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Vacher, C., Garcia-Oroz, L., & Rubinsztein, D. C. (2005). Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington’s disease. Human Molecular Genetics, 14(22), 3425–3433.

Authors 3
  1. Coralie Vacher (first)
  2. Lourdes Garcia-Oroz (additional)
  3. David C. Rubinsztein (additional)
References 35 Referenced 135
  1. Rubinsztein, D.C. (2003) How does the Huntington's disease mutation damage cells? Sci. Aging Knowledge Environ., 37, PE26. (10.1126/sageke.2003.37.pe26)
  2. DiFiglia, M., Sapp, E., Chase, K.O., Davies, S.W., Bates, G.P., Vonsattel, J.P. and Aronin, N. (1997) Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science, 277, 1990–1993. (10.1126/science.277.5334.1990)
  3. Taylor, J.P., Hardy, J. and Fischbeck, K.H. (2002) Toxic proteins in neurodegenerative disease. Science, 296, 1991–1995. (10.1126/science.1067122)
  4. Klement, I.A., Skinner, P.J., Kaytor, M.D., Yi, H., Hersch, S.M., Clark, H.B., Zoghbi, H.Y. and Orr, H.T. (1998) Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice. Cell, 95, 41–53. (10.1016/S0092-8674(00)81781-X)
  5. Tompkins, M.M., Basgall, E.J., Zamrini, E. and Hill, W.D. (1997) Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons. Am. J. Pathol., 150, 119–131.
  6. Arrasate, M., Mitra, S., Schweitzer, E.S., Segal, M.R. and Finkbeiner, S. (2004) Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature, 431, 805–810. (10.1038/nature02998)
  7. Caughey, B. and Lansbury, P.T. (2003) Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. Annu. Rev. Neurosci., 26, 267–298. (10.1146/annurev.neuro.26.010302.081142)
  8. Wyttenbach, A., Carmichael, J., Swartz, J., Furlong, R.A., Narain, Y., Rankin, J. and Rubinsztein, D.C. (2000) Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease. Proc. Natl Acad. Sci. USA, 97, 2898–2903. (10.1073/pnas.97.6.2898)
  9. Cummings, C.J., Mancini, M.A., Antalffy, B., DeFranco, D.B., Orr, H.T. and Zoghbi, H.Y. (1998) Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1. Nat. Genet., 19, 148–154. (10.1038/502)
  10. Jana, N.R., Tanaka, M., Wang, G. and Nukina, N. (2000) Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity. Hum. Mol. Genet., 9, 2009–2018. (10.1093/hmg/9.13.2009)
  11. Auluck, P.K., Chan, H.Y., Trojanowski, J.Q., Lee, V.M. and Bonini, N.M. (2002) Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science, 295, 865–868. (10.1126/science.1067389)
  12. Wyttenbach, A., Sauvageot, O., Carmichael, J., Diaz-Latoud, C., Arrigo, A.P. and Rubinsztein, D.C. (2002) Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin. Hum. Mol. Genet., 11, 1137–1151. (10.1093/hmg/11.9.1137)
  13. Kobayashi, Y., Kume, A., Li, M., Doyu, M., Hata, M., Ohtsuka, K. and Sobue, G. (2000) Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract. J. Biol. Chem., 275, 8772–8778. (10.1074/jbc.275.12.8772)
  14. Warrick, J.M., Chan, H.Y., Gray-Board, G.L., Chai, Y., Paulson, H.L. and Bonini, N.M. (1999) Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70. Nat. Genet., 23, 425–428. (10.1038/70532)
  15. Chan, H.Y., Warrick, J.M., Gray-Board, G.L., Paulson, H.L. and Bonini, N.M. (2000) Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila. Hum. Mol. Genet., 9, 2811–2820. (10.1093/hmg/9.19.2811)
  16. Cummings, C.J., Sun, Y., Opal, P., Antalffy, B., Mestril, R., Orr, H.T., Dillmann, W.H. and Zoghbi, H.Y. (2001) Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice. Hum. Mol. Genet., 10, 1511–1518. (10.1093/hmg/10.14.1511)
  17. Hay, D.G., Sathasivam, K., Tobaben, S., Stahl, B., Marber, M., Mestril, R., Mahal, A., Smith, D.L., Woodman, B. and Bates, G.P. (2004) Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach. Hum. Mol. Genet., 13, 1389–1405. (10.1093/hmg/ddh144)
  18. Hansson, O., Nylandsted, J., Castilho, R.F., Leist, M., Jaattela, M. and Brundin, P. (2003) Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression. Brain Res., 970, 47–57. (10.1016/S0006-8993(02)04275-0)
  19. Helmlinger, D., Bonnet, J., Mandel, J.L., Trottier, Y. and Devys, D. (2004) Hsp70 and Hsp40 chaperones do not modulate retinal phenotype in SCA7 mice. J. Biol. Chem., 279, 55969–55977. (10.1074/jbc.M409062200)
  20. Saleh, A., Srinivasula, S.M., Balkir, L., Robbins, P.D. and Alnemri, E.S. (2000) Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat. Cell Biol., 2, 476–483. (10.1038/35019510)
  21. Lee, S., Sowa, M.E., Choi, J.M. and Tsai, F.T. (2004) The ClpB/Hsp104 molecular chaperone-a protein disaggregating machine. J. Struct. Biol., 146, 99–105. (10.1016/j.jsb.2003.11.016)
  22. Mogk, A. and Bukau, B. (2004) Molecular chaperones: structure of a protein disaggregase. Curr. Biol., 14, R78–R80. (10.1016/j.cub.2003.12.051)
  23. Glover, J.R. and Lindquist, S. (1998) Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins. Cell, 94, 73–82. (10.1016/S0092-8674(00)81223-4)
  24. Krobitsch, S. and Lindquist, S. (2000) Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins. Proc. Natl Acad. Sci. USA, 97, 1589–1594. (10.1073/pnas.97.4.1589)
  25. Satyal, S.H., Schmidt, E., Kitagawa, K., Sondheimer, N., Lindquist, S., Kramer, J.M. and Morimoto, R.I. (2000) Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans. Proc. Natl Acad. Sci. USA, 97, 5750–5755. (10.1073/pnas.100107297)
  26. Mosser, D.D., Ho, S. and Glover, J.R. (2004) Saccharomyces cerevisiae Hsp104 enhances the chaperone capacity of human cells and inhibits heat stress-induced proapoptotic signaling. Biochemistry, 43, 8107–8115. (10.1021/bi0493766)
  27. Carmichael, J., Chatellier, J., Woolfson, A., Milstein, C., Fersht, A.R. and Rubinsztein, D.C. (2000) Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease. Proc. Natl Acad. Sci. USA, 97, 9701–9705. (10.1073/pnas.170280697)
  28. Bao, Y.P., Cook, L.J., O'Donovan, D., Uyama, E. and Rubinsztein, D.C. (2002) Mammalian, yeast, bacterial, and chemical chaperones reduce aggregate formation and death in a cell model of oculopharyngeal muscular dystrophy. J. Biol. Chem., 277, 12263–12269. (10.1074/jbc.M109633200)
  29. Schilling, G., Becher, M.W., Sharp, A.H., Jinnah, H.A., Duan, K., Kotzuk, J.A., Slunt, H.H., Ratovitski, T., Cooper, J.K., Jenkins, N.A. et al. (1999) Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Hum. Mol. Genet., 8, 397–407. (10.1093/hmg/8.3.397)
  30. Borchelt, D.R., Davis, J., Fischer, M., Lee, M.K., Slunt, H.H., Ratovitsky, T., Regard, J., Copeland, N.G., Jenkins, N.A., Sisodia, S.S. et al. (1996) A vector for expressing foreign genes in the brains and hearts of transgenic mice. Genet. Anal., 13, 159–163. (10.1016/S1050-3862(96)00167-2)
  31. Ferrante, R.J., Ryu, H., Kubilus, J.K., D'Mello, S., Sugars, K.L., Lee, J., Lu, P., Smith, K., Browne, S., Beal, M.F. et al. (2004) Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease. J. Neurosci., 24, 10335–10342. (10.1523/JNEUROSCI.2599-04.2004)
  32. Gardian, G., Browne, S.E., Choi, D.K., Klivenyi, P., Gregorio, J., Kubilus, J.K., Ryu, H., Langley, B., Ratan, R.R., Ferrante, R.J. et al. (2005) Neuroprotective effects of phenylbutyrate in the N171–82Q transgenic mouse model of Huntington's disease. J. Biol. Chem., 280, 556–563. (10.1074/jbc.M410210200)
  33. Krzewska, J., Konopa, G. and Liberek, K. (2001) Importance of two ATP-binding sites for oligomerization, ATPase activity and chaperone function of mitochondrial Hsp78 protein. J. Mol. Biol., 314, 901–910. (10.1006/jmbi.2001.5190)
  34. Skinner, P.J., Vierra-Green, C.A., Emamian, E., Zoghbi, H.Y. and Orr, H.T. (2002) Amino acids in a region of ataxin-1 outside of the polyglutamine tract influence the course of disease in SCA1 transgenic mice. Neuromolecular Med., 1, 33–42. (10.1385/NMM:1:1:33)
  35. Davies, S.W., Sathasivam, K., Hobbs, C., Doherty, P., Mangiarini, L., Scherzinger, E., Wanker, E.E. and Bates, G.P. (1999) Detection of polyglutamine aggregation in mouse models. Methods Enzymol., 309, 687–701. (10.1016/S0076-6879(99)09045-X)
Dates
Type When
Created 19 years, 10 months ago (Oct. 4, 2005, 7:18 p.m.)
Deposited 6 years, 4 months ago (March 27, 2019, 1:42 a.m.)
Indexed 19 hours, 6 minutes ago (Aug. 26, 2025, 2:35 a.m.)
Issued 19 years, 10 months ago (Oct. 4, 2005)
Published 19 years, 10 months ago (Oct. 4, 2005)
Published Online 19 years, 10 months ago (Oct. 4, 2005)
Published Print 19 years, 9 months ago (Nov. 15, 2005)
Funders 0

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@article{Vacher_2005, title={Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington’s disease}, volume={14}, ISSN={0964-6906}, url={http://dx.doi.org/10.1093/hmg/ddi372}, DOI={10.1093/hmg/ddi372}, number={22}, journal={Human Molecular Genetics}, publisher={Oxford University Press (OUP)}, author={Vacher, Coralie and Garcia-Oroz, Lourdes and Rubinsztein, David C.}, year={2005}, month=oct, pages={3425–3433} }