Membrane and transmembrane signaling in Herpesvirus saimiri-transformed human CD4+ and CD8+ T lymphocytes is ATM-independent.
10.1093/intimm/12.6.927
Crossref journal-article
Oxford University Press (OUP)
International Immunology (286)
Bibliography

Rivero-Carmena, M., Porras, O., Pelaez, B., Pacheco-Castro, A., Gatti, R. A., & Regueiro, J. R. (2000). Membrane and transmembrane signaling in Herpesvirus saimiri-transformed human CD4+ and CD8+ T lymphocytes is ATM-independent. International Immunology, 12(6), 927–935.

Authors 6
  1. Miguel Rivero-Carmena (first)
  2. Oscar Porras (additional)
  3. Blondineth Pelaez (additional)
  4. Alberto Pacheco-Castro (additional)
  5. Richard A. Gatti (additional)
  6. José R. Regueiro (additional)
References 46 Referenced 13
  1. Gatti, R. A. 1998. Ataxia-Telangiectasia. In Vogelstein, B. and Kinzler, K. W., eds, The Genetic Basis of Human Cancer, p. 275. McGraw-Hill, New York. (10.1006/rwei.1999.0066)
  2. Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., Ashkenazi, M., Pecker, I., Frydman, M., Harnik, R., Patanjali, S. R., Simmons, A., Clines, G. A., Sartiel, A., Gatti, R. A., Chessa, L., Sanal, O., Lavin, M. F., Miki, T., Weissman, S. M., Lovett, M., Collins, F. S. and Shiloh Y. 1995. A single Ataxia-Telangiectasia gene with a product similar to PI-3 kinase. Science268:1749 (10.1126/science.7792600)
  3. Keith, C. T. and Schreiber S. L. 1995. PI3K-related kinases: DNA repair, recombination, and cell cycle checkpoints. Science270:50 (10.1126/science.270.5233.50)
  4. Zakian, V. A. 1995. ATM-related genes: what do they tell us about functions of the human gene? Cell82:685. (10.1016/0092-8674(95)90463-8)
  5. Lim, D. S., Kirsch, D. G., Canman, C. E., Ahn, J. H., Ziv, Y., Newman, L. S., Darnell, R.B., Shiloh, Y. and Kastan, M. B. 1998. ATM binds to beta-adaptin in cytoplasmic vesicles. Proc. Natl Acad. Sci. USA95:10146. (10.1073/pnas.95.17.10146)
  6. Barlow, C., Hirotsune, S., Paylor, R., Liyanage, M., Eckhaus, M., Collins, F., Shiloh, Y., Crawley, J. N., Ried, T., Tagle, D. and Wynshaw-Boris, A. 1996. Atm-deficient mice: a paradigm of ataxia-telangiectasia. Cell86:159. (10.1016/S0092-8674(00)80086-0)
  7. Kondo, N., Inoue, R., Nishimura, S., Kasahara, K., Kameyama, T., Miwa, Y., R. Lorenzo P.R. and Orii, T. 1993. Defective calcium-dependent signal transduction in T lymphocytes of ataxia-telangiectasia. Scand. J. Immunol.38:45. (10.1111/j.1365-3083.1993.tb01692.x)
  8. O'Connor, R. D. and Scott-Linthicum, D. 1980. Mitogen receptor redistribution defects and concomitant absence of blastogenesis in ataxia-telangiectasia T lymphocytes. Clin. Immun. Immunopathol.15:66. (10.1016/0090-1229(80)90021-5)
  9. Khanna, K. K., Yan, J., Watters, D., Hobson, K., Beamish, H., Spring, K., Shiloh, Y., Gatti, R. A. and Lavin, M. F. 1997. Defective signaling through the B cell antigen receptor in Epstein–Barr virus-transformed Ataxia-Telangiectasia cells. J. Biol. Chem.272:9489. (10.1074/jbc.272.14.9489)
  10. Lavin, M.F. and Shiloh,Y. 1997. The genetic defect in Ataxia-Telangiectasia. Annu. Rev. Immunol.15:177. (10.1146/annurev.immunol.15.1.177)
  11. Biesinger, B., Müller-Fleckenstein, I. and Simmer, B. 1992. Stable growth transformation of human T lymphocytes by Herpesvirus saimiri. Proc. Natl Acad. Sci. USA89:3116. (10.1073/pnas.89.7.3116)
  12. Mittrücker, H. W., Müller-Fleckenstein, I., Fleckenstein, B. and Fleischer, B. 1992. CD2-mediated autocrine growth of Herpesvirus saimiri-transformed human T lymphocytes. J. Exp. Med.176:909. (10.1084/jem.176.3.909)
  13. Mittrücker, H. W., Müller-Fleckenstein, I., Fleckenstein, B. and Fleischer, B. 1993. Herpesvirus saimiri-transformed human T lymphocytes: normal functional phenotype and preserved T cell receptor signalling. Int. Immunol.5:985. (10.1093/intimm/5.8.985)
  14. De Carli, M., Berthold, S., Fickenscher, H., Müller-Fleckenstein, I., D'Elios, M. M., Gao, Q., Biagiotti, R., Giudizi, M. G., Kalden, J. R., Fleckenstein, B., Romagnani, S. and Del Prete, G. 1993. Immortalization with Herpesvirus saimiri modulates the cytokine secretion profile of established Th1 and Th2 human T cell clones. J. Immunol.151:5022. (10.4049/jimmunol.151.9.5022)
  15. Kraft, M. S., Henning, G., Fickenscher, H., Lengenfelder, D., Tschopp, J., Fleckenstein, B. and Meinl, E. 1998. Herpesvirus saimiri transforms human T-cell clones to stable growth without inducing resistance to apoptosis. J. Virol.72:3138. (10.1128/JVI.72.4.3138-3145.1998)
  16. Alvarez-Zapata, D., de Miguel-Olalla, S., Fontán, G., Ferreira, A., García-Rodriguez, M. C., Madero, L., van den Elsen, P. and Regueiro, J. R. 1997. Phenotypical and functional characterization of Herpesvirus saimiri-immortalized human major histocompatibility complex class II-deficient T lymphocytes. Tissue Antigens.51:250. (10.1111/j.1399-0039.1998.tb03099.x)
  17. Pacheco-Castro, A., Alvarez-Zapata, D., Serrano, P. and Regueiro, J. R. 1998. Signaling through a CD3 gamma-deficient TCR/CD3 complex in immortalized mature CD4+ and CD8+ T lymphocytes. J. Immunol.161:3152. (10.1016/S0161-5890(98)90395-9)
  18. Cabanillas, J. A., García, M. C., Cambronero, R., Fontán, G., Pacheco, A., Ferreira, A. and Regueiro, J. R. 1998. Herpesvirus saimiri-immortalized T cells from patients with Common variable immunodeficiency. Inmunología17:93.
  19. Bröker, B. M., Kraft, M. S., Klauenberg, U., Le Deist, F., de Villartay, J. P., Fleckenstein, B., Fleischer, B. and Meinl, E. 1997. Activation induces apoptosis in Herpesvirus saimiri-transformed T cells independent of CD95 (Fas, APO-1). Eur. J. Immunol.27:2774. (10.1002/eji.1830271105)
  20. Stephan, V., Wahn, V., Le Deist, F., Dirksen, U., Bröker, B., Müller-Fleckenstein, I., Horneff, G., Schroten, H., Fischer, A. and de Saint Basile, G. 1996. Atypical X-linked severe combined immunodeficiency due to possible spontaneous reversion of the genetic defect in T cells. N. Engl. J. Med.335:1563. (10.1056/NEJM199611213352104)
  21. Gallego, M. D., Santamaría, M., Peña, J. and Molina, I. J. 1997. Defective actin reorganization and polymerization of Wiskott–Aldrich T cells in response to CD3-mediated stimulation. Blood90:3089. (10.1016/S0165-2478(97)85170-X)
  22. Uhrhammer, N., Lange, E., Porras, O., Naeim, A., Chen, X., Sheikhavandi, S., Chiplunkar, S., Yang, L., Dandekar, S., Liang, T., Patel, N., Teraoka, S., Udar, N., Calvo, N., Concannon, P., Lange, K. and Gatti, R. A. 1995. Sublocalization of an ataxia-telangiectasia gene distal to D11S384 by ancestral haplotyping in Costa Rican families. Am. J. Hum. Genet.57:103.
  23. Telatar, M., Castellvi-Bel, S., Tai, L., Wang, Z., Sheikhavandi, S., Rivero-Carmena, M., Regueiro, J. R., Porras, O. and Gatti, R. A. 1998. A model for ATM heterozygote identification in a large population: four founder effect ATM mutations identify most of Costa Rican patients with ataxia-telangiectasia. Mol. Genet. Metab.64:36. (10.1006/mgme.1998.2693)
  24. Assenmacher, M., Schmitz, J. and Radbruch, A. 1994. Flow cytometric determination of cytokines in activated murine T helper lymphocytes: expression of interleukin-10 in interferon-gamma and in interleukin-4-expressing cell. Eur. J. Immunol.24:1097. (10.1002/eji.1830240513)
  25. Gallart, T., de la Fuente, M. A., Barceló, J., Alberola-Ila, J. and Lozano, F. 1997. Desialylation of T lymphocytes overcomes the monocyte dependency of pokeweed mitogen-induced T-cell activation. Immunology90:57. (10.1046/j.1365-2567.1997.00129.x)
  26. Gorski, A., Grieb, P., Korczak-Kowalska, G., Wierzbicki, P., Stepien-Sopniewska, B. and Mrowiec, T. 1993. Cladribine (2-chloro-deoxyadenosine, CDA): an inhibitor of human B and T cell activation in vitro. Immunopharmacology26:197.
  27. Fickenscher, H., Biesinger, B., Knappe, A., Wittmann, S. and Fleckestein, B. 1996. Regulation of the Herpesvirus saimiri oncogene StpC, similar to that of T cell activation genes,in growth-transformed human T lymphocytes. J. Virol.70:6012.
  28. Biesinger, B., Tsygankov, A. Y., Fickenscher, H., Emmrich, F., Fleckestein, B., Bolen, J. and Bröker, B. 1995. The product of Herpesvirus saimiri oncogene open reading frame 1 (Tip1) interacts with the T cell-specific tyrosine kinase p56lck in transformed cells. J. Biol. Chem.270:4729. (10.1074/jbc.270.9.4729)
  29. Regueiro, J. R., Rodríguez-Gallego, C. and Arnaiz-Villena, A. 1994. Other primary T cell defects. In Regueiro, J. R., Rodríguez-Gallego, C. and Arnaiz-Villena, A., eds, Human T Lymphocyte Activation Deficiencies, p. 35. Landes, Austin, TX.
  30. McFarlin, D. E., Strober, W. and Waldmann, T. A. 1972. Ataxia-telangiectasia. Medicine51:281. (10.1097/00005792-197207000-00002)
  31. Aguilar, M. J., Kamoshita, S., Landing, B. H., Boder, E. and Sedgwick, R. P. 1968. Pathological observations in ataxia-telangiectasia. A report of five cases. J. Neuropathol. Exp. Neurol.27:659. (10.1097/00005072-196810000-00009)
  32. Peterson, R. D., Kelly, W. D. and Good, R. A. 1964. Ataxia-telangiectasia: its association with a defective thymus, immunological-deficiency disease, and malignancy. Lanceti:1189. (10.1016/S0140-6736(64)91209-7)
  33. Gatti, R. A., Bick, M. B., Tam, C. F., Medici, M. A., Oxelius, V. A., Holland, M., Goldstein, A. L. and Boder, E. 1982. Ataxia-telangiectasia: a multiparameter analysis of eight families. Clin. Immunol. Immunopathol.23:501. (10.1016/0090-1229(82)90134-9)
  34. Paganelli, R., Scalla, E., Scarselli, E., Ortolani, C., Cossarizza, A., Carmini, D., Aiuti, F. and Fiorilli, M. 1992. Selective deficiency of CD4+/CD45RA+ lymphocytes in patients with ataxia-telangiectasia. J. Clin. Immunol.12:84. (10.1007/BF00918137)
  35. Mackall, C. L., Granger, M.A., Sheard, R., Cepeda, R. and Gress, R. E. 1993. T-cell regeneration after bone marrow transplantation: differential CD45 isoform expression on thymic-derived versus thymic-independent progeny. Blood82:2585. (10.1182/blood.V82.8.2585.2585)
  36. Kuljis, R. O., Xu, Y., Aguila, M. C. and Baltimore, D. 1997. Degeneration of neurons, synapses, and neutrophil and glial activation in a murine atm knockout model of ataxia-telangiectasia. Proc. Natl Acad. Sci. USA94:12688. (10.1073/pnas.94.23.12688)
  37. Lahat, N., Zelnik, N., Froom, P., Kinarty, A. and Etzioni, A. 1988. Impaired autologous mixed lymphocyte reaction (AMLR) in patients with ataxia-telangiectasia and their family members. Clin. Exp. Immunol.74:32.
  38. Paganelli, R., Capobianchi, M. R., Matricardi, P. M., Cioe, L., Seminara, R., Dianzani, F. and Aiuti, F. 1984. Defective interferon-gamma production in ataxia-telangiectasia. Clin. Immunol. Immunopathol.32:387. (10.1016/0090-1229(84)90282-4)
  39. Waldmann, T. A. 1982. Immunological abnormalities in ataxia-telangiectasia. In Bridges, B. A. and Harnden, D. G., eds, Ataxia-telangiectasia: A Cellular and Molecular Link between Cancer, Neuropathology and Immune Deficiency, p. 37. New York, Wiley.
  40. Levis, W. R., Dattner, A. M. and Shaw, J. S. 1978. Selective defects in T cell functions in Ataxia-Telangiectasia. Clin. Exp. Immunol.37:44.
  41. Watters, D., Khanna, K. K., Beamish, H., Birrel, G., Spring, K., Kedar, P., Gatei, M., Stenzel, D., Hobson, K., Kozlov, S., Zhang, N., Farrell, A., Ramsay, J., Gatti, R. and Lavin, F. 1997. Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms. Oncogene14:1911. (10.1038/sj.onc.1201037)
  42. Hartley, D. A., Hurley, T. R., Hardwick, J. S., Lund, T. C., Medveczky, P. G. and Sefton, B. M. 1999. Activation of the lck tyrosine-protein kinase by the binding of the Tip protein of Herpesvirus saimiri in the absence of regulatory tyrosine phosphorylation. J. Biol. Chem.274:20056. (10.1074/jbc.274.29.20056)
  43. Yachnin, S. 1976. Demonstration of the inhibitory effect of human alpha-fetoprotein on in vitro transformation of human lymphocytes. Proc. Natl Acad. Sci. USA73:2857. (10.1073/pnas.73.8.2857)
  44. Chao, C., Yang, E. M., and Xu, Y. 2000. Rescue of defective T cell development and function in ATM–/– mice by a functional TCRαβ transgene. J. Immunol.164:345 (10.4049/jimmunol.164.1.345)
  45. Fruehling, S. and Longnecker, R. 1997. The immunoreceptor tyrosine-based activation motif of Epstein–Barr virus LMP2A is essential for blocking BCR-mediated signal transduction. Virology.235:241. (10.1006/viro.1997.8690)
  46. Xu, Y., Ashley, T., Brainerd, E. E., Bronson, R. T., Meyn, M. S. and Baltimore, D. 1996. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev.10:2411. (10.1101/gad.10.19.2411)
Dates
Type When
Created 23 years, 1 month ago (July 26, 2002, 6:23 p.m.)
Deposited 2 years, 4 months ago (April 22, 2023, 11:33 p.m.)
Indexed 2 months ago (June 30, 2025, 7:26 a.m.)
Issued 25 years, 3 months ago (June 1, 2000)
Published 25 years, 3 months ago (June 1, 2000)
Published Online 25 years, 3 months ago (June 1, 2000)
Published Print 25 years, 3 months ago (June 1, 2000)
Funders 0

None

@article{Rivero_Carmena_2000, title={Membrane and transmembrane signaling in Herpesvirus saimiri-transformed human CD4+ and CD8+ T lymphocytes is ATM-independent.}, volume={12}, ISSN={0953-8178}, url={http://dx.doi.org/10.1093/intimm/12.6.927}, DOI={10.1093/intimm/12.6.927}, number={6}, journal={International Immunology}, publisher={Oxford University Press (OUP)}, author={Rivero-Carmena, Miguel and Porras, Oscar and Pelaez, Blondineth and Pacheco-Castro, Alberto and Gatti, Richard A. and Regueiro, José R.}, year={2000}, month=jun, pages={927–935} }