Crossref journal-article
Oxford University Press (OUP)
Nucleic Acids Research (286)
Bibliography

Galganski, L., Urbanek, M. O., & Krzyzosiak, W. J. (2017). Nuclear speckles: molecular organization, biological function and role in disease. Nucleic Acids Research, 45(18), 10350–10368.

Authors 3
  1. Lukasz Galganski (first)
  2. Martyna O. Urbanek (additional)
  3. Wlodzimierz J. Krzyzosiak (additional)
References 215 Referenced 420
  1. {'key': 'key\n\t\t\t\t20171219124455_B1', 'first-page': 'a000711', 'article-title': 'Biogenesis of nuclear bodies', 'volume': '2', 'year': '2010', 'journal-title': 'Cold Spring Harb. Perspect. Biol.'} / Cold Spring Harb. Perspect. Biol. / Biogenesis of nuclear bodies (2010)
  2. 10.1016/j.tig.2011.05.006 / Trends Genet. / Biogenesis and function of nuclear bodies (2011)
  3. 10.1016/j.ceb.2012.03.010 / Curr. Opin. Cell Biol. / Nuclear bodies: multifunctional companions of the genome (2012)
  4. {'key': 'key\n\t\t\t\t20171219124455_B4', 'first-page': 'a000646', 'article-title': 'Nuclear speckles', 'volume': '3', 'year': '2011', 'journal-title': 'Cold Spring Harb. Perspect. Biol.'} / Cold Spring Harb. Perspect. Biol. / Nuclear speckles (2011)
  5. 10.1002/path.4426 / J. Pathol. / PML nuclear bodies: regulation, function and therapeutic perspectives (2014)
  6. 10.1016/j.ceb.2014.03.004 / Curr. Opin. Cell Biol. / Nuclear bodies: new insights into assembly/dynamics and disease relevance (2014)
  7. {'key': 'key\n\t\t\t\t20171219124455_B7', 'first-page': '1', 'article-title': 'Immunoelectron microscopic localization of snRNPs', 'volume': '49', 'year': '1983', 'journal-title': 'Biol. Cell'} / Biol. Cell / Immunoelectron microscopic localization of snRNPs (1983)
  8. {'key': 'key\n\t\t\t\t20171219124455_B8', 'first-page': '635', 'article-title': 'Intranuclear struc- tures recognized by autoantibodies against ribonucleo- proteins: Study on monkey kidney cells in culture using immunofluorescent techniques and immunoelectron microscopy', 'volume': '130', 'year': '1979', 'journal-title': 'Ann. Immunol.'} / Ann. Immunol. / Intranuclear struc- tures recognized by autoantibodies against ribonucleo- proteins: Study on monkey kidney cells in culture using immunofluorescent techniques and immunoelectron microscopy (1979)
  9. 10.1002/j.1460-2075.1991.tb04911.x / EMBO J. / Associations between distinct pre-mRNA splicing components and the cell nucleus (1991)
  10. 10.1177/002215549804600313 / J. Histochem. Cytochem. / Fine structural specific visualization of RNA on ultrathin sections (1998)
  11. 10.1038/ncomms1998 / Nat. Commun. / Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion (2012)
  12. 10.1038/ncomms1103 / Nat. Commun. / A role for TREX components in the release of spliced mRNA from nuclear speckle domains (2010)
  13. {'key': 'key\n\t\t\t\t20171219124455_B13', 'first-page': '1203', 'article-title': 'Variations in the morphological patterns of ‘autoimmune’ nuclear fluorescence', 'volume': '1', 'year': '1961', 'journal-title': 'Lancet'} / Lancet / Variations in the morphological patterns of ‘autoimmune’ nuclear fluorescence (1961)
  14. 10.1016/S0022-5320(69)80017-1 / J. Ultrastruct. Res. / Fine structural organization of the interphase nucleus in some mammalian cells (1969)
  15. 10.1002/jcp.25224 / J. Cell. Physiol. / Coordinated dynamics of RNA splicing speckles in the nucleus (2016)
  16. 10.1016/j.cell.2007.01.028 / Cell / Beyond the sequence: cellular organization of genome function (2007)
  17. 10.1016/0014-4827(78)90230-6 / Exp. Cell Res. / The reversible action of alpha-amanitin on nuclear structure and molecular composition (1978)
  18. 10.7150/thno.11863 / Theranostics / Single cell assay for molecular diagnostics and medicine: monitoring Intracellular concentrations of macromolecules by two-photon fluorescence lifetime imaging (2015)
  19. 10.1016/j.bpj.2010.06.069 / Biophys. J. / Nonlinear optical imaging and raman microspectrometry of the cell nucleus throughout the cell cycle (2010)
  20. 10.1038/35007077 / Nature / High mobility of proteins in the mammalian cell nucleus (2000)
  21. 10.1093/emboj/18.15.4308 / EMBO J. / Purification and biochemical characterization of interchromatin granule clusters (1999)
  22. 10.1091/mbc.E04-03-0253 / Mol. Biol. Cell / Proteomic analysis of interchromatin granule clusters (2004)
  23. 10.15252/embj.201593169 / EMBO J. / Higher-order oligomerization promotes localization of SPOP to liquid nuclear speckles (2016)
  24. 10.1038/nature10879 / Nature / Phase transitions in the assembly of multivalent signalling proteins (2012)
  25. 10.1016/j.molcel.2015.01.013 / Mol. Cell / Phase transition of a disordered nuage protein generates environmentally responsive membraneless organelles (2015)
  26. 10.1073/pnas.0802533105 / Proc. Natl. Acad. Sci. U.S.A. / Akt phosphorylation and nuclear phosphoinositide association mediate mRNA export and cell proliferation activities by ALY (2008)
  27. 10.1074/jbc.M405006200 / J. Biol. Chem. / SUMO modification of repression domains modulates function of nuclear receptor 5A1 (steroidogenic factor-1) (2004)
  28. 10.1038/369678a0 / Nature / A serine kinase regulates intracellular localization of splicing factors in the cell cycle (1994)
  29. 10.1002/j.1460-2075.1996.tb00357.x / EMBO J. / The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution (1996)
  30. 10.1091/mbc.7.10.1559 / Mol. Biol. Cell / Serine/threonine phosphatase 1 modulates the subnuclear distribution of pre-mRNA splicing factors (1996)
  31. 10.1016/j.str.2013.09.014 / Structure / Phosphorylation drives a dynamic switch in serine/arginine-rich proteins (2013)
  32. 10.1371/journal.pgen.1000397 / PLoS Genet. / Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment (2009)
  33. 10.1242/jcs.00618 / J. Cell Sci. / DYRK1A accumulates in splicing speckles through a novel targeting signal and induces speckle disassembly (2003)
  34. 10.1083/jcb.126.1.11 / J. Cell Biol. / Differential interaction of splicing snRNPs with coiled bodies and interchromatin granules during mitosis and assembly of daughter cell nuclei (1994)
  35. {'key': 'key\n\t\t\t\t20171219124455_B35', 'first-page': '376', 'article-title': 'Ultrastructural distribution of ribonucleoprotein complexes during mitosis. snRNP antigens are contained in mitotic granule clusters', 'volume': '50', 'year': '1989', 'journal-title': 'Eur. J. Cell Biol.'} / Eur. J. Cell Biol. / Ultrastructural distribution of ribonucleoprotein complexes during mitosis. snRNP antigens are contained in mitotic granule clusters (1989)
  36. 10.1091/mbc.E02-10-0669 / Mol. Biol. Cell / Sequential entry of components of gene expression machinery into daughter nuclei (2003)
  37. 10.1083/jcb.200404120 / J. Cell Biol. / Hypophosphorylated SR splicing factors transiently localize around active nucleolar organizing regions in telophase daughter nuclei (2004)
  38. 10.1083/jcb.200803174 / J. Cell Biol. / Association between active genes occurs at nuclear speckles and is modulated by chromatin environment (2008)
  39. {'key': 'key\n\t\t\t\t20171219124455_B39', 'first-page': '167', 'article-title': 'Nucleation of nuclear bodies by RNA', 'volume': '13', 'year': '2010', 'journal-title': 'Nat. Cell Biol.'} / Nat. Cell Biol. / Nucleation of nuclear bodies by RNA (2010)
  40. 10.1096/fj.07-8377com / FASEB J. / Characterization of cyclin L1 as an immobile component of the splicing factor compartment (2007)
  41. 10.1083/jcb.200511038 / J. Cell Biol. / The Drosophila melanogaster Cajal body (2006)
  42. 10.1073/pnas.0807899106 / Proc. Natl. Acad. Sci. U.S.A. / MEN / noncoding RNAs are essential for structural integrity of nuclear paraspeckles (2009)
  43. 10.1016/S0960-9822(01)00632-7 / Curr. Biol. / Paraspeckles: a novel nuclear domain (2002)
  44. 10.1091/mbc.E11-05-0415 / Mol. Biol. Cell / RNA-related nuclear functions of human Pat1b, the P-body mRNA decay factor (2012)
  45. 10.1007/s00418-014-1274-2 / Histochem. Cell Biol. / The elastin peptide (VGVAPG)3 induces the 3D reorganisation of PML-NBs and SC35 speckles architecture, and accelerates proliferation of fibroblasts and melanoma cells (2015)
  46. 10.1074/jbc.M112.355412 / J. Biol. Chem. / Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion (2012)
  47. 10.1101/gad.12.1.55 / Genes Dev. / A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm (1998)
  48. 10.1074/jbc.274.16.11125 / J. Biol. Chem. / The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs) (1999)
  49. 10.1073/pnas.1017700108 / Proc. Natl. Acad. Sci. U.S.A. / Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly (2011)
  50. 10.1083/jcb.143.2.297 / J. Cell Biol. / Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo (1998)
  51. 10.1073/pnas.0403533101 / Proc. Natl. Acad. Sci. U.S.A. / A molecular link between SR protein dephosphorylation and mRNA export (2004)
  52. 10.1016/j.molcel.2008.03.013 / Mol. Cell / The splicing factor SF2/ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1 (2008)
  53. 10.1091/mbc.9.12.3547 / Mol. Biol. Cell / Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors (1998)
  54. 10.1016/S0014-4827(03)00115-0 / Exp. Cell Res. / Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus (2003)
  55. 10.1128/MCB.00355-07 / Mol. Cell. Biol. / Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17 (2007)
  56. 10.1007/s00018-009-0156-6 / Cell. Mol. Life Sci. / The PDZ2 domain of zonula occludens-1 and -2 is a phosphoinositide binding domain (2009)
  57. 10.1038/sj.emboj.7600722 / EMBO J. / Nuclear speckles and nucleoli targeting by PIP2-PDZ domain interactions (2005)
  58. 10.1038/nature06666 / Nature / A PtdIns4, 5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs (2008)
  59. 10.1073/pnas.1934680100 / Proc. Natl. Acad. Sci. U.S.A. / Nuclear actin and protein 4.1: essential interactions during nuclear assembly in vitro (2003)
  60. 10.1038/ncb1182 / Nat. Cell Biol. / Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II (2004)
  61. 10.1073/pnas.1131933100 / Proc. Natl. Acad. Sci. U.S.A. / An actin-ribonucleoprotein interaction is involved in transcription by RNA polymerase II (2003)
  62. 10.1002/jcb.21035 / J. Cell. Biochem. / Nuclear myosin I is necessary for the formation of the first phosphodiester bond during transcription initiation by RNA polymerase II (2006)
  63. 10.1016/j.yexcr.2006.07.028 / Exp. Cell Res. / Actin-based modeling of a transcriptionally competent nuclear substructure induced by transcription inhibition (2006)
  64. 10.1091/mbc.E12-09-0685 / Mol. Biol. Cell / Visualization of actin filaments and monomers in somatic cell nuclei (2013)
  65. 10.1091/mbc.E07-07-0637 / Mol. Biol. Cell / A novel role for PA28gamma-proteasome in nuclear speckle organization and SR protein trafficking (2008)
  66. 10.1101/gad.1925010 / Genes Dev. / The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome (2010)
  67. 10.1016/j.cell.2011.08.054 / Cell / ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs (2011)
  68. 10.1074/jbc.M109.063750 / J. Biol. Chem. / Differential effects of sumoylation on transcription and alternative splicing by transcription elongation regulator 1 (TCERG1) (2010)
  69. 10.1083/jcb.115.5.1191 / J. Cell Biol. / Discrete nuclear domains of poly(A) RNA and their relationship to the functional organization of the nucleus (1991)
  70. 10.1016/S1047-8477(02)00507-5 / J. Struct. Biol. / Evidence that all SC-35 domains contain mRNAs and that transcripts can be structurally constrained within these domains (2002)
  71. 10.1083/jcb.126.4.877 / J. Cell Biol. / In vivo analysis of the stability and transport of nuclear poly(A)+ RNA (1994)
  72. 10.1091/mbc.e05-10-0952 / Mol. Biol. Cell / Rapid, diffusional shuttling of Poly(A) RNA between nuclear speckles and the nucleoplasm (2006)
  73. 10.1126/science.1099754 / Science / Dynamics of single mRNPs in nuclei of living cells (2004)
  74. 10.1371/journal.pbio.0050322 / PLoS Biol. / The signal sequence coding region promotes nuclear export of mRNA (2007)
  75. 10.1083/jcb.200203046 / J. Cell Biol. / The intranuclear mobility of messenger RNA binding proteins is ATP dependent and temperature sensitive (2002)
  76. 10.1083/jcb.200310139 / J. Cell Biol. / Poly(A)+ RNAs roam the cell nucleus and pass through speckle domains in transcriptionally active and inactive cells (2004)
  77. 10.1111/j.1365-2443.2006.00936.x / Genes Cells / Nucleocytoplasmic transport of fluorescent mRNA in living mammalian cells: nuclear mRNA export is coupled to ongoing gene transcription (2006)
  78. 10.1016/0092-8674(94)90182-1 / Cell / Splicing of Balbiani ring 1 gene pre-mRNA occurs simultaneously with transcription (1994)
  79. 10.1038/372809a0 / Nature / Localization of pre-mRNA splicing in mammalian nuclei (1994)
  80. 10.1016/j.yexcr.2007.10.023 / Exp. Cell Res. / The dynamics of pre-mRNAs and poly(A)+ RNA at speckles in living cells revealed by iFRAP studies (2008)
  81. 10.1083/jcb.150.3.417 / J. Cell Biol. / Tracking COL1A1 RNA in osteogenesis imperfecta: splice-defective transcripts initiate transport from the gene but are retained within the SC35 domain (2000)
  82. 10.1091/mbc.E10-02-0105 / Mol. Biol. Cell / Nuclear organization and dynamics of 7SK RNA in regulating gene expression (2010)
  83. 10.1186/1471-2164-8-39 / BMC Genomics / A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains (2007)
  84. 10.1038/emboj.2010.199 / EMBO J. / A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression (2010)
  85. 10.1016/j.cell.2008.10.012 / Cell / 3′ end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA (2008)
  86. 10.1261/rna.028639.111 / RNA / Identification of cis- and trans-acting factors involved in the localization of MALAT-1 noncoding RNA to nuclear speckles (2012)
  87. 10.1186/gb-2012-13-3-r17 / Genome Biol. / The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes (2012)
  88. 10.1101/gr.082503.108 / Genome Res. / Splicing factor SFRS1 recognizes a functionally diverse landscape of RNA transcripts (2009)
  89. 10.1016/j.cell.2014.08.018 / Cell / RNA-RNA interactions enable specific targeting of noncoding RNAs to nascent Pre-mRNAs and chromatin sites (2014)
  90. 10.1016/j.molcel.2010.08.011 / Mol. Cell / The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation (2010)
  91. 10.1016/j.celrep.2012.06.003 / Cell Rep. / The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult (2012)
  92. 10.1261/rna.033217.112 / RNA / Malat1 is not an essential component of nuclear speckles in mice (2012)
  93. 10.1038/nsmb.2878 / Nat. Struct. Mol. Biol. / TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release (2014)
  94. 10.1038/385357a0 / Nature / The C-terminal domain of RNA polymerase II couples mRNA processing to transcription (1997)
  95. 10.1038/nsb0903-679 / Nat. Struct. Biol. / The CTD code (2003)
  96. 10.1093/nar/gks1327 / Nucleic Acids Res. / CTD serine-2 plays a critical role in splicing and termination factor recruitment to RNA polymerase II in vivo (2013)
  97. 10.1002/jcp.22096 / J. Cell. Physiol. / T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes (2010)
  98. 10.1093/nar/gku449 / Nucleic Acids Res. / Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation (2014)
  99. 10.1016/j.cell.2012.06.003 / Cell / RNA polymerase backtracking in gene regulation and genome instability (2012)
  100. 10.1016/j.cell.2005.06.008 / Cell / Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability (2005)
  101. 10.1083/jcb.200507073 / J. Cell Biol. / Coregulated human globin genes are frequently in spatial proximity when active (2006)
  102. 10.1016/j.cub.2014.03.053 / Curr. Biol. / HSP70 transgene directed motion to nuclear speckles facilitates heat shock activation (2014)
  103. 10.1007/s10577-010-9133-z / Chromosome Res. / Functional nuclear topography of transcriptionally inducible extra-chromosomal transgene clusters (2010)
  104. 10.1007/s00018-013-1465-3 / Cell. Mol. Life Sci. / Co-expressed genes prepositioned in spatial neighborhoods stochastically associate with SC35 speckles and RNA polymerase II factories (2014)
  105. 10.1101/gad.2.6.754 / Genes Dev. / Splice site selection, rate of splicing, and alternative splicing on nascent transcripts (1988)
  106. 10.1016/j.cell.2009.02.009 / Cell / The spliceosome: design principles of a dynamic RNP machine (2009)
  107. 10.1093/nar/gkv740 / Nucleic Acids Res. / Splicing inhibition decreases phosphorylation level of Ser2 in Pol II CTD (2015)
  108. 10.1073/pnas.0903188106 / Proc. Natl. Acad. Sci. U.S.A. / 7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development (2009)
  109. 10.1016/j.molcel.2007.05.036 / Mol. Cell / SR proteins function in coupling RNAP II transcription to pre-mRNA splicing (2007)
  110. 10.1101/gad.2038011 / Genes Dev. / The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex (2011)
  111. 10.1016/j.molcel.2010.11.005 / Mol. Cell / Splicing-dependent RNA polymerase pausing in yeast (2010)
  112. 10.1128/MCB.21.22.7617-7628.2001 / Mol. Cell. Biol. / The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1 (2001)
  113. 10.1038/nsmb1030 / Nat. Struct. Mol. Biol. / The human SWI/SNF subunit Brm is a regulator of alternative splicing (2006)
  114. 10.1038/nature10925 / Nature / DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation (2012)
  115. 10.1038/nsmb.1995 / Nat. Struct. Mol. Biol. / Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons (2011)
  116. 10.1073/pnas.0810666106 / Proc. Natl. Acad. Sci. U.S.A. / Neuronal cell depolarization induces intragenic chromatin modifications affecting NCAM alternative splicing (2009)
  117. 10.1016/j.molcel.2009.02.003 / Mol. Cell / Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation (2009)
  118. 10.1093/nar/gkt1134 / Nucleic Acids Res. / RNA-dependent dynamic histone acetylation regulates MCL1 alternative splicing (2014)
  119. 10.1128/MCB.21.20.6782-6795.2001 / Mol. Cell. Biol. / Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo (2001)
  120. 10.1074/jbc.M609809200 / J. Biol. Chem. / Identification and characterization of the human set1B histone H3-Lys4 methyltransferase complex (2007)
  121. 10.3390/biom5042935 / Biomolecules / The RNA splicing response to DNA damage (2015)
  122. 10.1093/nar/gkv844 / Nucleic Acids Res. / Involvement of SRSF11 in cell cycle-specific recruitment of telomerase to telomeres at nuclear speckles (2015)
  123. 10.1038/ng.2007.57 / Nat. Genet. / Genome-wide analysis of transcript isoform variation in humans (2008)
  124. 10.1101/gad.269415.115 / Genes Dev. / A majority of m 6 A residues are in the last exons, allowing the potential for 3′ UTR regulation (2015)
  125. 10.1101/gr.075804.107 / Genome Res. / A genomic analysis of RNA polymerase II modification and chromatin architecture related to 3′ end RNA polyadenylation (2008)
  126. 10.1128/MCB.01410-07 / Mol. Cell. Biol. / Functional coupling of last-intron splicing and 3′-end processing to transcription in vitro: the Poly(A) signal couples to splicing before committing to cleavage (2008)
  127. 10.1101/gad.14.4.403 / Genes Dev. / The carboxyl terminus of vertebrate poly(A) polymerase interacts with U2AF 65 to couple 3′-end processing and splicing (2000)
  128. 10.1101/gad.10.3.325 / Genes Dev. / Interaction between the U1 snRNP-A protein and the 160-kD subunit of cleavage-polyadenylation specificity factor increases polyadenylation efficiency in vitro (1996)
  129. 10.1038/nchembio.687 / Nat. Chem. Biol. / N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO (2011)
  130. 10.1016/j.molcel.2012.10.015 / Mol. Cell / ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility (2013)
  131. 10.1038/nchembio.1654 / Nat. Chem. Biol. / Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain (2014)
  132. 10.1038/nature14234 / Nature / N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions (2015)
  133. 10.1093/emboj/19.24.6860 / EMBO J. / The spliceosome deposits multiple proteins 20–24 nucleotides upstream of mRNA exon-exon junctions (2000)
  134. 10.1016/S1097-2765(00)00065-4 / Mol. Cell / Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm (2000)
  135. 10.1167/iovs.03-0240 / Invest. Ophthalmol. Vis. Sci. / Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells (2003)
  136. 10.1242/jcs.055889 / J. Cell Sci. / Human RBMY regulates germline-specific splicing events by modulating the function of the serine/arginine-rich proteins 9G8 and Tra2-{beta} (2010)
  137. 10.1038/35098106 / Nature / Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly (2001)
  138. 10.1038/nature746 / Nature / TREX is a conserved complex coupling transcription with messenger RNA export (2002)
  139. 10.1101/gad.1302205 / Genes Dev. / Recruitment of the human TREX complex to mRNA during splicing (2005)
  140. 10.1038/ncomms2005 / Nat. Commun. / TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export (2012)
  141. 10.1016/j.cell.2006.10.044 / Cell / Human mRNA export machinery recruited to the 5′ end of mRNA (2006)
  142. 10.1016/j.cell.2008.08.005 / Cell / THO/Sub2p functions to coordinate 3′-end processing with gene-nuclear pore association (2008)
  143. 10.1073/pnas.0800250105 / Proc. Natl. Acad. Sci. U.S.A. / Splicing promotes rapid and efficient mRNA export in mammalian cells (2008)
  144. 10.1101/gad.852101 / Genes Dev. / Multiple roles for the yeast SUB2/yUAP56 gene in splicing (2001)
  145. 10.1371/journal.pgen.1003914 / PLoS Genet. / Recruitment of TREX to the transcription machinery by its direct binding to the phospho-CTD of RNA Polymerase II (2013)
  146. 10.1101/gad.623411 / Genes Dev. / The Prp19 complex is a novel transcription elongation factor required for TREX occupancy at transcribed genes (2011)
  147. 10.1016/S1097-2765(03)00089-3 / Mol. Cell / SR splicing factors serve as adapter proteins for TAP-dependent mRNA export (2003)
  148. 10.1093/nar/gks1314 / Nucleic Acids Res. / Evidence that a consensus element found in naturally intronless mRNAs promotes mRNA export (2013)
  149. {'key': 'key\n\t\t\t\t20171219124455_B149', 'first-page': 'e1411', 'article-title': 'The exon junction complex: a lifelong guardian of mRNA fate', 'volume': '8', 'year': '2016', 'journal-title': 'Wiley Interdiscip. Rev. RNA'} / Wiley Interdiscip. Rev. RNA / The exon junction complex: a lifelong guardian of mRNA fate (2016)
  150. {'key': 'key\n\t\t\t\t20171219124455_B150', 'first-page': '976', 'article-title': 'The role of nuclear bodies in gene expression and disease', 'volume': '2', 'year': '2013', 'journal-title': 'Biology (Basel)'} / Biology (Basel) / The role of nuclear bodies in gene expression and disease (2013)
  151. 10.1038/ng.1032 / Nat. Genet. / Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia (2011)
  152. 10.1038/nature10496 / Nature / Frequent pathway mutations of splicing machinery in myelodysplasia (2011)
  153. 10.1261/rna.057919.116 / RNA / Splicing-factor alterations in cancers (2016)
  154. 10.1038/nsmb.2207 / Nat. Struct. Mol. Biol. / The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation (2012)
  155. 10.1016/j.celrep.2014.03.041 / Cell Rep. / Mnk2 alternative splicing modulates the p38-MAPK pathway and impacts ras-induced transformation (2014)
  156. 10.1158/0008-5472.CAN-10-4410 / Cancer Res. / Splicing factor hnRNP A2/B1 regulates tumor suppressor gene splicing and is an oncogenic driver in glioblastoma (2011)
  157. 10.1016/j.cell.2009.06.016 / Cell / Widespread shortening of 3′UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells (2009)
  158. 10.1016/j.tig.2017.03.001 / Trends Genet. / Splicing factor mutations in myelodysplasias: insights from spliceosome structures (2017)
  159. 10.1038/nmicrobiol.2016.69 / Nat. Microbiol. / Influenza virus mRNA trafficking through host nuclear speckles (2016)
  160. 10.4161/rna.8.2.13984 / RNA Biol. / Identification of protein partners of the human immunodeficiency virus 1 tat/rev exon 3 leads to the discovery of a new HIV-1 splicing regulator, protein hnRNP K (2011)
  161. 10.1111/j.1742-4658.2009.07522.x / FEBS J. / Alternative splicing: regulation of HIV-1 multiplication as a target for therapeutic action (2010)
  162. 10.1038/sj.emboj.7601494 / EMBO J. / A nucleo-cytoplasmic SR protein functions in viral IRES-mediated translation initiation (2007)
  163. 10.1186/1742-4690-5-18 / Retrovirology / HIV-1 infection induces changes in expression of cellular splicing factors that regulate alternative viral splicing and virus production in macrophages (2008)
  164. 10.1128/JVI.69.1.281-290.1995 / J. Virol. / Dynamic organization of splicing factors in adenovirus-infected cells (1995)
  165. 10.1016/S1097-2765(00)80099-4 / Mol. Cell / Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3′ end formation of cellular pre-mRNAs (1998)
  166. {'key': 'key\n\t\t\t\t20171219124455_B166', 'article-title': 'A cytoplasmic RNA virus alters the function of the cell splicing protein SRSF2', 'volume': '91', 'year': '2017', 'journal-title': 'J. Virol.'} / J. Virol. / A cytoplasmic RNA virus alters the function of the cell splicing protein SRSF2 (2017)
  167. 10.1073/pnas.1310249110 / Proc. Natl. Acad. Sci. U.S.A. / U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease (2013)
  168. 10.1093/hmg/ddh054 / Hum. Mol. Genet. / A phosphorylated, carboxy-terminal fragment of beta-amyloid precursor protein localizes to the splicing factor compartment (2004)
  169. 10.1007/s00401-002-0587-8 / Acta Neuropathol. / Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration (2002)
  170. 10.1074/jbc.M311512200 / J. Biol. Chem. / Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease (2004)
  171. 10.1016/j.neurobiolaging.2016.07.014 / Neurobiol. Aging / Parkinson's disease-related gene variants influence pre-mRNA splicing processes (2016)
  172. 10.1007/s10048-015-0449-x / Neurogenetics / Splicing: is there an alternative contribution to Parkinson's disease (2015)
  173. 10.1073/pnas.212483099 / Proc. Natl. Acad. Sci. U.S.A. / Higher order arrangement of the eukaryotic nuclear bodies (2002)
  174. 10.1001/archneur.64.10.1388 / Arch. Neurol. / TDP-43 proteinopathy in frontotemporal lobar degeneration and amyotrophic lateral sclerosis: protein misfolding diseases without amyloidosis (2007)
  175. 10.1093/hmg/ddt319 / Hum. Mol. Genet. / The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons (2013)
  176. 10.1038/nn.2778 / Nat. Neurosci. / Characterizing the RNA targets and position-dependent splicing regulation by TDP-43 (2011)
  177. 10.1038/nn.2779 / Nat. Neurosci. / Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43 (2011)
  178. 10.1126/science.aab0983 / Science / TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD (2015)
  179. 10.1038/nn.3230 / Nat. Neurosci. / Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs (2012)
  180. 10.1093/hmg/ddt117 / Hum. Mol. Genet. / ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules (2013)
  181. 10.1006/excr.2000.4858 / Exp. Cell Res. / The relationship between SMN, the spinal muscular atrophy protein, and nuclear coiled bodies in differentiated tissues and cultured cells (2000)
  182. 10.1006/excr.2001.5186 / Exp. Cell Res. / Nuclear gems and Cajal (coiled) bodies in fetal tissues: nucleolar distribution of the spinal muscular atrophy protein, SMN (2001)
  183. 10.1016/j.bbamcr.2008.05.005 / Biochim. Biophys. Acta / Nuclear bodies in neurodegenerative disease (2008)
  184. 10.1093/hmg/ddt035 / Hum. Mol. Genet. / Contribution of copy number variants involving nonsense-mediated mRNA decay pathway genes to neuro-developmental disorders (2013)
  185. 10.1016/j.ajhg.2013.11.020 / Am. J. Hum. Genet. / A noncoding expansion in EIF4A3 causes Richieri-Costa-Pereira syndrome, a craniofacial disorder associated with limb defects (2014)
  186. 10.1016/j.ijdevneu.2016.03.006 / Int. J. Dev. Neurosci. / The exon junction complex in neural development and neurodevelopmental disease (2016)
  187. 10.1038/tp.2015.74 / Transl. Psychiatry / Glutamate transporter splice variant expression in an enriched pyramidal cell population in schizophrenia (2015)
  188. 10.1016/j.jpsychires.2014.01.011 / J. Psychiatr. Res. / Combined analysis of exon splicing and genome wide polymorphism data predict schizophrenia risk loci (2014)
  189. 10.1016/j.cell.2014.11.035 / Cell / A highly conserved program of neuronal microexons is misregulated in autistic brains (2014)
  190. 10.1101/gad.256115.114 / Genes Dev. / Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development (2015)
  191. 10.1083/jcb.128.6.995 / J. Cell Biol. / Foci of trinucleotide repeat transcripts in nuclei of myotonic dystrophy cells and tissues (1995)
  192. 10.1111/j.1365-2443.2007.01112.x / Genes Cells / Defective mRNA in myotonic dystrophy accumulates at the periphery of nuclear splicing speckles (2007)
  193. 10.1016/j.bbadis.2016.05.015 / Biochim. Biophys. Acta / Nuclear speckles are detention centers for transcripts containing expanded CAG repeats (2016)
  194. 10.1083/jcb.200706048 / J. Cell Biol. / Defining early steps in mRNA transport: mutant mRNA in myotonic dystrophy type I is blocked at entry into SC-35 domains (2007)
  195. 10.1016/j.ymeth.2015.11.017 / Methods / RNA FISH for detecting expanded repeats in human diseases (2016)
  196. 10.1038/nature22386 / Nature / RNA phase transitions in repeat expansion disorders (2017)
  197. 10.1038/nm.3617 / Nat. Med. / Huntington's disease is a four-repeat tauopathy with tau nuclear rods (2014)
  198. 10.4161/rna.26706 / RNA Biol. / Aberrantly spliced HTT, a new player in Huntington's disease pathogenesis (2013)
  199. 10.1038/emboj.2010.21 / EMBO J. / Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients (2010)
  200. 10.1016/j.celrep.2013.10.049 / Cell Rep. / Hexanucleotide repeats in ALS/FTD form length-dependent RNA foci, sequester RNA binding proteins, and are neurotoxic (2013)
  201. 10.1515/hsz-2012-0218 / Biol. Chem. / Triplet repeats in transcripts: structural insights into RNA toxicity (2012)
  202. 10.1093/nar/gkw703 / Nucleic Acids Res. / Nuclear poly(A)-binding protein aggregates misplace a pre-mRNA outside of SC35 speckle causing its abnormal splicing (2016)
  203. 10.1093/hmg/10.11.1129 / Hum. Mol. Genet. / The product of an oculopharyngeal muscular dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression (2001)
  204. 10.1038/nbt1210-1248 / Nat. Biotechnol. / Towards a knowledge-based Human Protein Atlas (2010)
  205. 10.1038/cr.2017.9 / Cell Res. / Painting a specific chromosome with CRISPR/Cas9 for live-cell imaging (2017)
  206. 10.1016/j.tcb.2015.10.004 / Trends Cell Biol. / Super-resolution microscopy: from single molecules to supramolecular assemblies (2015)
  207. {'key': 'key\n\t\t\t\t20171219124455_B207', 'article-title': 'Cryo-electron microscopy for structural analysis of dynamic biological macromolecules', 'year': '2017', 'journal-title': 'Biochim. Biophys. Acta'} / Biochim. Biophys. Acta / Cryo-electron microscopy for structural analysis of dynamic biological macromolecules (2017)
  208. 10.1146/annurev-biochem-061516-044741 / Annu. Rev. Biochem. / Cellular electron cryotomography: toward structural biology in situ (2017)
  209. 10.1016/j.molcel.2004.07.022 / Mol. Cell / Three-dimensional structure of the native spliceosome by cryo-electron microscopy (2004)
  210. 10.1038/ncomms6294 / Nat. Commun. / The molecular structure of the left-handed supra-molecular helix of eukaryotic polyribosomes (2014)
  211. 10.1038/nature14427 / Nature / Structure of the human 80S ribosome (2015)
  212. 10.1016/j.cell.2017.04.033 / Cell / An atomic structure of the human spliceosome (2017)
  213. 10.1016/j.csbj.2016.10.002 / Comput. Struct. Biotechnol. J. / Cryo-electron microscopy analysis of structurally heterogeneous macromolecular complexes (2016)
  214. 10.1038/nmeth1014 / Nat. Methods / Focused-ion-beam thinning of frozen-hydrated biological specimens for cryo-electron microscopy (2007)
  215. 10.1126/science.1261197 / Science / Proteasomes. A molecular census of 26S proteasomes in intact neurons (2015)
Dates
Type When
Created 8 years ago (Aug. 18, 2017, 7:36 a.m.)
Deposited 1 year, 1 month ago (June 26, 2024, 6:34 a.m.)
Indexed 1 hour, 12 minutes ago (Aug. 21, 2025, 10:23 a.m.)
Issued 7 years, 11 months ago (Sept. 1, 2017)
Published 7 years, 11 months ago (Sept. 1, 2017)
Published Online 7 years, 11 months ago (Sept. 1, 2017)
Published Print 7 years, 10 months ago (Oct. 13, 2017)
Funders 0

None

@article{Galganski_2017, title={Nuclear speckles: molecular organization, biological function and role in disease}, volume={45}, ISSN={1362-4962}, url={http://dx.doi.org/10.1093/nar/gkx759}, DOI={10.1093/nar/gkx759}, number={18}, journal={Nucleic Acids Research}, publisher={Oxford University Press (OUP)}, author={Galganski, Lukasz and Urbanek, Martyna O. and Krzyzosiak, Wlodzimierz J.}, year={2017}, month=sep, pages={10350–10368} }