DOI: 10.1093/infdis/jir045. Type II Secretion System of Pseudomonas aeruginosa: In Vivo Evidence of a Significant Role in Death Due to Lung Infection

Type II Secretion System of Pseudomonas aeruginosa: In Vivo Evidence of a Significant Role in Death Due to Lung Infection

10.1093/infdis/jir045

Crossref journal-article

Oxford University Press (OUP)

The Journal of Infectious Diseases (286)

Bibliography

Jyot, J., Balloy, V., Jouvion, G., Verma, A., Touqui, L., Huerre, M., Chignard, M., & Ramphal, R. (2011). Type II Secretion System of Pseudomonas aeruginosa: In Vivo Evidence of a Significant Role in Death Due to Lung Infection. The Journal of Infectious Diseases, 203(10), 1369â1377.

Authors 8

Jeevan Jyot (first)
Viviane Balloy (additional)
Gregory Jouvion (additional)
Amrisha Verma (additional)
Lhousseine Touqui (additional)
Michel Huerre (additional)
Michel Chignard (additional)
Reuben Ramphal (additional)

References 39 Referenced 73

10.1378/chest.109.4.1019 / Chest / Ventilator-associated pneumonia due to Pseudomonas aeruginosa by Couch-Brewer (1996)
{'key': 'key\n\t\t\t\t20170702143923_bib2', 'first-page': 'L551', 'article-title': 'Exoproduct secretions of Pseudomonas aeruginosa strains influence severity of alveolar epithelial injury', 'volume': '267', 'author': 'Kudoh', 'year': '1994', 'journal-title': 'Am J Physiol'} / Am J Physiol / Exoproduct secretions of Pseudomonas aeruginosa strains influence severity of alveolar epithelial injury by Kudoh (1994)
10.1128/IAI.70.3.1352-1358.2002 / Infect Immun / Pulmonary inflammation induced by Pseudomonas aeruginosa lipopolysaccharide, phospholipase C, and exotoxin A: role of interferon regulatory factor 1 by Wieland (2002)
10.1016/j.tim.2005.09.005 / Trends Microbiol / Type II secretion: a protein secretion system for all seasons by Cianciotto (2005)
10.1016/j.mib.2008.12.007 / Curr Opin Microbiol / Role of Pseudomonas aeruginosa type III effectors in disease by Engel (2009)
10.1074/jbc.M508089200 / J Biol Chem / The PscE-PscF-PscG complex controls type III secretion needle biogenesis in Pseudomonas aeruginosa by Quinaud (2005)
10.1046/j.1365-2958.2002.02759.x / Mol Microbiol / A novel type II secretion system in Pseudomonas aeruginosa by Ball (2002)
10.1046/j.1365-2958.1998.00888.x / Mol Microbiol / Identification of an additional member of the secretin superfamily of proteins in Pseudomonas aeruginosa that is able to function in type II protein secretion by Martínez (1998)
10.1128/IAI.72.12.6969-6977.2004 / Infect Immun / Relative contributions of Pseudomonas aeruginosa ExoU, ExoS, and ExoT to virulence in the lung by Shaver (2004)
10.1086/320737 / J Infect Dis / Type III protein secretion is associated with death in lower respiratory and systemic Pseudomonas aeruginosa infections by Roy-Burman (2001)
10.1016/0378-1135(87)90090-3 / Vet Microbiol / Assessment of elastase as a Pseudomonas aeruginosa virulence factor in experimental lung infection in mink by Elsheikh (1987)
10.1128/IAI.39.1.198-201.1983 / Infect Immun / Evaluation of Pseudomonas aeruginosa exotoxin A and elastase as virulence factors in acute lung infection by Blackwood (1983)
10.1128/IAI.57.5.1369-1373.1989 / Infect Immun / Mutations in the hemolytic-phospholipase C operon result in decreased virulence of Pseudomonas aeruginosa PAO1 grown under phosphate-limiting conditions by Ostroff (1989)
10.4049/jimmunol.181.1.586 / J Immunol / Control of Pseudomonas aeruginosa in the lung requires the recognition of either lipopolysaccharide or flagellin by Ramphal (2008)
10.4049/jimmunol.175.6.3927 / J Immunol / TLRs 2 and 4 are not involved in hypersusceptibility to acute Pseudomonas aeruginosa lung infections by Ramphal (2005)
10.1016/S1534-5807(03)00019-4 / Dev Cell / Coordinate regulation of bacterial virulence genes by a novel adenylate cyclase-dependent signaling pathway by Wolfgang (2003)
10.1128/IAI.73.3.1695-1705.2005 / Infect Immun / Activities of Pseudomonas aeruginosa effectors secreted by the type III secretion system in vitro and during infection by Lee (2005)
10.1046/j.1365-2958.2003.03740.x / Mol Microbiol / A four-tiered transcriptional regulatory circuit controls flagellar biogenesis in Pseudomonas aeruginosa by Dasgupta (2003)
10.1016/S0378-1119(98)00130-9 / Gene / A broad-host range Flp-FRT recombination system for site-specific excision of chromosomally located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutants by Hoang (1998)
10.1111/j.1365-2958.1989.tb01816.x / Mol Microbiol / Cloning of xcp genes located at the 55 min region of the chromosome and involved in protein secretion in Pseudomonas aeruginosa by Filloux (1989)
10.1006/plas.1999.1441 / Plasmid / Integration-proficient plasmids for Pseudomonas aeruginosa: site-specific integration and use for engineering of reporter and expression strains by Hoang (2000)
10.1007/s00203-003-0541-8 / Arch Microbiol / Secretins of Pseudomonas aeruginosa: large holes in the outer membrane by Bitter (2003)
10.4049/jimmunol.162.1.392 / J Immunol / IL-10 is a major mediator of sepsis-induced impairment in lung antibacterial host defense by Steinhauser (1999)
10.1128/IAI.01213-09 / Infect Immun / Characterization and modulation of the immunosuppressive phase of sepsis by Muenzer (2010)
10.4049/jimmunol.180.9.5771 / J Immunol / IL-10: the master regulator of immunity to infection by Couper (2008)
10.1128/JB.185.7.2080-2095.2003 / J Bacteriol / Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment by Wagner (2003)
10.1111/j.1574-6968.1992.tb05824.x / FEMS Microbiol Rev / Protein secretion in Pseudomonas aeruginosa by Tommassen (1992)
10.1128/IAI.67.11.6164-6167.1999 / Infect Immun / Cell death of human polymorphonuclear neutrophils induced by a Pseudomonas aeruginosa cystic fibrosis isolate requires a functional type III secretion system by Dacheux (1999)
10.1111/j.1574-695X.1996.tb00084.x / FEMS Immunol Med Microbiol / Interleukin-10 inhibits neutrophil phagocytic and bactericidal activity by Laichalk (1996)
10.1073/pnas.89.18.8676 / Proc Natl Acad Sci U S A / Interleukin 10 inhibits macrophage microbicidal activity by blocking endogenous production of tumor necrosis factor-α required as a costimulatory factor for interferon-γ-induced activation by Oswald (1992)
10.1139/m82-102 / Can J Microbiol / Interaction of Pseudomonas exoproducts with phagocytic cells by Weber (1982)
10.1128/IAI.67.5.2371-2376.1999 / Infect Immun / Pseudomonas aeruginosa hemolytic phospholipase C suppresses neutrophil respiratory burst activity by Terada (1999)
10.1099/0022-1317-50-9-822 / J Med Microbiol / Impairment of host defence by exotoxin A in Pseudomonas aeruginosa pneumonia in mice by Schultz (2001)
10.1128/IAI.34.1.147-153.1981 / Infect Immun / Production of exoenzyme S by clinical isolates of Pseudomonas aeruginosa by Sokol (1981)
10.1097/00003246-200203000-00005 / Crit Care Med / Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa by Hauser (2002)
10.1086/379372 / J Infect Dis / Secretion of the toxin ExoU is a marker for highly virulent Pseudomonas aeruginosa isolates obtained from patients with hospital-acquired pneumonia by Schulert (2003)
10.1038/7391 / Nat Med / Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury by Sawa (1999)
10.1093/infdis/128.4.506 / J Infect Dis / Exotoxins of Pseudomonas aeruginosa. I. Factors that influence the production of exotoxin A by Liu (1973)
10.4049/jimmunol.0801497 / J Immunol / Lack of MyD88 protects the immunodeficient host against fatal lung inflammation triggered by the opportunistic bacteria Burkholderia cenocepacia by Ventura (2009)

Dates

Type	When
Created	14 years, 4 months ago (April 16, 2011, 3:45 a.m.)
Deposited	2 years, 2 months ago (June 6, 2023, 6:24 a.m.)
Indexed	1 month ago (July 27, 2025, 3:16 a.m.)
Issued	14 years, 3 months ago (May 15, 2011)
Published	14 years, 3 months ago (May 15, 2011)
Published Online	14 years, 3 months ago (May 15, 2011)
Published Print	14 years, 3 months ago (May 15, 2011)

Funders 0

None

BibTeX

@article{Jyot_2011, title={Type II Secretion System of Pseudomonas aeruginosa: In Vivo Evidence of a Significant Role in Death Due to Lung Infection}, volume={203}, ISSN={0022-1899}, url={http://dx.doi.org/10.1093/infdis/jir045}, DOI={10.1093/infdis/jir045}, number={10}, journal={The Journal of Infectious Diseases}, publisher={Oxford University Press (OUP)}, author={Jyot, Jeevan and Balloy, Viviane and Jouvion, Gregory and Verma, Amrisha and Touqui, Lhousseine and Huerre, Michel and Chignard, Michel and Ramphal, Reuben}, year={2011}, month=may, pages={1369–1377} }

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      "volume": "89",
      "author": "Oswald",
      "year": "1992",
      "journal-title": "Proc Natl Acad Sci U S A"
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      "article-title": "Interaction of Pseudomonas exoproducts with phagocytic cells",
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      "author": "Weber",
      "year": "1982",
      "journal-title": "Can J Microbiol"
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      "article-title": "Pseudomonas aeruginosa hemolytic phospholipase C suppresses neutrophil respiratory burst activity",
      "volume": "67",
      "author": "Terada",
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      "article-title": "Impairment of host defence by exotoxin A in Pseudomonas aeruginosa pneumonia in mice",
      "volume": "50",
      "author": "Schultz",
      "year": "2001",
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      "article-title": "Production of exoenzyme S by clinical isolates of Pseudomonas aeruginosa",
      "volume": "34",
      "author": "Sokol",
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      "volume": "30",
      "author": "Hauser",
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      "journal-title": "Crit Care Med"
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      "DOI": "10.1086/379372",
      "article-title": "Secretion of the toxin ExoU is a marker for highly virulent Pseudomonas aeruginosa isolates obtained from patients with hospital-acquired pneumonia",
      "volume": "188",
      "author": "Schulert",
      "year": "2003",
      "journal-title": "J Infect Dis"
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      "article-title": "Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury",
      "volume": "5",
      "author": "Sawa",
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      "article-title": "Exotoxins of Pseudomonas aeruginosa. I. Factors that influence the production of exotoxin A",
      "volume": "128",
      "author": "Liu",
      "year": "1973",
      "journal-title": "J Infect Dis"
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      "article-title": "Lack of MyD88 protects the immunodeficient host against fatal lung inflammation triggered by the opportunistic bacteria Burkholderia cenocepacia",
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