DOI: 10.1101/gad.10.3.301. Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

10.1101/gad.10.3.301

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

The signaling protein Hedgehog (Hh) controls cell fate and polarizes tissues in both flies and vertebrates. In flies, Hh exerts its effects by opposing the function of a novel transmembrane protein, Patched, while also locally inducing patched (ptc) transcription. We have identified a mouse homolog of ptc which in many tissues is transcribed near cells making either Sonic or Indian hedgehog. In addition, ectopic Sonic hedgehog expression in the mouse central nervous system induces ptc transcription. As in flies, mouse ptc transcription appears to be indicative of hedgehog signal reception. The results support the existence of a conserved signaling pathway used for pattern formation in insects and mammals.

Bibliography

Goodrich, L. V., Johnson, R. L., Milenkovic, L., McMahon, J. A., & Scott, M. P. (1996). Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes & Development, 10(3), 301â312.

Authors 5

L V Goodrich (first)
R L Johnson (additional)
L Milenkovic (additional)
J A McMahon (additional)
M P Scott (additional)

References 63 Referenced 702

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Dates

Type	When
Created	18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited	3 years, 9 months ago (Nov. 14, 2021, 9:47 p.m.)
Indexed	3 weeks ago (Aug. 5, 2025, 8:37 a.m.)
Issued	29 years, 6 months ago (Feb. 1, 1996)
Published	29 years, 6 months ago (Feb. 1, 1996)
Published Online	29 years, 6 months ago (Feb. 1, 1996)
Published Print	29 years, 6 months ago (Feb. 1, 1996)

Funders 0

None

BibTeX

@article{Goodrich_1996, title={Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.}, volume={10}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.10.3.301}, DOI={10.1101/gad.10.3.301}, number={3}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Goodrich, L V and Johnson, R L and Milenkovic, L and McMahon, J A and Scott, M P}, year={1996}, month=feb, pages={301–312} }

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