Crossref journal-article
Oxford University Press (OUP)
Human Molecular Genetics (286)
Bibliography

Gegg, M. E., Cooper, J. M., Chau, K.-Y., Rojo, M., Schapira, A. H. V., & Taanman, J.-W. (2010). Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. Human Molecular Genetics, 19(24), 4861–4870.

Authors 6
  1. Matthew E. Gegg (first)
  2. J. Mark Cooper (additional)
  3. Kai-Yin Chau (additional)
  4. Manuel Rojo (additional)
  5. Anthony H.V. Schapira (additional)
  6. Jan-Willem Taanman (additional)
References 61 Referenced 774
  1. 10.1038/nrneurol.2010.52 / Nat. Rev. Neurol. / Molecular and clinical prodrome of Parkinson disease: implications for treatment by Schapira (2010)
  2. 10.1002/mds.22718 / Mov. Disord. / Protein degradation, aggregation, and misfolding by Cuervo (2010)
  3. 10.1016/S0140-6736(89)92366-0 / Lancet / Mitochondrial complex I deficiency in Parkinson's disease by Schapira (1989)
  4. 10.1016/S1474-4422(07)70327-7 / Lancet Neurol. / Mitochondria in the aetiology and pathogenesis of Parkinson's disease by Schapira (2008)
  5. 10.1038/81834 / Nat. Neurosci. / Chronic systemic pesticide exposure reproduces features of Parkinson's disease by Betarbet (2000)
  6. 10.1038/ng1769 / Nat. Genet. / High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease by Bender (2006)
  7. 10.4161/auto.1.1.1513 / Autophagy / Autophagy and its possible roles in nervous system diseases, damage and repair by Rubinsztein (2005)
  8. 10.1093/brain/awm318 / Brain / The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease by Pan (2008)
  9. 10.1038/nrn1868 / Nat. Rev. Neurosci. / Expanding insights of mitochondrial dysfunction in Parkinson's disease by Abou-Sleiman (2006)
  10. 10.1126/science.1096284 / Science / Hereditary early-onset Parkinson's disease caused by mutations in PINK1 by Valente (2004)
  11. 10.1038/77060 / Nat. Genet. / Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase by Shimura (2000)
  12. 10.1038/ng1884 / Nat. Genet. / Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase by Ramirez (2006)
  13. 10.1371/journal.pone.0004756 / PLoS ONE / Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells by Gegg (2009)
  14. 10.1016/j.expneurol.2009.05.027 / Exp. Neurol. / Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology by Grünewald (2009)
  15. 10.1016/j.nbd.2006.10.007 / Neurobiol. Dis. / Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6 by Hoepken (2006)
  16. 10.1371/journal.pone.0002455 / PLoS ONE / PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons by Wood-Kaczmar (2008)
  17. 10.1016/j.molcel.2009.02.013 / Mol. Cell. / PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death by Gandhi (2009)
  18. 10.1111/j.1471-4159.2009.05932.x / J. Neurochem. / Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux by Marongiu (2009)
  19. 10.1016/j.nbd.2007.07.010 / Neurobiol. Dis. / PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c by Wang (2007)
  20. 10.1073/pnas.0802076105 / Proc. Natl Acad. Sci. USA / Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress by Gautier (2008)
  21. 10.1073/pnas.0702717104 / Proc. Natl Acad. Sci. USA / Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice by Kitada (2007)
  22. 10.1371/journal.pone.0005777 / PLoS ONE / Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration by Gispert (2009)
  23. 10.1038/nature04788 / Nature / Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin by Park (2006)
  24. 10.1038/nature04779 / Nature / Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin by Clark (2006)
  25. 10.1073/pnas.0709336105 / Proc. Natl Acad. Sci. USA / The PINK1/Parkin pathway regulates mitochondrial morphology by Poole (2008)
  26. 10.1073/pnas.0711845105 / Proc. Natl Acad. Sci. USA / Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery by Yang (2008)
  27. 10.1523/JNEUROSCI.0719-07.2007 / J. Neurosci. / Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin by Exner (2007)
  28. 10.1074/jbc.M808515200 / J. Biol. Chem. / Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission by Dagda (2009)
  29. 10.1074/jbc.M109.035774 / J. Biol. Chem. / Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation by Lutz (2009)
  30. 10.1371/journal.pone.0005701 / PLoS ONE / Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1 by Sandebring (2009)
  31. 10.1093/hmg/ddp501 / Hum. Mol. Genet. / Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling by Sha (2010)
  32. 10.1016/j.bbrc.2009.04.006 / Biochem. Biophys. Res. Commun. / Parkin stabilizes PINK1 through direct interaction by Shiba (2009)
  33. 10.1083/jcb.200809125 / J. Cell Biol. / Parkin is recruited selectively to impaired mitochondria and promotes their autophagy by Narendra (2008)
  34. 10.1073/pnas.0911187107 / Proc. Natl Acad. Sci. USA / PINK1-dependent recruitment of Parkin to mitochondria in mitophagy by Vives-Bauza (2010)
  35. 10.1038/ncb2012 / Nat. Cell Biol. / PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1 by Geisler (2010)
  36. 10.1073/pnas.0913485107 / Proc. Natl Acad. Sci. USA / Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin by Ziviani (2010)
  37. 10.1038/sj.emboj.7601963 / EMBO J. / Fission and selective fusion govern mitochondrial segregation and elimination by autophagy by Twig (2008)
  38. 10.4161/auto.5338 / Autophagy / Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes by Klionsky (2008)
  39. 10.1016/j.yjmcc.2003.10.015 / J. Mol. Cell. Cardiol. / Metabolic dysfunction and depletion of mitochondria in hearts of septic rats by Watts (2004)
  40. 10.1016/j.mito.2007.02.001 / Mitochondrion / Inhibition of mitochondrial complex IV leads to secondary loss complex II–III activity: implications for the pathogenesis and treatment of mitochondrial encephalomyopathies by Hargreaves (2007)
  41. 10.1042/bj3050817 / Biochem. J. / Respiratory-deficient human fibroblasts exhibiting defective mitochondrial DNA replication by Bodnar (1995)
  42. 10.1016/j.bbamcr.2009.03.002 / Biochim. Biophys. Acta / Mitophagy by Tolkovsky (2009)
  43. 10.1016/j.semcdb.2010.01.002 / Semin. Cell Dev. Biol. / Mitochondrial fusion proteins: dual regulators of morphology and metabolism by Zorzano (2010)
  44. 10.1038/sj.emboj.7601249 / EMBO J / A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics by Yonashiro (2006)
  45. 10.1083/jcb.200910140 / J. Cell Biol. / PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy by Matsuda (2010)
  46. 10.1083/jcb.201001039 / J. Cell Biol. / Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy by Lee (2010)
  47. 10.1371/journal.pone.0010054 / PLoS ONE / The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway by Poole (2010)
  48. 10.1111/j.1365-2958.2008.06502.x / Mol. Microbiol. / Ubiquitin-dependent and -independent mitochondrial protein quality controls: implications in ageing and neurodegenerative diseases by Germain (2008)
  49. 10.1016/j.molcel.2009.04.026 / Mol. Cell / A role for ubiquitin in selective autophagy by Kirkin (2009)
  50. 10.1042/BST0380144 / Biochem. Soc. Trans. / Parkin-mediated ubiquitin signalling in aggresome formation and autophagy by Chin (2010)
  51. 10.1007/s10863-009-9253-3 / J. Bioenerg. Biomembr. / The PINK1/Parkin pathway: a mitochondrial quality control system? by Whitworth (2009)
  52. 10.4161/auto.6.5.12242 / Autophagy / How could Parkin-mediated ubiquitination of mitofusin promote mitophagy by Ziviani (2010)
  53. 10.1091/mbc.E08-02-0227 / Mol. Biol. Cell / Ubiquitin–proteasome-dependent degradation of a mitofusin, a critical regulator of mitochondrial fusion by Cohen (2008)
  54. 10.1134/S000629790913001X / Biochemistry (Mosc.) / Proteasome system of protein degradation and processing by Sorokin (2009)
  55. 10.1016/j.cell.2010.04.009 / Cell / Mitochondria supply membranes for autophagosome biogenesis during starvation by Hailey (2010)
  56. 10.1523/JNEUROSCI.6248-09.2010 / J. Neurosci. / Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex by Misko (2010)
  57. 10.1038/cdd.2009.200 / Cell Death Differ. / The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy by Michiorri (2010)
  58. 10.1001/archneurol.2010.198 / Arch. Neurol. / Chaperone-mediated autophagy markers are abnormal in Parkinson's disease brain by Alvarez-Erviti (2010)
  59. 10.1042/bj1540423 / Biochem. J. / Preparation and properties of mitochondria derived from synaptosomes by Lai (1976)
  60. 10.1002/jcp.20753 / J. Cell Physiol. / Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1 by Yoon (2006)
  61. 10.1242/jcs.115.8.1663 / J. Cell Sci. / Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo by Rojo (2002)
Dates
Type When
Created 14 years, 11 months ago (Sept. 25, 2010, 8:13 p.m.)
Deposited 3 years, 9 months ago (Nov. 10, 2021, 12:55 p.m.)
Indexed 3 hours, 14 minutes ago (Aug. 31, 2025, 6:01 a.m.)
Issued 14 years, 11 months ago (Sept. 24, 2010)
Published 14 years, 11 months ago (Sept. 24, 2010)
Published Online 14 years, 11 months ago (Sept. 24, 2010)
Published Print 14 years, 8 months ago (Dec. 15, 2010)
Funders 0

None

@article{Gegg_2010, title={Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy}, volume={19}, ISSN={0964-6906}, url={http://dx.doi.org/10.1093/hmg/ddq419}, DOI={10.1093/hmg/ddq419}, number={24}, journal={Human Molecular Genetics}, publisher={Oxford University Press (OUP)}, author={Gegg, Matthew E. and Cooper, J. Mark and Chau, Kai-Yin and Rojo, Manuel and Schapira, Anthony H.V. and Taanman, Jan-Willem}, year={2010}, month=sep, pages={4861–4870} }