DOI: 10.1101/gad.1014902. Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes

Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes

10.1101/gad.1014902

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

We describe distinct patterns of histone methylation during human cell cycle progression. Histone H4 methyltransferase activity was found to be cell cycle-regulated, consistent with increased H4 Lys 20 methylation at mitosis. This increase closely followed the cell cycle-regulated expression of the H4 Lys 20 methyltransferase, PR-Set7. Localization of PR-Set7 to mitotic chromosomes and subsequent increase in H4 Lys 20 methylation were inversely correlated to transient H4 Lys 16 acetylation in early S-phase. These data suggest that H4 Lys 20 methylation by PR-Set7 during mitosis acts to antagonize H4 Lys 16 acetylation and to establish a mechanism by which this mark is epigenetically transmitted.

Bibliography

Rice, J. C., Nishioka, K., Sarma, K., Steward, R., Reinberg, D., & Allis, C. D. (2002). Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Genes & Development, 16(17), 2225â2230.

Authors 6

Judd C. Rice (first)
Kenichi Nishioka (additional)
Kavitha Sarma (additional)
Ruth Steward (additional)
Danny Reinberg (additional)
C. David Allis (additional)

References 29 Referenced 198

Dates

Type	When
Created	22 years, 11 months ago (Sept. 3, 2002, 12:44 p.m.)
Deposited	3 years, 9 months ago (Nov. 15, 2021, 11:13 a.m.)
Indexed	1 month, 3 weeks ago (July 2, 2025, 1:51 p.m.)
Issued	22 years, 11 months ago (Sept. 1, 2002)
Published	22 years, 11 months ago (Sept. 1, 2002)
Published Online	22 years, 11 months ago (Sept. 1, 2002)
Published Print	22 years, 11 months ago (Sept. 1, 2002)

Funders 0

None

BibTeX

@article{Rice_2002, title={Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes}, volume={16}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.1014902}, DOI={10.1101/gad.1014902}, number={17}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Rice, Judd C. and Nishioka, Kenichi and Sarma, Kavitha and Steward, Ruth and Reinberg, Danny and Allis, C. David}, year={2002}, month=sep, pages={2225–2230} }

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