DOI: 10.1093/nar/gkr156. Inhibition of mutant huntingtin expression by RNA duplex targeting expanded CAG repeats

Inhibition of mutant huntingtin expression by RNA duplex targeting expanded CAG repeats

10.1093/nar/gkr156

Crossref journal-article

Oxford University Press (OUP)

Nucleic Acids Research (286)

Bibliography

Fiszer, A., Mykowska, A., & Krzyzosiak, W. J. (2011). Inhibition of mutant huntingtin expression by RNA duplex targeting expanded CAG repeats. Nucleic Acids Research, 39(13), 5578â5585.

Authors 3

Agnieszka Fiszer (first)
Agnieszka Mykowska (additional)
Wlodzimierz J. Krzyzosiak (additional)

References 32 Referenced 62

10.1038/nature05977 / Nature / Expandable DNA repeats and human disease by Mirkin (2007)
10.1111/j.1471-4159.2009.06302.x / J. Neurochem. / The pathogenic mechanisms of polyglutamine diseases and current therapeutic strategies by Bauer (2009)
10.1002/ana.21948 / Ann. Neurol. / RNA-mediated neurodegeneration in repeat expansion disorders by Todd (2010)
10.1371/journal.pone.0003341 / PLoS ONE / Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease by Alves (2008)
10.1073/pnas.1231012100 / Proc. Natl Acad. Sci. USA / Allele-specific silencing of dominant disease genes by Miller (2003)
10.1016/j.cub.2009.03.030 / Curr. Biol. / Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients by Pfister (2009)
10.1093/nar/gki312 / Nucleic Acids Res. / A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites by Du (2005)
10.1093/nar/gkp835 / Nucleic Acids Res. / Profiling of mismatch discrimination in RNAi enabled rational design of allele-specific siRNAs by Huang (2009)
10.1371/journal.pgen.0020140 / PLoS Genet. / Designing siRNA that distinguish between genes that differ by a single nucleotide by Schwarz (2006)
10.1016/j.ajhg.2009.02.003 / Am. J. Hum. Genet. / CAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroup by Warby (2009)
10.1073/pnas.0708285104 / Proc. Natl Acad. Sci. USA / Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits by DiFiglia (2007)
10.1016/j.bbrc.2006.02.141 / Biochem. Biophys. Res. Commun. / rAAV-mediated shRNA ameliorated neuropathology in Huntington disease model mouse by Machida (2006)
10.1016/j.neures.2005.06.021 / Neurosci. Res. / Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA by Wang (2005)
10.1038/mt.2009.17 / Mol. Ther. / Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice by Boudreau (2009)
10.1038/nbt.1539 / Nat. Biotechnol. / Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs by Hu (2009)
10.1002/humu.20466 / Hum. Mutat. / CAG and CTG repeat polymorphism in exons of human genes shows distinct features at the expandable loci by Rozanska (2007)
10.1093/nar/gkq127 / Nucleic Acids Res. / Trinucleotide repeats in human genome and exome by Kozlowski (2010)
10.1038/mt.2008.298 / Mol. Ther. / Asymmetric shorter-duplex siRNA structures trigger efficient gene silencing with reduced nonspecific effects by Chang (2009)
10.1038/nbt.1512 / Nat. Biotechnol. / Asymmetric RNA duplexes mediate RNA interference in mammalian cells by Sun (2008)
10.1038/nature09267 / Nature / Mammalian microRNAs predominantly act to decrease target mRNA levels by Guo (2010)
10.1101/gad.1064703 / Genes Dev. / siRNAs can function as miRNAs by Doench (2003)
10.1093/nar/gkm133 / Nucleic Acids Res. / Distance constraints between microRNA target sites dictate efficacy and cooperativity by Saetrom (2007)
10.1093/nar/gkq1323 / Nucleic Acids Res. / Mutant CAG repeats of Huntingtin transcript fold into hairpins, form nuclear foci and are targets for RNA interference by de Mezer (2011)
10.1016/j.molcel.2007.01.031 / Mol. Cell. / Ribonuclease dicer cleaves triplet repeat hairpins into shorter repeats that silence specific targets by Krol (2007)
10.1016/j.jmb.2004.05.021 / J. Mol. Biol. / Molecular architecture of CAG repeats in human disease related transcripts by Michlewski (2004)
10.1093/hmg/ddq132 / Hum. Mol. Genet. / Partners in crime: bidirectional transcription in unstable microsatellite disease by Batra (2010)
10.1074/jbc.M307089200 / J. Biol. Chem. / Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells by Saxena (2003)
10.1073/pnas.1630797100 / Proc. Natl Acad. Sci. USA / MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms by Zeng (2003)
10.1158/1535-7163.MCT-07-2312 / Mol. Cancer Ther. / Antitumor effect of dsRNA-induced p21(WAF1/CIP1) gene activation in human bladder cancer cells by Chen (2008)
10.1038/nchembio860 / Nat. Chem. Biol. / Activating gene expression in mammalian cells with promoter-targeted duplex RNAs by Janowski (2007)
10.1073/pnas.0607015103 / Proc. Natl Acad. Sci. USA / Small dsRNAs induce transcriptional activation in human cells by Li (2006)
10.1371/journal.pgen.1000258 / PLoS Genet. / Bidirectional transcription directs both transcriptional gene activation and suppression in human cells by Morris (2008)

Dates

Type	When
Created	14 years, 5 months ago (March 22, 2011, 8:21 p.m.)
Deposited	1 year, 4 months ago (April 5, 2024, 6:38 a.m.)
Indexed	2 months, 2 weeks ago (June 10, 2025, 11:04 a.m.)
Issued	14 years, 5 months ago (March 22, 2011)
Published	14 years, 5 months ago (March 22, 2011)
Published Online	14 years, 5 months ago (March 22, 2011)
Published Print	14 years, 1 month ago (July 1, 2011)

Funders 0

None

BibTeX

@article{Fiszer_2011, title={Inhibition of mutant huntingtin expression by RNA duplex targeting expanded CAG repeats}, volume={39}, ISSN={0305-1048}, url={http://dx.doi.org/10.1093/nar/gkr156}, DOI={10.1093/nar/gkr156}, number={13}, journal={Nucleic Acids Research}, publisher={Oxford University Press (OUP)}, author={Fiszer, Agnieszka and Mykowska, Agnieszka and Krzyzosiak, Wlodzimierz J.}, year={2011}, month=mar, pages={5578–5585} }

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