Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure.
10.1101/gad.11.13.1717
Crossref journal-article
Cold Spring Harbor Laboratory
Genes & Development (246)
Abstract

During Drosophila embryogenesis, ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally. This process, dorsal closure, requires two signaling pathways: the Drosophila Jun-amino-terminal kinase (DJNK) pathway and the Dpp pathway. We have identified mutations in DJun and show that DJNK controls dorsal closure by activating DJun and inactivating the ETS repressor Aop/Yan by phosphorylation. DJun and Aop regulate dpp expression in the most dorsal row of cells. Secreted Dpp then instructs more ventrally located cells to stretch. Our results provide a causal link between the DJNK and Dpp pathways during dorsal closure. Interestingly, in vertebrates, transforming growth factor-beta and c-Jun regulate collagenase gene expression during wound healing, a process that also involves the closing of an epithelial sheath.

Bibliography

Riesgo-Escovar, J. R., & Hafen, E. (1997). Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure. Genes & Development, 11(13), 1717–1727.

Authors 2
  1. J R Riesgo-Escovar (first)
  2. E Hafen (additional)
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Dates
Type When
Created 18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited 3 years, 9 months ago (Nov. 14, 2021, 10:04 p.m.)
Indexed 1 week ago (Aug. 27, 2025, 11:36 a.m.)
Issued 28 years, 2 months ago (July 1, 1997)
Published 28 years, 2 months ago (July 1, 1997)
Published Online 28 years, 2 months ago (July 1, 1997)
Published Print 28 years, 2 months ago (July 1, 1997)
Funders 0

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@article{Riesgo_Escovar_1997, title={Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure.}, volume={11}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.11.13.1717}, DOI={10.1101/gad.11.13.1717}, number={13}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Riesgo-Escovar, J R and Hafen, E}, year={1997}, month=jul, pages={1717–1727} }