DOI: 10.1098/rstb.1999.0394. Processing of ARIA and release from isolated nerve terminals

Processing of ARIA and release from isolated nerve terminals

10.1098/rstb.1999.0394

Crossref journal-article

The Royal Society

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences (175)

Abstract

The neuromuscular junction is a specialized synapse in that every action potential in the presynaptic nerve terminal results in an action potential in the postsynaptic membrane, unlike most interneuronal synapses where a single presynaptic input makes only a small contribution to the population postsynaptic response. The postsynaptic membrane at the neuromuscular junction contains a high density of neurotransmitter (acetylcholine) receptors and a high density of voltage–gated Na+channels. Thus, the large acetylcholine activated current occurs at the same site where the threshold for action potential generation is low. Acetylcholine receptor inducing activity (ARIA), a 42 kD protein, that stimulates synthesis of acetylcholine receptors and voltage–gated Na+channels in cultured myotubes, probably plays the same roles at developing and mature motor endplatesin vivo. ARIA is synthesized as part of a larger, transmembrane, precursor protein called proARIA. Delivery of ARIA from motor neuron cell bodies in the spinal cord to the target endplates involves several steps, including proteolytic cleavage of proARIA. ARIA is also expressed in the central nervous system and it is abundant in the molecular layer of the cerebellum. In this paper we describe our first experiments on the processing and release of ARIA from subcellular fractions containing synaptosomes from the chick cerebellum as a model system.

Bibliography

Han, B., & Fischbach, G. D. (1999). Processing of ARIA and release from isolated nerve terminals. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 354(1381), 411â416.

Authors 2

Bomie Han (first)
Gerald D. Fischbach (additional)

References 39 Referenced 14

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 7:55 p.m.)
Deposited	4 years, 3 months ago (May 17, 2021, 6:36 p.m.)
Indexed	11 months, 4 weeks ago (Sept. 6, 2024, 3:05 a.m.)
Issued	26 years, 6 months ago (Feb. 28, 1999)
Published	26 years, 6 months ago (Feb. 28, 1999)
Published Online	26 years, 6 months ago (Feb. 28, 1999)
Published Print	26 years, 6 months ago (Feb. 28, 1999)

Funders 0

None

BibTeX

@article{Han_1999, title={Processing of ARIA and release from isolated nerve terminals}, volume={354}, ISSN={1471-2970}, url={http://dx.doi.org/10.1098/rstb.1999.0394}, DOI={10.1098/rstb.1999.0394}, number={1381}, journal={Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences}, publisher={The Royal Society}, author={Han, Bomie and Fischbach, Gerald D.}, editor={Clementi, F. and Fesce, R. and Meldolesi, J. and Valtorta, F.}, year={1999}, month=feb, pages={411–416} }

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