DOI: 10.1097/00004647-199601000-00013. Short Therapeutic Window for MK-801 in Transient Focal Cerebral Ischemia in Normotensive Rats

Short Therapeutic Window for MK-801 in Transient Focal Cerebral Ischemia in Normotensive Rats

10.1097/00004647-199601000-00013

Crossref journal-article

SAGE Publications

Journal of Cerebral Blood Flow & Metabolism (179)

Abstract

The present study investigates the role of N-methyl-D-aspartate (NMDA) receptors in a model of transient focal cerebral ischemia in normotensive rats. The left middle cerebral artery and both common carotid arteries were occluded for 60 min. Preliminary studies indicated that this gave reproducible infarctions of the cortex and striatum. These infarctions were the result of severe ischemia followed by complete reperfusion after clamp removal, as showed by striatal tissue Po2 monitoring. Microdialysis indicated that glutamate concentration increased immediately after occlusion and returned to the baseline value 40 min after clamp removal. MK-801 (1 mg kg−1 i.v.), an antagonist of the NMDA glutamatergic receptor, reduced the cortical infarct volume by 29% (p < 0.001) and the striatal infarct volume by 14% (p < 0.05) when given just prior to ischemia, but had no neuroprotective activity when given 30 min after the onset of ischemia. This short therapeutic window for MK-801 suggests that NMDA receptors play only a transient role in reversible focal ischemia in rats.

Bibliography

Margaill, I., Parmentier, S., Callebert, J., Allix, M., Boulu, R. G., & Plotkine, M. (1996). Short Therapeutic Window for MK-801 in Transient Focal Cerebral Ischemia in Normotensive Rats. Journal of Cerebral Blood Flow & Metabolism, 16(1), 107â113.

Authors 6

I. Margaill (first)
S. Parmentier (additional)
J. Callebert (additional)
M. Allix (additional)
R. G. Boulu (additional)
M. Plotkine (additional)

References 32 Referenced 74

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10.1111/j.1471-4159.1993.tb02174.x
10.1161/01.STR.21.12.1727
10.1016/0022-510X(76)90231-8
10.1111/j.1476-5381.1994.tb16201.x
10.1016/0022-510X(94)90164-3
10.1161/01.STR.24.12.2087
10.1038/jcbfm.1995.19
10.1227/00006123-199306000-00017
10.1016/0014-2999(92)90201-E
{'key': 'bibr11-00004647-199601000-00013', 'first-page': 'H252', 'volume': '265', 'author': 'He YY', 'year': '1993', 'journal-title': 'Am J Physiol'} / Am J Physiol by He YY (1993)
10.1038/jcbfm.1989.87
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10.1111/j.1365-2125.1992.tb05634.x
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{'key': 'bibr20-00004647-199601000-00013', 'first-page': '377', 'volume-title': 'Stroke, Vol 1: Pathophysiology, Diagnosis and Management', 'author': 'Mohr JP', 'year': '1986'} / Stroke, Vol 1: Pathophysiology, Diagnosis and Management by Mohr JP (1986)
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{'key': 'bibr24-00004647-199601000-00013', 'volume-title': 'The Rat Brain Stereotaxic Coordinates.', 'author': 'Paxinos G', 'year': '1986', 'edition': '2'} / The Rat Brain Stereotaxic Coordinates. by Paxinos G (1986)
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{'key': 'bibr26-00004647-199601000-00013', 'first-page': 'H1770', 'volume': '266', 'author': 'Takagi K', 'year': '1994', 'journal-title': 'Am J Physiol'} / Am J Physiol by Takagi K (1994)
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10.1227/00006123-199402000-00018
10.1212/WNL.41.6.899

Dates

Type	When
Created	21 years, 9 months ago (Nov. 18, 2003, 9 a.m.)
Deposited	5 months, 1 week ago (March 10, 2025, 12:04 p.m.)
Indexed	1 day, 23 hours ago (Aug. 21, 2025, 1:40 p.m.)
Issued	29 years, 7 months ago (Jan. 1, 1996)
Published	29 years, 7 months ago (Jan. 1, 1996)
Published Online	29 years, 7 months ago (Jan. 1, 1996)
Published Print	29 years, 7 months ago (Jan. 1, 1996)

Funders 0

None

BibTeX

@article{Margaill_1996, title={Short Therapeutic Window for MK-801 in Transient Focal Cerebral Ischemia in Normotensive Rats}, volume={16}, ISSN={1559-7016}, url={http://dx.doi.org/10.1097/00004647-199601000-00013}, DOI={10.1097/00004647-199601000-00013}, number={1}, journal={Journal of Cerebral Blood Flow & Metabolism}, publisher={SAGE Publications}, author={Margaill, I. and Parmentier, S. and Callebert, J. and Allix, M. and Boulu, R. G. and Plotkine, M.}, year={1996}, month=jan, pages={107–113} }

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