DOI: 10.1096/fj.04-3515com. Brain mitochondria contain aquaporin water channels: evidence for the expression of a short AQP9 isoform in the inner mitochondrial membrane

Brain mitochondria contain aquaporin water channels: evidence for the expression of a short AQP9 isoform in the inner mitochondrial membrane

10.1096/fj.04-3515com

Crossref journal-article

Wiley

The FASEB Journal (311)

Abstract

ABSTRACTAquaporins are a family of water channels found in animals, plants, and microorganisms. A subfamily of aquaporins, the aquaglyceroporins, are permeable for water as well as certain solutes such as glycerol, lactate, and urea. Here we show that the brain contains two isoforms of AQP9—an aquaglyceroporin with a particularly broad substrate specificity—and that the more prevalent of these isoforms is expressed in brain mitochondria. The mitochondrial AQP9 isoform is detected as an ∼25 kDa band in immunoblots. This isoform is likely to correspond to a new AQP9 mRNA that is obtained by alternative splicing and has a shorter ORF than the liver isoform. Subfractionation experiments and high‐resolution immunogold analyses revealed that this novel AQP9 isoform is enriched in mitochondrial inner membranes. AQP9 immunopositive mitochondria occurred in astrocytes throughout the brain and in a subpopulation of neurons in the substantia nigra, ventral tegmental area, and arcuate nucleus. In the latter structures, the AQP9 immunopositive mitochondria were located in neurons that were also immunopositive for tyrosine hydroxylase, as demonstrated by double labeling immunogold electron microscopy. Our findings suggest that mitochondrial AQP9 is a hallmark of astrocytes and midbrain dopaminergic neurons. In physiological conditions, the flux of lactate and other metabolites through AQP9 may confer an advantage by allowing the mitochondria to adjust to the metabolic status of the extramitochondrial cytoplasm. We hypothesize that the complement of mitochondrial AQP9 in dopaminergic neurons may relate to the vulnerability of these neurons in Parkinson's disease. Amiry‐Moghaddam, M., Lindland, H., Zelenin, S., Roberg, B. A., Gundersen, B. B., Petersen, P., Rinvik, R., Torgner, I. A., Ottersen, O. P. Brain mitochondria contain aquaporin water channels: evidence for the expression of a short AQP9 isoform in the inner mitochondrial membrane. FASEB J. 19, 1459–1467 (2005)

Bibliography

AmiryâMoghaddam, M., Lindland, H., Zelenin, S., Roberg, B. Ã., Gundersen, B. B., Petersen, P., Rinvik, E., Torgner, I. A., & Ottersen, O. P. (2005). Brain mitochondria contain aquaporin water channels: evidence for the expression of a short AQP9 isoform in the inner mitochondrial membrane. The FASEB Journal, 19(11), 1459â1467. Portico.

Authors 9

Mahmood Amiry‐Moghaddam (first)
Heidi Lindland (additional)
Sergey Zelenin (additional)
Bjørg Å. Roberg (additional)
Brigitta B. Gundersen (additional)
Petur Petersen (additional)
Eric Rinvik (additional)
Ingeborg A. Torgner (additional)
Ole P. Ottersen (additional)

References 47 Referenced 111

10.1113/jphysiol.2002.020818
10.1038/nrn1252
10.1073/pnas.90.15.7275
10.1007/978-3-7091-0651-8_107
10.1016/j.neuroscience.2004.05.042
10.1006/bbrc.2000.3505
10.1074/jbc.273.38.24737
10.1097/00004647-200105000-00001
10.1177/002215540104901208
10.1016/S0021-9258(17)32653-4
10.1128/jb.172.1.424-430.1990
10.1152/ajprenal.1999.277.5.F685
10.1007/s002390010169
10.1016/S0022-5193(87)80123-6
10.1152/ajpcell.2000.279.3.C648
10.1023/A:1020985600422
10.1016/0197-0186(95)00018-4
10.1074/jbc.M304940200
10.1073/pnas.0437946100
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{'key': 'e_1_2_6_38_1', 'first-page': '131', 'article-title': 'Lactate, glucose and energy metabolism in the ischemic brain (review)', 'volume': '10', 'author': 'Schurr A.', 'year': '2002', 'journal-title': 'Int. J. Mol. Med.'} / Int. J. Mol. Med. / Lactate, glucose and energy metabolism in the ischemic brain (review) by Schurr A. (2002)
10.1023/B:JOBB.0000041761.61554.44
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{'key': 'e_1_2_6_45_1', 'first-page': '239', 'article-title': "Occupational exposure to manganese, copper, lead, iron, mercury and zinc and the risk of Parkinson's disease", 'volume': '20', 'author': 'Gorell J. M.', 'year': '1999', 'journal-title': 'Neurotoxicology'} / Neurotoxicology / Occupational exposure to manganese, copper, lead, iron, mercury and zinc and the risk of Parkinson's disease by Gorell J. M. (1999)
10.1006/exnr.1998.6854
10.1016/S0306-4522(98)00298-X
10.1523/JNEUROSCI.17-01-00171.1997

Dates

Type	When
Created	20 years ago (Aug. 26, 2005, 3:28 p.m.)
Deposited	1 year, 2 months ago (June 11, 2024, 12:43 a.m.)
Indexed	1 week, 3 days ago (Aug. 23, 2025, 9:52 p.m.)
Issued	20 years ago (Sept. 1, 2005)
Published	20 years ago (Sept. 1, 2005)
Published Online	20 years ago (Sept. 1, 2005)
Published Print	20 years ago (Sept. 1, 2005)

Funders 3

Norges Forskningsråd 10.13039/501100005416
Region: Europe
gov (National government)
Labels3
1. Forskningsrådet
2. Norwegian Research Council
3. Research Council of Norway
Nordisk Ministerråd 10.13039/501100004182
Region: Europe
gov (National government)
Labels2
1. Nordic Council of Ministers
2. NMR
European Molecular Biology Organization 10.13039/100004410
Region: Europe
pri (International organizations)
Labels2
1. The European Molecular Biology Organization
2. EMBO

BibTeX

@article{Amiry_Moghaddam_2005, title={Brain mitochondria contain aquaporin water channels: evidence for the expression of a short AQP9 isoform in the inner mitochondrial membrane}, volume={19}, ISSN={1530-6860}, url={http://dx.doi.org/10.1096/fj.04-3515com}, DOI={10.1096/fj.04-3515com}, number={11}, journal={The FASEB Journal}, publisher={Wiley}, author={Amiry‐Moghaddam, Mahmood and Lindland, Heidi and Zelenin, Sergey and Roberg, Bjørg Å. and Gundersen, Brigitta B. and Petersen, Petur and Rinvik, Eric and Torgner, Ingeborg A. and Ottersen, Ole P.}, year={2005}, month=sep, pages={1459–1467} }

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