, 8 months ago (Dec. 1, 1997)
Published Online	27 years, 8 months ago (Dec. 1, 1997)
Published Print	27 years, 8 months ago (Dec. 1, 1997)

Funders 0

None

BibTeX

@article{Hubbard_1997, title={sel-10, a negative regulator of lin-12 activity inCaenorhabditis elegans, encodes a member of the CDC4 family of proteins}, volume={11}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.11.23.3182}, DOI={10.1101/gad.11.23.3182}, number={23}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Hubbard, E. Jane Albert and Wu, Guangyu and Kitajewski, Jan and Greenwald, Iva}, year={1997}, month=dec, pages={3182–3193} }

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