Epidermal stem cells: markers, patterning and the control of stem cell fate
10.1098/rstb.1998.0247
Crossref journal-article
The Royal Society
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences (175)
Abstract

Within the epidermis, proliferation takes place in the basal layer of keratinocytes that are attached to an underlying basement membrane. Cells that leave the basal layer undergo terminal differentiation as they move towards the tissue surface. The basal layer contains two types of proliferative keratinocyte: stem cells, which have unlimited self–renewal capacity, and transit amplifying cells, those daughters of stem cells that are destined to withdraw from the cell cycle and terminally differentiate after a few rounds of division. Stem cells express higher levels of the β1–integrin family of extracellular matrix receptors than transit amplifying cells and this can be used to isolate each subpopulation of keratinocyte and to determine its location within the epidermis. Variation in the levels of E–cadherin, β–catenin and plakoglobin within the basal layer suggests that stem cells may also differ from transit amplifying cells in intercellular adhesiveness. Stem cells have a patterned distribution within the epidermal basal layer and patterning is subject to autoregulation. Constitutive expression of the transcription factor c–Myc promotes terminal differentiation by driving keratinocytes from the stem cell compartment into the transit amplifying compartment.

Bibliography

Watt, F. M. (1998). Epidermal stem cells: markers, patterning and the control of stem cell fate. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 353(1370), 831–837.

Authors 1
  1. Fiona M. Watt (first)
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Dates
Type When
Created 23 years ago (July 26, 2002, 7:55 p.m.)
Deposited 4 years, 3 months ago (May 17, 2021, 6:32 p.m.)
Indexed 1 month ago (July 22, 2025, 6:57 a.m.)
Issued 27 years, 1 month ago (June 29, 1998)
Published 27 years, 1 month ago (June 29, 1998)
Published Online 27 years, 1 month ago (June 29, 1998)
Published Print 27 years, 1 month ago (June 29, 1998)
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@article{Watt_1998, title={Epidermal stem cells: markers, patterning and the control of stem cell fate}, volume={353}, ISSN={1471-2970}, url={http://dx.doi.org/10.1098/rstb.1998.0247}, DOI={10.1098/rstb.1998.0247}, number={1370}, journal={Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences}, publisher={The Royal Society}, author={Watt, Fiona M.}, editor={Crompton, M. J. and Dexter, T. M. and Wright, N. A.}, year={1998}, month=jun, pages={831–837} }