DOI: 10.1093/genetics/81.1.99. NEGATIVE COMPLEMENTATION AT THE NOTCH LOCUS OF <i>DROSOPHILA MELANOGASTER</i>

NEGATIVE COMPLEMENTATION AT THE NOTCH LOCUS OF DROSOPHILA MELANOGASTER

10.1093/genetics/81.1.99

Crossref journal-article

Oxford University Press (OUP)

Genetics (286)

Abstract

ABSTRACT Four Abruptex alleles (AxE1, AxE 2, Ax9 B 2, and Ax16172) have been mapped within the Notch locus. Based on their visible phenotypes and their interactions with one another and with N mutations, the Ax alleles can be divided into two groups. Heterozygous combinations of members of the same group are intermediate in phenotype compared to the respective homozygotes, whereas heterozygotes of Ax alleles from different groups exhibit negative heterosis, being much less viable and more extremely mutant than either homozygote. It is suggested that the Notch locus is a multi-functional regulator ("integrator") gene, whose product possesses both "repressor" and "activator" functions for the processes it regulates.

Bibliography

Foster, G. G. (1975). NEGATIVE COMPLEMENTATION AT THE NOTCH LOCUS OF DROSOPHILA MELANOGASTER. Genetics, 81(1), 99â120.

Authors 1

Geoffrey G Foster (first)

References 0 Referenced 51

None

Dates

Type	When
Created	4 years, 7 months ago (Jan. 14, 2021, 11:28 a.m.)
Deposited	4 years, 4 months ago (April 21, 2021, 3:38 a.m.)
Indexed	1 year, 2 months ago (June 26, 2024, 10:30 a.m.)
Issued	49 years, 11 months ago (Sept. 1, 1975)
Published	49 years, 11 months ago (Sept. 1, 1975)
Published Online	49 years, 11 months ago (Sept. 1, 1975)
Published Print	49 years, 11 months ago (Sept. 1, 1975)

Funders 0

None

BibTeX

@article{Foster_1975, title={NEGATIVE COMPLEMENTATION AT THE NOTCH LOCUS OF DROSOPHILA MELANOGASTER}, volume={81}, ISSN={1943-2631}, url={http://dx.doi.org/10.1093/genetics/81.1.99}, DOI={10.1093/genetics/81.1.99}, number={1}, journal={Genetics}, publisher={Oxford University Press (OUP)}, author={Foster, Geoffrey G}, year={1975}, month=sep, pages={99–120} }

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