DOI: 10.1101/gad.1.9.981. Complementary patterns of even-skipped and fushi tarazu expression involve their differential regulation by a common set of segmentation genes in Drosophila.

Complementary patterns of even-skipped and fushi tarazu expression involve their differential regulation by a common set of segmentation genes in Drosophila.

10.1101/gad.1.9.981

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

We have examined the position-dependent expression of two segmentation genes that contain a homeo box, even-skipped (eve) and fushi tarazu (ftz). Products encoded by both genes accumulate in a series of seven transverse stripes along the anterior-posterior body axis of developing embryos. Double-staining experiments show that eve and ftz proteins accumulate in complementary sets of embryonic cells. A total of eight zygotically active segmentation genes are required for the establishment and refinement of the eve and ftz expression patterns during development. Mutations that affect one of the genes were always found to produce a reciprocal alteration in the other. These results suggest that the eve and ftz promoters independently "interpret" the same positional cues to give differential patterns of expression. We propose that a combination of segmentation gene products that activates the expression of eve represses the expression of ftz, and vice versa. This proposal is discussed in the context of a hierarchy of interactions among segmentation genes, whereby the gap genes establish asymmetric patterns of eve and ftz expression in blastoderm-stage embryos, and interactions with other pair-rule genes serve to refine further the complementarity of eve and ftz expression during gastrulation and germ band elongation.

Bibliography

Frasch, M., & Levine, M. (1987). Complementary patterns of even-skipped and fushi tarazu expression involve their differential regulation by a common set of segmentation genes in Drosophila. Genes & Development, 1(9), 981â995.

Authors 2

M Frasch (first)
M Levine (additional)

References 34 Referenced 205

10.1016/0092-8674(85)90011-X
10.1016/0092-8674(86)90543-X
10.1002/j.1460-2075.1987.tb04817.x / EMBO J. / Characterization and localization of the even-skipped protein of Drosophila. (1987)
10.1038/324120a0
10.1016/0092-8674(86)90393-4
{'key': '2021111319434943000_1.9.981.6', 'first-page': '38', 'article-title': 'Schadigungsmuster eines Letalfaktors (Kr) von Drosophila melanogaster.', 'volume': '25', 'year': '1950', 'journal-title': 'Arch. Jul. Klaus Stiftung'} / Arch. Jul. Klaus Stiftung / Schadigungsmuster eines Letalfaktors (Kr) von Drosophila melanogaster. (1950)
10.1016/0092-8674(84)90417-3
10.1126/science.3755551
10.1016/0092-8674(86)90018-8
10.1002/j.1460-2075.1986.tb04409.x / EMBO J. / Corre-lative changes in homeotic and segmentation gene expression in Krüppel mutant embryos of Drosophila. (1986)
10.1038/324592a0
10.1038/324668a0
10.1007/BF00848157
10.1038/317040a0
10.1038/310025a0
Lehmann, R. 1985. “Regionsspezifische Segmentierungsmutanten bei Drosophila melanogaster meigen.” Ph.D. dissertation, Eberhard-Karls-Universitat, Tübingen, Germany.
10.1016/0012-1606(87)90045-5
10.1016/0092-8674(86)90515-5
10.1016/0012-1606(87)90310-1
10.1038/313639a0
10.1038/308428a0
10.1016/0092-8674(84)90370-2
{'issue': '(Suppl.)', 'key': '2021111319434943000_1.9.981.23', 'first-page': '357', 'article-title': 'Hierarchical inductions of cell states: A model for segmentation in Drosophila.', 'volume': '4', 'year': '1986', 'journal-title': 'J. Cell Sci.'} / J. Cell Sci. / Hierarchical inductions of cell states: A model for segmentation in Drosophila. (1986)
Nüsslein-Volhard, C. 1979. Maternal effect mutations that alter the spatial coordinates of the embryo of Drosophila melanogaster. In Determinants of spatial organization (ed. S. Subtelny, and I.R. Koenigsberg), pp. 185–211. Academic Press, New York. (10.1016/B978-0-12-612983-0.50016-X)
10.1038/287795a0
10.1007/BF00848156
10.1101/SQB.1985.050.01.020 / Cold Spring Harb. Symp. Quant. Biol. / Genes affecting the segmental subdivision of the Drosophila embryo. (1985)
10.1016/0012-1606(87)90219-3
10.1073/pnas.81.13.4115
10.1016/0012-1606(86)90108-9
10.1038/327383a0
10.1016/0012-1606(84)90182-9
10.1016/0012-1606(84)90046-0
10.1007/BF00848158

Dates

Type	When
Created	18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited	3 years, 9 months ago (Nov. 13, 2021, 10:46 p.m.)
Indexed	6 days, 12 hours ago (Aug. 20, 2025, 8:44 a.m.)
Issued	37 years, 9 months ago (Nov. 1, 1987)
Published	37 years, 9 months ago (Nov. 1, 1987)
Published Online	37 years, 9 months ago (Nov. 1, 1987)
Published Print	37 years, 9 months ago (Nov. 1, 1987)

Funders 0

None

BibTeX

@article{Frasch_1987, title={Complementary patterns of even-skipped and fushi tarazu expression involve their differential regulation by a common set of segmentation genes in Drosophila.}, volume={1}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.1.9.981}, DOI={10.1101/gad.1.9.981}, number={9}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Frasch, M and Levine, M}, year={1987}, month=nov, pages={981–995} }

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