DOI: 10.1101/gad.11.10.1289. roughex down-regulates G2 cyclins in G1.

roughex down-regulates G2 cyclins in G1.

10.1101/gad.11.10.1289

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

Cell cycle arrest in G1 at the onset of patterning in the Drosophila eye is mediated by roughex. In roughex mutants, cells accumulate Cyclin A protein in early G1 and progress into S phase precociously. When Roughex is overexpressed in S/G2 cells, Cyclin A is mislocalized to the nucleus and degraded, preventing mitosis. Whereas Roughex inhibits Cyclin A accumulation, Cyclin E down-regulates Roughex protein in vivo. Roughex binds to Cyclin E and is a substrate for a Cyclin E-Cdk complex in vitro. These data argue that Roughex inhibits Cyclin A accumulation in early G1 by targeting Cyclin A for destruction. In late G1, Roughex is destabilized in a Cyclin E-dependent process, releasing Cyclin A for its role in S/G2.

Bibliography

Thomas, B. J., Zavitz, K. H., Dong, X., Lane, M. E., Weigmann, K., Finley, R. L., Brent, R., Lehner, C. F., & Zipursky, S. L. (1997). roughex down-regulates G2 cyclins in G1. Genes & Development, 11(10), 1289â1298.

Authors 9

B J Thomas (first)
K H Zavitz (additional)
X Dong (additional)
M E Lane (additional)
K Weigmann (additional)
R L Finley (additional)
R Brent (additional)
C F Lehner (additional)
S L Zipursky (additional)

References 49 Referenced 69

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{'key': '2021111418445172000_11.10.1289.36', 'first-page': '1669', 'article-title': 'Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system.', 'volume': '14', 'year': '1994', 'journal-title': 'Mol. Cell. Biol.'} / Mol. Cell. Biol. / Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. (1994)
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Dates

Type	When
Created	18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited	3 years, 9 months ago (Nov. 14, 2021, 10:02 p.m.)
Indexed	3 months, 3 weeks ago (May 8, 2025, 4:44 a.m.)
Issued	28 years, 3 months ago (May 15, 1997)
Published	28 years, 3 months ago (May 15, 1997)
Published Online	28 years, 3 months ago (May 15, 1997)
Published Print	28 years, 3 months ago (May 15, 1997)

Funders 0

None

BibTeX

@article{Thomas_1997, title={roughex down-regulates G2 cyclins in G1.}, volume={11}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.11.10.1289}, DOI={10.1101/gad.11.10.1289}, number={10}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Thomas, B J and Zavitz, K H and Dong, X and Lane, M E and Weigmann, K and Finley, R L and Brent, R and Lehner, C F and Zipursky, S L}, year={1997}, month=may, pages={1289–1298} }

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    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1997,
        5,
        15
      ]
    ]
  },
  "references-count": 49,
  "journal-issue": {
    "issue": "10",
    "published-print": {
      "date-parts": [
        [
          1997,
          5,
          15
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1101/gad.11.10.1289"
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  "URL": "http://dx.doi.org/10.1101/gad.11.10.1289",
  "relation": {},
  "ISSN": [
    "0890-9369",
    "1549-5477"
  ],
  "subject": [],
  "container-title-short": "Genes Dev.",
  "published": {
    "date-parts": [
      [
        1997,
        5,
        15
      ]
    ]
  }
}