DOI: 10.1098/rstb.1995.0117. Evolution of a dynamic cytoskeleton

10.1098/rstb.1995.0117

Crossref journal-article

The Royal Society

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences (175)

Abstract

Actin filaments and microtubules form the cytoskeleton of all eukaryotic cells, and they are responsible for organizing the cytoplasm and supporting motile processes. Both polymers are highly dynamic, and their polymerization dynamics are central to their organization. Though their evolutionary origins appear to be distinct, actin and tubulin have a similar mechanism for promoting polymerization dynamics in which the energy of nucleotide triphosphate hydrolysis during polymerization is used to weaken the bonds between subunits, thus promoting subsequent depolymerization. The evolutionary origins of actin and tubulin are unclear. It is likely that motile mechanisms driven by reversible polymerization, termed thermal ratchets, are older than those based on ATPase motor proteins. Such mechanisms are still important in modern eukaryotes, and may have powered early versions of the critical motile processes of phagocytosis and chromosome segregation in primitive cells. Thus evolution of dynamic cytoskeletal polymers may have been one of the earliest and most important steps leading to the evolution of eukaryotes. Plausible evolutionary pathways can be constructed leading from simple enzymes to dynamic cytoskeletal polymers.

Bibliography

Evolution of a dynamic cytoskeleton. (1995). Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 349(1329), 299â304.

Authors 0

None

References 18 Referenced 47

10.1128/MR.58.3.387-400.1994 / Microbiol. Rev. / Do prokaryotes contain microtubules by Bermudes D. (1994)
10.1083/jcb.127.3.779
10.1016/0955-0674(94)90120-1
10.1083/jcb.128.1.1
10.1016/0092-8674(95)90486-7
10.1016/0955-0674(92)90065-K
10.1016/0955-0674(94)90126-0
10.1073/pnas.88.11.5041
10.1016/S0074-7696(08)60235-1
10.1073/pnas.82.13.4404
10.1016/S0959-437X(05)80100-5
10.1016/0092-8674(86)90318-1
10.1016/0014-5793(94)00552-4
10.1091/mbc.3.12.1309
10.1016/S0006-3495(93)81035-X
10.1016/0955-0674(95)80039-5
Stryer L. 1981 Biochemistry (2nd edn.) pp. 87-102. New York: Freeman.
10.1016/0012-1606(88)90279-5

Dates

Type	When
Created	18 years, 8 months ago (Dec. 15, 2006, 5:45 p.m.)
Deposited	4 years, 6 months ago (Feb. 15, 2021, 2:06 a.m.)
Indexed	1 month, 2 weeks ago (July 9, 2025, 6:50 p.m.)
Issued	29 years, 10 months ago (Sept. 29, 1995)
Published	29 years, 10 months ago (Sept. 29, 1995)
Published Online	28 years, 7 months ago (Jan. 1, 1997)
Published Print	29 years, 10 months ago (Sept. 29, 1995)

Funders 0

None

BibTeX

@article{1995, volume={349}, ISSN={1471-2970}, url={http://dx.doi.org/10.1098/rstb.1995.0117}, DOI={10.1098/rstb.1995.0117}, number={1329}, journal={Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences}, publisher={The Royal Society}, year={1995}, month=sep, pages={299–304} }

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