DOI: 10.1101/gad.1.10.1132. Identification of factors that interact with the E1A-inducible adenovirus E3 promoter.

Identification of factors that interact with the E1A-inducible adenovirus E3 promoter.

10.1101/gad.1.10.1132

Crossref journal-article

Cold Spring Harbor Laboratory

Genes & Development (246)

Abstract

We have investigated the E1A-inducible E3 promoter of adenovirus type 5 with respect to its ability to bind specific nuclear proteins. Four distinct nucleoprotein-binding sites were detected, located between positions-7 to -33, -44 to -68, -81 to -103, and -154 to -183, relative to the E3 cap site. These sites contain sequences previously shown to be functionally important for efficient E3 transcription. No major qualitative or quantitative differences were found in the binding pattern between nucleoprotein extracts prepared from uninfected or adenovirus-infected HeLa cells. Competition experiments suggest that the factors binding to the -154 to -183 and -81 to -103 sites are the previously identified nucleoproteins, NF1 and AP1, respectively. The factor binding to the -44 to -68 site, which we term ATF, also interacts with other E1A-inducible promoters and is very similar and probably identical to the factor that binds to the cAMP-responsive element of somatostatin. We have purified this factor, which is a protein of 43 kD in size.

Bibliography

Hurst, H. C., & Jones, N. C. (1987). Identification of factors that interact with the E1A-inducible adenovirus E3 promoter. Genes & Development, 1(10), 1132â1146.

Authors 2

H C Hurst (first)
N C Jones (additional)

References 48 Referenced 119

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Dates

Type	When
Created	18 years, 2 months ago (June 5, 2007, 5:15 p.m.)
Deposited	3 years, 9 months ago (Nov. 13, 2021, 10:46 p.m.)
Indexed	1 year, 10 months ago (Oct. 23, 2023, 10:27 a.m.)
Issued	37 years, 9 months ago (Dec. 1, 1987)
Published	37 years, 9 months ago (Dec. 1, 1987)
Published Online	37 years, 9 months ago (Dec. 1, 1987)
Published Print	37 years, 9 months ago (Dec. 1, 1987)

Funders 0

None

BibTeX

@article{Hurst_1987, title={Identification of factors that interact with the E1A-inducible adenovirus E3 promoter.}, volume={1}, ISSN={1549-5477}, url={http://dx.doi.org/10.1101/gad.1.10.1132}, DOI={10.1101/gad.1.10.1132}, number={10}, journal={Genes & Development}, publisher={Cold Spring Harbor Laboratory}, author={Hurst, H C and Jones, N C}, year={1987}, month=dec, pages={1132–1146} }

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          1987,
          12
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1101/gad.1.10.1132"
  ],
  "URL": "http://dx.doi.org/10.1101/gad.1.10.1132",
  "relation": {},
  "ISSN": [
    "0890-9369",
    "1549-5477"
  ],
  "subject": [],
  "container-title-short": "Genes Dev.",
  "published": {
    "date-parts": [
      [
        1987,
        12
      ]
    ]
  }
}