DOI: 10.1093/nar/gkm593. Avoiding false-positive signals with nuclease-vulnerable molecular beacons in single living cells

Avoiding false-positive signals with nuclease-vulnerable molecular beacons in single living cells

10.1093/nar/gkm593

Crossref journal-article

Oxford University Press (OUP)

Nucleic Acids Research (286)

Bibliography

Chen, A. K., Behlke, M. A., & Tsourkas, A. (2007). Avoiding false-positive signals with nuclease-vulnerable molecular beacons in single living cells. Nucleic Acids Research, 35(16), e105.

Authors 3

Antony K. Chen (first)
Mark A. Behlke (additional)
Andrew Tsourkas (additional)

References 39 Referenced 121

10.1073/pnas.94.3.814 / Proc. Natl Acad. Sci. USA / Stochastic mechanisms in gene expression by McAdams (1997)
10.1038/nature01546 / Nature / Noise in eukaryotic gene expression by Blake (2003)
10.1182/blood.V96.7.2323 / Blood / Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression by Hume (2000)
10.1038/icb.1994.26 / Immunol. Cell. Biol / Transcription of individual genes in eukaryotic cells occurs randomly and infrequently by Ross (1994)
10.1016/S0006-3495(01)75949-8 / Biophys. J / Stochasticity in transcriptional regulation: origins, consequences, and mathematical representations by Kepler (2001)
10.1073/pnas.162041399 / Proc. Natl Acad. Sci. USA / Intrinsic and extrinsic contributions to stochasticity in gene expression by Swain (2002)
10.1038/nbt0396-303 / Nat. Biotechnol / Molecular beacons: probes that fluoresce upon hybridization by Tyagi (1996)
10.1529/biophysj.104.045153 / Biophys. J / Imaging native beta-actin mRNA in motile fibroblasts by Tyagi (2004)
10.1073/pnas.2233244100 / Proc. Natl Acad. Sci. USA / Visualizing the distribution and transport of mRNAs in living cells by Bratu (2003)
10.1093/nar/gnh062 / Nucleic Acids Res / Dual FRET molecular beacons for mRNA detection in living cells by Santangelo (2004)
10.1021/ac010633b / Anal. Chem / Real-time monitoring of intracellular mRNA hybridization inside single living cells by Perlette (2001)
10.1093/nar/gnh063 / Nucleic Acids Res / Peptide-linked molecular beacons for efficient delivery and rapid mRNA detection in living cells by Nitin (2004)
10.1093/nar/gki302 / Nucleic Acids Res / tRNA-linked molecular beacons for imaging mRNAs in the cytoplasm of living cells by Mhlanga (2005)
10.1073/pnas.0505580102 / Proc. Natl Acad. Sci. USA / Mechanism of mRNA transport in the nucleus by Vargas (2005)
10.1128/JVI.80.2.682-688.2006 / J. Virol / Live-cell characterization and analysis of a clinical isolate of bovine respiratory syncytial virus, using molecular beacons by Santangelo (2006)
10.1158/0008-5472.CAN-04-3196 / Cancer Res / Real-time detection of gene expression in cancer cells using molecular beacon imaging: new strategies for cancer research by Peng (2005)
10.1021/ac050881y / Anal. Chem / Simultaneous monitoring of the expression of multiple genes inside of single breast carcinoma cells by Medley (2005)
10.1002/cbic.200500046 / Chembiochem / Stochasticity of manganese superoxide dismutase mRNA expression in breast carcinoma cells by molecular beacon imaging by Drake (2005)
10.1002/(SICI)1521-3773(20000317)39:6<1049::AID-ANIE1049>3.0.CO;2-2 / Angew. Chem. Int. Ed. Engl / Molecular beacons: a novel approach to detect protein - DNA interactions. This work was partially supported by a U.S. NSF Career Award (CHE-9733650) and by a U.S. Office of Naval Research Young Investigator Award (N00014-98-1-0621) by Li (2000)
10.1093/nar/28.11.e52 / Nucleic Acids Res / Using molecular beacons as a sensitive fluorescence assay for enzymatic cleavage of single-stranded DNA by Li (2000)
10.1093/nar/29.17.e89 / Nucleic Acids Res / Linear 2′ O-Methyl RNA probes for the visualization of RNA in living cells by Molenaar (2001)
10.1038/sj.onc.1201939 / Oncogene / Involvement of Myc targets in c-myc and N-myc induced human tumors by Ben-Yosef (1998)
10.1016/S0021-9258(18)37810-4 / J. Biol. Chem / Transcriptional regulation of c-myc oncogene expression by estrogen in hormone-responsive human breast cancer cells by Dubik (1988)
10.1002/path.1385 / J. Pathol / Association of C-MYC amplification with progression from the in situ to the invasive stage in C-MYC-amplified breast carcinomas by Robanus-Maandag (2003)
10.1016/j.cancergencyto.2005.08.013 / Cancer Genet. Cytogenet / The MYC oncogene in breast cancer progression: from benign epithelium to invasive carcinoma by Corzo (2006)
10.1038/sj.bjc.6601703 / Br. J. Cancer / Correlation of amplification and overexpression of the c-myc oncogene in high-grade breast cancer: FISH, in situ hybridisation and immunohistochemical analyses by Blancato (2004)
10.1016/j.mcp.2006.09.001 / Mol. Cell. Probes / Optimized linkage and quenching strategies for quantum dot molecular beacons by Cady (2007)
10.1073/pnas.83.8.2496 / Proc. Natl Acad. Sci. USA / Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture by Berthois (1986)
10.1158/0008-5472.18.65.1 / Cancer Res / The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer by Chu (2005)
10.1093/nar/15.7.2911 / Nucleic Acids Res / Rapid hybridization kinetics of DNA attached to submicron latex particles by Wolf (1987)
10.1006/abio.1999.4344 / Anal. Biochem / Real-time measurements of DNA hybridization on microparticles with fluorescence resonance energy transfer by Henry (1999)
10.1016/S0021-9258(18)47090-1 / J. Biol. Chem / Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding by Brown (1994)
10.1093/nar/21.16.3857 / Nucleic Acids Res / Intracellular disposition and metabolism of fluorescently-labeled unmodified and modified oligonucleotides microinjected into mammalian cells by Fisher (1993)
10.1158/1535-7163.MCT-05-0046 / Mol. Cancer Ther / Selenium disrupts estrogen receptor (alpha) signaling and potentiates tamoxifen antagonism in endometrial cancer cells and tamoxifen-resistant breast cancer cells by Shah (2005)
10.1002/ijc.11263 / Int. J. Cancer / Additive effects of tamoxifen and the farnesyl transferase inhibitor FTI-277 on inhibition of MCF-7 breast cancer cell-cycle progression by Doisneau-Sixou (2003)
10.1128/AEM.71.7.3866-3871.2005 / Appl. Environ. Microbiol / An internal reference technique for accurately quantifying specific mRNAs by real-time PCR with application to the tceA reductive dehalogenase gene by Johnson (2005)
10.1373/clinchem.2005.048983 / Clin. Chem / Quantification of mRNA in whole blood by assessing recovery of RNA and efficiency of cDNA synthesis by Mitsuhashi (2006)
10.1021/bc0497923 / Bioconjug. Chem / Noninvasive molecular imaging of MYC mRNA expression in human breast cancer xenografts with a [99mTc]peptide-peptide nucleic acid-peptide chimera by Tian (2005)
10.1196/annals.1339.038 / Ann. N.Y. Acad. Sci / External imaging of CCND1, MYC, and KRAS oncogene mRNAs with tumor-targeted radionuclide-PNA-peptide chimeras by Tian (2005)

Dates

Type	When
Created	18 years ago (Aug. 16, 2007, 8:14 p.m.)
Deposited	2 years, 3 months ago (May 13, 2023, 4:33 p.m.)
Indexed	3 months, 4 weeks ago (May 8, 2025, 3:26 p.m.)
Issued	18 years, 1 month ago (Aug. 1, 2007)
Published	18 years, 1 month ago (Aug. 1, 2007)
Published Online	18 years ago (Aug. 15, 2007)
Published Print	18 years, 1 month ago (Aug. 1, 2007)

Funders 0

None

BibTeX

@article{Chen_2007, title={Avoiding false-positive signals with nuclease-vulnerable molecular beacons in single living cells}, volume={35}, ISSN={0305-1048}, url={http://dx.doi.org/10.1093/nar/gkm593}, DOI={10.1093/nar/gkm593}, number={16}, journal={Nucleic Acids Research}, publisher={Oxford University Press (OUP)}, author={Chen, Antony K. and Behlke, Mark A. and Tsourkas, Andrew}, year={2007}, month=aug, pages={e105} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        5,
        8
      ]
    ],
    "date-time": "2025-05-08T19:26:00Z",
    "timestamp": 1746732360517
  },
  "reference-count": 39,
  "publisher": "Oxford University Press (OUP)",
  "issue": "16",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2007,
        8
      ]
    ]
  },
  "DOI": "10.1093/nar/gkm593",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2007,
        8,
        17
      ]
    ],
    "date-time": "2007-08-17T00:14:22Z",
    "timestamp": 1187309662000
  },
  "page": "e105",
  "source": "Crossref",
  "is-referenced-by-count": 121,
  "title": "Avoiding false-positive signals with nuclease-vulnerable molecular beacons in single living cells",
  "prefix": "10.1093",
  "volume": "35",
  "author": [
    {
      "given": "Antony K.",
      "family": "Chen",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Mark A.",
      "family": "Behlke",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Andrew",
      "family": "Tsourkas",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "286",
  "published-online": {
    "date-parts": [
      [
        2007,
        8,
        15
      ]
    ]
  },
  "reference": [
    {
      "key": "key\n\t\t\t\t20170720102446_B1",
      "doi-asserted-by": "crossref",
      "first-page": "814",
      "DOI": "10.1073/pnas.94.3.814",
      "article-title": "Stochastic mechanisms in gene expression",
      "volume": "94",
      "author": "McAdams",
      "year": "1997",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B2",
      "doi-asserted-by": "crossref",
      "first-page": "633",
      "DOI": "10.1038/nature01546",
      "article-title": "Noise in eukaryotic gene expression",
      "volume": "422",
      "author": "Blake",
      "year": "2003",
      "journal-title": "Nature"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B3",
      "doi-asserted-by": "crossref",
      "first-page": "2323",
      "DOI": "10.1182/blood.V96.7.2323",
      "article-title": "Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression",
      "volume": "96",
      "author": "Hume",
      "year": "2000",
      "journal-title": "Blood"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B4",
      "doi-asserted-by": "crossref",
      "first-page": "177",
      "DOI": "10.1038/icb.1994.26",
      "article-title": "Transcription of individual genes in eukaryotic cells occurs randomly and infrequently",
      "volume": "72",
      "author": "Ross",
      "year": "1994",
      "journal-title": "Immunol. Cell. Biol"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B5",
      "doi-asserted-by": "crossref",
      "first-page": "3116",
      "DOI": "10.1016/S0006-3495(01)75949-8",
      "article-title": "Stochasticity in transcriptional regulation: origins, consequences, and mathematical representations",
      "volume": "81",
      "author": "Kepler",
      "year": "2001",
      "journal-title": "Biophys. J"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B6",
      "doi-asserted-by": "crossref",
      "first-page": "12795",
      "DOI": "10.1073/pnas.162041399",
      "article-title": "Intrinsic and extrinsic contributions to stochasticity in gene expression",
      "volume": "99",
      "author": "Swain",
      "year": "2002",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B7",
      "doi-asserted-by": "crossref",
      "first-page": "303",
      "DOI": "10.1038/nbt0396-303",
      "article-title": "Molecular beacons: probes that fluoresce upon hybridization",
      "volume": "14",
      "author": "Tyagi",
      "year": "1996",
      "journal-title": "Nat. Biotechnol"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B8",
      "doi-asserted-by": "crossref",
      "first-page": "4153",
      "DOI": "10.1529/biophysj.104.045153",
      "article-title": "Imaging native beta-actin mRNA in motile fibroblasts",
      "volume": "87",
      "author": "Tyagi",
      "year": "2004",
      "journal-title": "Biophys. J"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B9",
      "doi-asserted-by": "crossref",
      "first-page": "13308",
      "DOI": "10.1073/pnas.2233244100",
      "article-title": "Visualizing the distribution and transport of mRNAs in living cells",
      "volume": "100",
      "author": "Bratu",
      "year": "2003",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B10",
      "doi-asserted-by": "crossref",
      "first-page": "e57",
      "DOI": "10.1093/nar/gnh062",
      "article-title": "Dual FRET molecular beacons for mRNA detection in living cells",
      "volume": "32",
      "author": "Santangelo",
      "year": "2004",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B11",
      "doi-asserted-by": "crossref",
      "first-page": "5544",
      "DOI": "10.1021/ac010633b",
      "article-title": "Real-time monitoring of intracellular mRNA hybridization inside single living cells",
      "volume": "73",
      "author": "Perlette",
      "year": "2001",
      "journal-title": "Anal. Chem"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B12",
      "doi-asserted-by": "crossref",
      "first-page": "e58",
      "DOI": "10.1093/nar/gnh063",
      "article-title": "Peptide-linked molecular beacons for efficient delivery and rapid mRNA detection in living cells",
      "volume": "32",
      "author": "Nitin",
      "year": "2004",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B13",
      "doi-asserted-by": "crossref",
      "first-page": "1902",
      "DOI": "10.1093/nar/gki302",
      "article-title": "tRNA-linked molecular beacons for imaging mRNAs in the cytoplasm of living cells",
      "volume": "33",
      "author": "Mhlanga",
      "year": "2005",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B14",
      "doi-asserted-by": "crossref",
      "first-page": "17008",
      "DOI": "10.1073/pnas.0505580102",
      "article-title": "Mechanism of mRNA transport in the nucleus",
      "volume": "102",
      "author": "Vargas",
      "year": "2005",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B15",
      "doi-asserted-by": "crossref",
      "first-page": "682",
      "DOI": "10.1128/JVI.80.2.682-688.2006",
      "article-title": "Live-cell characterization and analysis of a clinical isolate of bovine respiratory syncytial virus, using molecular beacons",
      "volume": "80",
      "author": "Santangelo",
      "year": "2006",
      "journal-title": "J. Virol"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B16",
      "doi-asserted-by": "crossref",
      "first-page": "1909",
      "DOI": "10.1158/0008-5472.CAN-04-3196",
      "article-title": "Real-time detection of gene expression in cancer cells using molecular beacon imaging: new strategies for cancer research",
      "volume": "65",
      "author": "Peng",
      "year": "2005",
      "journal-title": "Cancer Res"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B17",
      "doi-asserted-by": "crossref",
      "first-page": "4713",
      "DOI": "10.1021/ac050881y",
      "article-title": "Simultaneous monitoring of the expression of multiple genes inside of single breast carcinoma cells",
      "volume": "77",
      "author": "Medley",
      "year": "2005",
      "journal-title": "Anal. Chem"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B18",
      "doi-asserted-by": "crossref",
      "first-page": "2041",
      "DOI": "10.1002/cbic.200500046",
      "article-title": "Stochasticity of manganese superoxide dismutase mRNA expression in breast carcinoma cells by molecular beacon imaging",
      "volume": "6",
      "author": "Drake",
      "year": "2005",
      "journal-title": "Chembiochem"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B19",
      "doi-asserted-by": "crossref",
      "first-page": "1049",
      "DOI": "10.1002/(SICI)1521-3773(20000317)39:6<1049::AID-ANIE1049>3.0.CO;2-2",
      "article-title": "Molecular beacons: a novel approach to detect protein - DNA interactions. This work was partially supported by a U.S. NSF Career Award (CHE-9733650) and by a U.S. Office of Naval Research Young Investigator Award (N00014-98-1-0621)",
      "volume": "39",
      "author": "Li",
      "year": "2000",
      "journal-title": "Angew. Chem. Int. Ed. Engl"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B20",
      "doi-asserted-by": "crossref",
      "first-page": "E52",
      "DOI": "10.1093/nar/28.11.e52",
      "article-title": "Using molecular beacons as a sensitive fluorescence assay for enzymatic cleavage of single-stranded DNA",
      "volume": "28",
      "author": "Li",
      "year": "2000",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B21",
      "doi-asserted-by": "crossref",
      "first-page": "E89",
      "DOI": "10.1093/nar/29.17.e89",
      "article-title": "Linear 2\u2032 O-Methyl RNA probes for the visualization of RNA in living cells",
      "volume": "29",
      "author": "Molenaar",
      "year": "2001",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B22",
      "doi-asserted-by": "crossref",
      "first-page": "165",
      "DOI": "10.1038/sj.onc.1201939",
      "article-title": "Involvement of Myc targets in c-myc and N-myc induced human tumors",
      "volume": "17",
      "author": "Ben-Yosef",
      "year": "1998",
      "journal-title": "Oncogene"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B23",
      "doi-asserted-by": "crossref",
      "first-page": "12705",
      "DOI": "10.1016/S0021-9258(18)37810-4",
      "article-title": "Transcriptional regulation of c-myc oncogene expression by estrogen in hormone-responsive human breast cancer cells",
      "volume": "263",
      "author": "Dubik",
      "year": "1988",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B24",
      "doi-asserted-by": "crossref",
      "first-page": "75",
      "DOI": "10.1002/path.1385",
      "article-title": "Association of C-MYC amplification with progression from the in situ to the invasive stage in C-MYC-amplified breast carcinomas",
      "volume": "201",
      "author": "Robanus-Maandag",
      "year": "2003",
      "journal-title": "J. Pathol"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B25",
      "doi-asserted-by": "crossref",
      "first-page": "151",
      "DOI": "10.1016/j.cancergencyto.2005.08.013",
      "article-title": "The MYC oncogene in breast cancer progression: from benign epithelium to invasive carcinoma",
      "volume": "165",
      "author": "Corzo",
      "year": "2006",
      "journal-title": "Cancer Genet. Cytogenet"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B26",
      "doi-asserted-by": "crossref",
      "first-page": "1612",
      "DOI": "10.1038/sj.bjc.6601703",
      "article-title": "Correlation of amplification and overexpression of the c-myc oncogene in high-grade breast cancer: FISH, in situ hybridisation and immunohistochemical analyses",
      "volume": "90",
      "author": "Blancato",
      "year": "2004",
      "journal-title": "Br. J. Cancer"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B27",
      "doi-asserted-by": "crossref",
      "first-page": "116",
      "DOI": "10.1016/j.mcp.2006.09.001",
      "article-title": "Optimized linkage and quenching strategies for quantum dot molecular beacons",
      "volume": "21",
      "author": "Cady",
      "year": "2007",
      "journal-title": "Mol. Cell. Probes"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B28",
      "doi-asserted-by": "crossref",
      "first-page": "2496",
      "DOI": "10.1073/pnas.83.8.2496",
      "article-title": "Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture",
      "volume": "83",
      "author": "Berthois",
      "year": "1986",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B29",
      "doi-asserted-by": "crossref",
      "first-page": "18",
      "DOI": "10.1158/0008-5472.18.65.1",
      "article-title": "The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer",
      "volume": "65",
      "author": "Chu",
      "year": "2005",
      "journal-title": "Cancer Res"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B30",
      "doi-asserted-by": "crossref",
      "first-page": "2911",
      "DOI": "10.1093/nar/15.7.2911",
      "article-title": "Rapid hybridization kinetics of DNA attached to submicron latex particles",
      "volume": "15",
      "author": "Wolf",
      "year": "1987",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B31",
      "doi-asserted-by": "crossref",
      "first-page": "204",
      "DOI": "10.1006/abio.1999.4344",
      "article-title": "Real-time measurements of DNA hybridization on microparticles with fluorescence resonance energy transfer",
      "volume": "276",
      "author": "Henry",
      "year": "1999",
      "journal-title": "Anal. Biochem"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B32",
      "doi-asserted-by": "crossref",
      "first-page": "26801",
      "DOI": "10.1016/S0021-9258(18)47090-1",
      "article-title": "Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding",
      "volume": "269",
      "author": "Brown",
      "year": "1994",
      "journal-title": "J. Biol. Chem"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B33",
      "doi-asserted-by": "crossref",
      "first-page": "3857",
      "DOI": "10.1093/nar/21.16.3857",
      "article-title": "Intracellular disposition and metabolism of fluorescently-labeled unmodified and modified oligonucleotides microinjected into mammalian cells",
      "volume": "21",
      "author": "Fisher",
      "year": "1993",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B34",
      "doi-asserted-by": "crossref",
      "first-page": "1239",
      "DOI": "10.1158/1535-7163.MCT-05-0046",
      "article-title": "Selenium disrupts estrogen receptor (alpha) signaling and potentiates tamoxifen antagonism in endometrial cancer cells and tamoxifen-resistant breast cancer cells",
      "volume": "4",
      "author": "Shah",
      "year": "2005",
      "journal-title": "Mol. Cancer Ther"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B35",
      "doi-asserted-by": "crossref",
      "first-page": "789",
      "DOI": "10.1002/ijc.11263",
      "article-title": "Additive effects of tamoxifen and the farnesyl transferase inhibitor FTI-277 on inhibition of MCF-7 breast cancer cell-cycle progression",
      "volume": "106",
      "author": "Doisneau-Sixou",
      "year": "2003",
      "journal-title": "Int. J. Cancer"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B36",
      "doi-asserted-by": "crossref",
      "first-page": "3866",
      "DOI": "10.1128/AEM.71.7.3866-3871.2005",
      "article-title": "An internal reference technique for accurately quantifying specific mRNAs by real-time PCR with application to the tceA reductive dehalogenase gene",
      "volume": "71",
      "author": "Johnson",
      "year": "2005",
      "journal-title": "Appl. Environ. Microbiol"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B37",
      "doi-asserted-by": "crossref",
      "first-page": "634",
      "DOI": "10.1373/clinchem.2005.048983",
      "article-title": "Quantification of mRNA in whole blood by assessing recovery of RNA and efficiency of cDNA synthesis",
      "volume": "52",
      "author": "Mitsuhashi",
      "year": "2006",
      "journal-title": "Clin. Chem"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B38",
      "doi-asserted-by": "crossref",
      "first-page": "70",
      "DOI": "10.1021/bc0497923",
      "article-title": "Noninvasive molecular imaging of MYC mRNA expression in human breast cancer xenografts with a [99mTc]peptide-peptide nucleic acid-peptide chimera",
      "volume": "16",
      "author": "Tian",
      "year": "2005",
      "journal-title": "Bioconjug. Chem"
    },
    {
      "key": "key\n\t\t\t\t20170720102446_B39",
      "doi-asserted-by": "crossref",
      "first-page": "106",
      "DOI": "10.1196/annals.1339.038",
      "article-title": "External imaging of CCND1, MYC, and KRAS oncogene mRNAs with tumor-targeted radionuclide-PNA-peptide chimeras",
      "volume": "1059",
      "author": "Tian",
      "year": "2005",
      "journal-title": "Ann. N.Y. Acad. Sci"
    }
  ],
  "container-title": "Nucleic Acids Research",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://academic.oup.com/nar/article-pdf/35/16/e105/18778356/gkm593.pdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        5,
        13
      ]
    ],
    "date-time": "2023-05-13T20:33:51Z",
    "timestamp": 1684010031000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkm593"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2007,
        8
      ]
    ]
  },
  "references-count": 39,
  "journal-issue": {
    "issue": "16",
    "published-online": {
      "date-parts": [
        [
          2007,
          8,
          15
        ]
      ]
    },
    "published-print": {
      "date-parts": [
        [
          2007,
          8
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1093/nar/gkm593",
  "relation": {},
  "ISSN": [
    "1362-4962",
    "0305-1048"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        2007,
        8
      ]
    ]
  }
}