DOI: 10.1093/genetics/163.2.685. Alternative Transcription Initiation Sites and Polyadenylation Sites Are Recruited During <i>Mu</i> Suppression at the <i>rf2a</i> Locus of Maize

Alternative Transcription Initiation Sites and Polyadenylation Sites Are Recruited During Mu Suppression at the rf2a Locus of Maize

10.1093/genetics/163.2.685

Crossref journal-article

Oxford University Press (OUP)

Genetics (286)

Abstract

Abstract Even in the absence of excisional loss of the associated Mu transposons, some Mu-induced mutant alleles of maize can lose their capacity to condition a mutant phenotype. Three of five Mu-derived rf2a alleles are susceptible to such Mu suppression. The suppressible rf2a-m9437 allele has a novel Mu transposon insertion (Mu10) in its 5′ untranslated region (UTR). The suppressible rf2a-m9390 allele has a Mu1 insertion in its 5′ UTR. During suppression, alternative transcription initiation sites flanking the Mu1 transposon yield functional transcripts. The suppressible rf2a-m8110 allele has an rcy/Mu7 insertion in its 3′ UTR. Suppression of this allele occurs via a previously unreported mechanism; sequences in the terminal inverted repeats of rcy/Mu7 function as alternative polyadenylation sites such that the suppressed rf2a-m8110 allele yields functional rf2a transcripts. No significant differences were observed in the nucleotide compositions of these alternative polyadenylation sites as compared with 94 other polyadenylation sites from maize genes.

Bibliography

Cui, X., Hsia, A.-P., Liu, F., Ashlock, D. A., Wise, R. P., & Schnable, P. S. (2003). Alternative Transcription Initiation Sites and Polyadenylation Sites Are Recruited During Mu Suppression at the rf2a Locus of Maize. Genetics, 163(2), 685â698.

Authors 6

Xiangqin Cui (first)
An-Ping Hsia (additional)
Feng Liu (additional)
Daniel A Ashlock (additional)
Roger P Wise (additional)
Patrick S Schnable (additional)

References 61 Referenced 22

{'key': '2022010519232724400_R1', 'volume-title': 'Current Protocols in Molecular Biology', 'author': 'Ausubel', 'year': '1999'} / Current Protocols in Molecular Biology by Ausubel (1999)
10.1073/pnas.88.8.3502 / Proc. Natl. Acad. Sci. USA / Inactivation of maize transposon Mu suppresses a mutant phenotype by activating an outward-reading promoter near the end of Mu1. by Barkan (1991)
10.1006/geno.2000.6175 / Genomics / HERV-K-T47D-related long terminal repeats mediate polyadenylation of cellular transcripts by Baust (2000)
10.1128/MCB.17.9.5165 / Mol. Cell. Biol. / Characterization of the maize Mutator transposable element MURA transposase as a DNA-binding protein by Benito (1997)
{'key': '2022010519232724400_R5', 'first-page': '195', 'article-title': 'The Mutator transposable element system of maize', 'volume': '204', 'author': 'Bennetzen', 'year': '1996', 'journal-title': 'Curr. Top. Microbiol. Immunol.'} / Curr. Top. Microbiol. Immunol. / The Mutator transposable element system of maize by Bennetzen (1996)
10.1080/07352689309382356 / Crit. Rev. Plant Sci. / Specificity and regulation of the Mutator transposable element system of maize by Bennetzen (1993)
{'key': '2022010519232724400_R7', 'first-page': '75', 'article-title': 'Cloning and characterization of the maize An1 gene', 'volume': '7', 'author': 'Bensen', 'year': '1995', 'journal-title': 'Plant Cell'} / Plant Cell / Cloning and characterization of the maize An1 gene by Bensen (1995)
10.1016/S0065-2660(08)60319-3 / Adv. Genet. / The Mu elements of Zea mays. by Chandler (1992)
10.1073/pnas.83.6.1767 / Proc. Natl. Acad. Sci. USA / DNA modification of a maize transposable element correlates with loss of activity by Chandler (1986)
10.1093/genetics/129.1.261 / Genetics / Identification of a regulatory transposon that controls the Mutator transposable element system in maize by Chomet (1991)
10.1126/science.272.5266.1334 / Science / The rf 2 nuclear restorer gene of male sterile T-cytoplasm maize by Cui (1996)
10.1002/j.1460-2075.1985.tb04045.x / EMBO J. / Differential expression of the eight genes of the petunia ribulose bisphosphate carboxylase small subunit multigene family by Dean (1985)
10.1093/genetics/160.2.697 / Genetics / Maize Mu transposons are targeted to the 5′ untranslated region of the gl8 gene and sequences flanking Mu target-site duplications exhibit nonrandom nucleotide composition throughout the genome by Dietrich (2002)
{'key': '2022010519232724400_R14', 'first-page': '1989', 'article-title': 'Tissue-specific accumulation of MURB, a protein encoded by MuDR, the autonomous regulator of the Mutator transposable element family', 'volume': '7', 'author': 'Donlin', 'year': '1995', 'journal-title': 'Plant Cell'} / Plant Cell / Tissue-specific accumulation of MURB, a protein encoded by MuDR, the autonomous regulator of the Mutator transposable element family by Donlin (1995)
10.1093/nar/22.13.2634 / Nucleic Acids Res. / Sequence similarity of putative transposases links the maize Mutator autonomous element and a group of bacterial insertion sequences by Eisen (1994)
10.1046/j.1365-2443.1999.00233.x / Genes Cells / The suppressor-mutator element and the evolutionary riddle of transposons by Fedoroff (1999)
10.1093/genetics/143.1.489 / Genetics / Mosaic analysis of the liguleless3 mutant phenotype in maize by coordinate suppression of Mutator-insertion alleles by Fowler (1996)
10.1093/genetics/154.1.437 / Genetics / Mutator-suppression alleles of rough sheath1 and liguleless3 in maize reveal multiple mechanisms for suppression by Girard (2000)
10.1073/pnas.96.24.14055 / Proc. Natl. Acad. Sci. USA / In silico detection of control signals: mRNA 3′-end-processing sequences in diverse species by Graber (1999)
10.1093/genetics/138.4.1275 / Genetics / Mutator insertions in an intron of the maize knotted1 gene result in dominant suppressible mutations by Greene (1994)
10.1128/MCB.15.11.5983 / Mol. Cell. Biol. / 3′end-forming signals of yeast mRNA by Guo (1995)
10.1073/pnas.88.22.10198 / Proc. Natl. Acad. Sci. USA / Mutator activity in maize correlates with the presence and expression of the Mu transposable element Mu9. by Hershberger (1991)
10.1093/genetics/142.2.603 / Genetics / DNA sequence analyses support the role of interrupted gap repair in the origin of internal deletions of the maize transposon, MuDR. by Hsia (1996)
10.1105/tpc.10.7.1095 / Plant Cell / A porphyrin pathway impairment is responsible for the phenotype of a dominant disease lesion mimic mutant of maize by Hu (1998)
{'key': '2022010519232724400_R25', 'first-page': '29', 'article-title': 'mRNA polyadenylation in plants', 'volume-title': 'A Look Beyond Transcription: Mechanisms Determining mRNA Stability and Translation in Plants', 'author': 'Hunt', 'year': '1998'} / A Look Beyond Transcription: Mechanisms Determining mRNA Stability and Translation in Plants / mRNA polyadenylation in plants by Hunt (1998)
10.1007/BF00023614 / Plant Mol. Biol. / DNA sequence and transcript analysis of transposon MuA2, a regulator of Mutator transposable element activity in maize by James (1993)
10.1093/genetics/127.4.801 / Genetics / A superfamily of Arabidopsis thaliana retrotransposons by Konieczny (1991)
{'key': '2022010519232724400_R28', 'first-page': '161', 'article-title': 'The maize transposable element activator (Ac)', 'volume': '204', 'author': 'Kunze', 'year': '1996', 'journal-title': 'Curr. Top. Microbiol. Immunol.'} / Curr. Top. Microbiol. Immunol. / The maize transposable element activator (Ac) by Kunze (1996)
10.1093/genetics/151.1.331 / Genetics / Functional analysis of deletion derivatives of the maize transposon MuDR delineates roles for the MURA and MURB proteins by Lisch (1999)
10.1105/tpc.13.5.1063 / Plant Cell / Mitochondrial aldehyde dehydrogenase activity is required for male fertility in maize (Zea mays L.) by Liu (2001)
10.1093/genetics/132.3.813 / Genetics / Active Mutator elements suppress the Knotted phenotype and increase recombination at the Kn1-0 tandem duplication by Lowe (1992)
10.1006/geno.1999.5877 / Genomics / Endogenous retroviruses provide the primary polyadenylation signal for two new human genes (HHLA2 and HHLA3) by Mager (1999)
10.1093/genetics/136.3.1157 / Genetics / Coordinate suppression of mutations caused by Robertson’s Mutator transposons in maize by Martienssen (1994)
10.1002/j.1460-2075.1989.tb03553.x / EMBO J. / Molecular cloning of a maize gene involved in photosynthetic membrane organization that is regulated by Robertson’s Mutator. by Martienssen (1989)
10.1101/gad.4.3.331 / Genes Dev. / Somatically heritable switches in the DNA modification of Mu transposable elements monitored with a suppressible mutant in maize by Martienssen (1990)
10.1016/0300-9084(91)90067-B / Biochimie / Structure and function of the maize Spm transposable element by Masson (1991)
{'key': '2022010519232724400_R37', 'first-page': '592', 'article-title': 'Aspects of gene regulation in maize', 'volume': '63', 'author': 'McClintock', 'year': '1964', 'journal-title': 'Carnegie Inst. Wash. Year Book'} / Carnegie Inst. Wash. Year Book / Aspects of gene regulation in maize by McClintock (1964)
{'key': '2022010519232724400_R38', 'first-page': '84', 'article-title': 'Genetic systems regulating gene expression during development', 'volume': '1', 'author': 'McClintock', 'year': '1967', 'journal-title': 'Dev. Biol. Suppl.'} / Dev. Biol. Suppl. / Genetic systems regulating gene expression during development by McClintock (1967)
{'key': '2022010519232724400_R39', 'first-page': '2090', 'article-title': 'The Mu1 maize transposable element induces tissue-specific aberrant splicing and polyadenylation in two Adh1 mutants', 'volume': '10', 'author': 'Ortiz', 'year': '1990', 'journal-title': 'Mol. Cell. Biol.'} / Mol. Cell. Biol. / The Mu1 maize transposable element induces tissue-specific aberrant splicing and polyadenylation in two Adh1 mutants by Ortiz (1990)
10.1016/S0168-9525(99)01749-7 / Trends Genet. / Suppression mechanisms: themes from variations by Prelich (1999)
10.1093/genetics/129.3.845 / Genetics / Cloning of the Mutator transposable element MuA2, a putative regulator of somatic mutability of the a1-Mum2 allele in maize by Qin (1991)
{'key': '2022010519232724400_R42', 'first-page': '5', 'article-title': 'The late developmental pattern of Mu transposon excision is conferred by a cauliflower mosaic virus 35S-driven MURA cDNA in transgenic maize', 'volume': '12', 'author': 'Raizada', 'year': '2000', 'journal-title': 'Plant Cell'} / Plant Cell / The late developmental pattern of Mu transposon excision is conferred by a cauliflower mosaic virus 35S-driven MURA cDNA in transgenic maize by Raizada (2000)
10.1016/0027-5107(78)90004-0 / Mutat. Res. / Characterization of a mutator system in maize by Robertson (1978)
10.1002/dvg.1020100609 / Dev. Genet. / Genetic analyses of putative two-element system regulating somatic mutability in mutator-induced aleurone mutants of maize by Robertson (1989)
10.1007/978-1-4684-5550-2_2 / Plant Transposable Elements / Germline and somatic Mutator activity: Are they functionally related? by Robertson (1988)
10.1007/BF00039376 / Plant Mol. Biol. / Plant mRNA 3′-end formation by Rothnie (1996)
10.1073/pnas.81.24.8014 / Proc. Natl. Acad. Sci. USA / Ribosomal DNA spacer-length polymorphisms in barley: Mendelian inheritance, chromosomal location, and population dynamics by Saghai-Maroof (1984)
{'key': '2022010519232724400_R48', 'first-page': '59', 'article-title': 'Distribution of genetically active Cy elements among diverse maize lines', 'volume': '31', 'author': 'Schnable', 'year': '1986', 'journal-title': 'Maydica'} / Maydica / Distribution of genetically active Cy elements among diverse maize lines by Schnable (1986)
10.1093/genetics/136.3.1171 / Genetics / Recovery of heritable, transposon-induced, mutant alleles of the rf 2 nuclear restorer of T-cytoplasm maize by Schnable (1994)
10.1016/S1360-1385(98)01235-7 / Trends Plant Sci. / The molecular basis of cytoplasmic male sterility and fertility restoration by Schnable (1998)
10.1007/BF02464917 / Mol. Gen. Genet. / The bz-rcy allele of the Cy transposable element system of Zea mays contains a Mu-like element insertion by Schnable (1989)
10.1093/nar/18.19.5799 / Nucleic Acids Res. / Point mutations in AAUAAA and the poly (A) addition site: effects on the accuracy and efficiency of cleavage and polyadenylation in vitro. by Sheets (1990)
10.1023/A:1014870429630 / Plant. Mol. Biol. / Characterization of the aldehyde dehydrogenase gene families of Zea mays and Arabidopsis by Skibbe (2002)
{'key': '2022010519232724400_R54', 'volume-title': 'Principles and Procedures of Statistics: A Biometrical Approach', 'author': 'Steel', 'year': '1980'} / Principles and Procedures of Statistics: A Biometrical Approach by Steel (1980)
10.1073/pnas.88.4.1247 / Proc. Natl. Acad. Sci. USA / Transposon-facilitated DNA sequencing by Strathmann (1991)
10.1016/S0168-6445(99)00008-X / FEMS Microbiol. Rev. / 3′-end processing of pre-mRNA in eukaryotes by Wahle (1999)
10.1104/pp.119.4.1151 / Plant Physiol. / Genes, genomes, genomics. What can plant biologists expect from the 1998 National Science Foundation Plant Genome Research Program? by Walbot (1999)
10.1016/S0065-2113(08)60911-6 / Adv. Agronomy / The genetics, pathology, and molecular biology of T-cytoplasm male sterility in maize by Wise (1999)
10.1046/j.1365-313X.1995.08030323.x / Plant J. / The formation of mRNA 3′-ends in plants by Wu (1995)
10.1104/pp.115.2.501 / Plant Physiol. / Sequence analysis of the cloned glossy8 gene of maize suggests that it may code for a beta-ketoacyl reductase required for the biosynthesis of cuticular waxes by Xu (1997)
10.1128/MMBR.63.2.405-445.1999 / Microbiol. Mol. Biol. Rev. / Formation of mRNA 3′ ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis by Zhao (1999)

Dates

Type	When
Created	4 years, 4 months ago (April 23, 2021, 1:29 a.m.)
Deposited	3 years, 7 months ago (Jan. 5, 2022, 2:24 p.m.)
Indexed	1 year ago (Aug. 4, 2024, 1:54 p.m.)
Issued	22 years, 7 months ago (Feb. 1, 2003)
Published	22 years, 7 months ago (Feb. 1, 2003)
Published Online	22 years, 7 months ago (Feb. 1, 2003)
Published Print	22 years, 7 months ago (Feb. 1, 2003)

Funders 0

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BibTeX

@article{Cui_2003, title={Alternative Transcription Initiation Sites and Polyadenylation Sites Are Recruited During Mu Suppression at the rf2a Locus of Maize}, volume={163}, ISSN={1943-2631}, url={http://dx.doi.org/10.1093/genetics/163.2.685}, DOI={10.1093/genetics/163.2.685}, number={2}, journal={Genetics}, publisher={Oxford University Press (OUP)}, author={Cui, Xiangqin and Hsia, An-Ping and Liu, Feng and Ashlock, Daniel A and Wise, Roger P and Schnable, Patrick S}, year={2003}, month=feb, pages={685–698} }

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  "abstract": "<jats:title>Abstract</jats:title>\n               <jats:p>Even in the absence of excisional loss of the associated Mu transposons, some Mu-induced mutant alleles of maize can lose their capacity to condition a mutant phenotype. Three of five Mu-derived rf2a alleles are susceptible to such Mu suppression. The suppressible rf2a-m9437 allele has a novel Mu transposon insertion (Mu10) in its 5\u2032 untranslated region (UTR). The suppressible rf2a-m9390 allele has a Mu1 insertion in its 5\u2032 UTR. During suppression, alternative transcription initiation sites flanking the Mu1 transposon yield functional transcripts. The suppressible rf2a-m8110 allele has an rcy/Mu7 insertion in its 3\u2032 UTR. Suppression of this allele occurs via a previously unreported mechanism; sequences in the terminal inverted repeats of rcy/Mu7 function as alternative polyadenylation sites such that the suppressed rf2a-m8110 allele yields functional rf2a transcripts. No significant differences were observed in the nucleotide compositions of these alternative polyadenylation sites as compared with 94 other polyadenylation sites from maize genes.</jats:p>",
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    {
      "key": "2022010519232724400_R1",
      "volume-title": "Current Protocols in Molecular Biology",
      "author": "Ausubel",
      "year": "1999"
    },
    {
      "key": "2022010519232724400_R2",
      "doi-asserted-by": "crossref",
      "first-page": "3502",
      "DOI": "10.1073/pnas.88.8.3502",
      "article-title": "Inactivation of maize transposon Mu suppresses a mutant phenotype by activating an outward-reading promoter near the end of Mu1.",
      "volume": "88",
      "author": "Barkan",
      "year": "1991",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2022010519232724400_R3",
      "doi-asserted-by": "crossref",
      "first-page": "98",
      "DOI": "10.1006/geno.2000.6175",
      "article-title": "HERV-K-T47D-related long terminal repeats mediate polyadenylation of cellular transcripts",
      "volume": "66",
      "author": "Baust",
      "year": "2000",
      "journal-title": "Genomics"
    },
    {
      "key": "2022010519232724400_R4",
      "doi-asserted-by": "crossref",
      "first-page": "5165",
      "DOI": "10.1128/MCB.17.9.5165",
      "article-title": "Characterization of the maize Mutator transposable element MURA transposase as a DNA-binding protein",
      "volume": "17",
      "author": "Benito",
      "year": "1997",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "2022010519232724400_R5",
      "first-page": "195",
      "article-title": "The Mutator transposable element system of maize",
      "volume": "204",
      "author": "Bennetzen",
      "year": "1996",
      "journal-title": "Curr. Top. Microbiol. Immunol."
    },
    {
      "key": "2022010519232724400_R6",
      "doi-asserted-by": "crossref",
      "first-page": "57",
      "DOI": "10.1080/07352689309382356",
      "article-title": "Specificity and regulation of the Mutator transposable element system of maize",
      "volume": "12",
      "author": "Bennetzen",
      "year": "1993",
      "journal-title": "Crit. Rev. Plant Sci."
    },
    {
      "key": "2022010519232724400_R7",
      "first-page": "75",
      "article-title": "Cloning and characterization of the maize An1 gene",
      "volume": "7",
      "author": "Bensen",
      "year": "1995",
      "journal-title": "Plant Cell"
    },
    {
      "key": "2022010519232724400_R8",
      "doi-asserted-by": "crossref",
      "first-page": "77",
      "DOI": "10.1016/S0065-2660(08)60319-3",
      "article-title": "The Mu elements of Zea mays.",
      "volume": "30",
      "author": "Chandler",
      "year": "1992",
      "journal-title": "Adv. Genet."
    },
    {
      "key": "2022010519232724400_R9",
      "doi-asserted-by": "crossref",
      "first-page": "1767",
      "DOI": "10.1073/pnas.83.6.1767",
      "article-title": "DNA modification of a maize transposable element correlates with loss of activity",
      "volume": "83",
      "author": "Chandler",
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    },
    {
      "key": "2022010519232724400_R10",
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      "first-page": "261",
      "DOI": "10.1093/genetics/129.1.261",
      "article-title": "Identification of a regulatory transposon that controls the Mutator transposable element system in maize",
      "volume": "129",
      "author": "Chomet",
      "year": "1991",
      "journal-title": "Genetics"
    },
    {
      "key": "2022010519232724400_R11",
      "doi-asserted-by": "crossref",
      "first-page": "1334",
      "DOI": "10.1126/science.272.5266.1334",
      "article-title": "The rf 2 nuclear restorer gene of male sterile T-cytoplasm maize",
      "volume": "272",
      "author": "Cui",
      "year": "1996",
      "journal-title": "Science"
    },
    {
      "key": "2022010519232724400_R12",
      "doi-asserted-by": "crossref",
      "first-page": "3055",
      "DOI": "10.1002/j.1460-2075.1985.tb04045.x",
      "article-title": "Differential expression of the eight genes of the petunia ribulose bisphosphate carboxylase small subunit multigene family",
      "volume": "4",
      "author": "Dean",
      "year": "1985",
      "journal-title": "EMBO J."
    },
    {
      "key": "2022010519232724400_R13",
      "doi-asserted-by": "crossref",
      "first-page": "697",
      "DOI": "10.1093/genetics/160.2.697",
      "article-title": "Maize Mu transposons are targeted to the 5\u2032 untranslated region of the gl8 gene and sequences flanking Mu target-site duplications exhibit nonrandom nucleotide composition throughout the genome",
      "volume": "160",
      "author": "Dietrich",
      "year": "2002",
      "journal-title": "Genetics"
    },
    {
      "key": "2022010519232724400_R14",
      "first-page": "1989",
      "article-title": "Tissue-specific accumulation of MURB, a protein encoded by MuDR, the autonomous regulator of the Mutator transposable element family",
      "volume": "7",
      "author": "Donlin",
      "year": "1995",
      "journal-title": "Plant Cell"
    },
    {
      "key": "2022010519232724400_R15",
      "doi-asserted-by": "crossref",
      "first-page": "2634",
      "DOI": "10.1093/nar/22.13.2634",
      "article-title": "Sequence similarity of putative transposases links the maize Mutator autonomous element and a group of bacterial insertion sequences",
      "volume": "22",
      "author": "Eisen",
      "year": "1994",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "2022010519232724400_R16",
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      "first-page": "11",
      "DOI": "10.1046/j.1365-2443.1999.00233.x",
      "article-title": "The suppressor-mutator element and the evolutionary riddle of transposons",
      "volume": "4",
      "author": "Fedoroff",
      "year": "1999",
      "journal-title": "Genes Cells"
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      "first-page": "489",
      "DOI": "10.1093/genetics/143.1.489",
      "article-title": "Mosaic analysis of the liguleless3 mutant phenotype in maize by coordinate suppression of Mutator-insertion alleles",
      "volume": "143",
      "author": "Fowler",
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      "journal-title": "Genetics"
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      "DOI": "10.1093/genetics/154.1.437",
      "article-title": "Mutator-suppression alleles of rough sheath1 and liguleless3 in maize reveal multiple mechanisms for suppression",
      "volume": "154",
      "author": "Girard",
      "year": "2000",
      "journal-title": "Genetics"
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      "key": "2022010519232724400_R19",
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      "first-page": "14055",
      "DOI": "10.1073/pnas.96.24.14055",
      "article-title": "In silico detection of control signals: mRNA 3\u2032-end-processing sequences in diverse species",
      "volume": "96",
      "author": "Graber",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2022010519232724400_R20",
      "doi-asserted-by": "crossref",
      "first-page": "1275",
      "DOI": "10.1093/genetics/138.4.1275",
      "article-title": "Mutator insertions in an intron of the maize knotted1 gene result in dominant suppressible mutations",
      "volume": "138",
      "author": "Greene",
      "year": "1994",
      "journal-title": "Genetics"
    },
    {
      "key": "2022010519232724400_R21",
      "doi-asserted-by": "crossref",
      "first-page": "5983",
      "DOI": "10.1128/MCB.15.11.5983",
      "article-title": "3\u2032end-forming signals of yeast mRNA",
      "volume": "15",
      "author": "Guo",
      "year": "1995",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "2022010519232724400_R22",
      "doi-asserted-by": "crossref",
      "first-page": "10198",
      "DOI": "10.1073/pnas.88.22.10198",
      "article-title": "Mutator activity in maize correlates with the presence and expression of the Mu transposable element Mu9.",
      "volume": "88",
      "author": "Hershberger",
      "year": "1991",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2022010519232724400_R23",
      "doi-asserted-by": "crossref",
      "first-page": "603",
      "DOI": "10.1093/genetics/142.2.603",
      "article-title": "DNA sequence analyses support the role of interrupted gap repair in the origin of internal deletions of the maize transposon, MuDR.",
      "volume": "142",
      "author": "Hsia",
      "year": "1996",
      "journal-title": "Genetics"
    },
    {
      "key": "2022010519232724400_R24",
      "doi-asserted-by": "crossref",
      "first-page": "1095",
      "DOI": "10.1105/tpc.10.7.1095",
      "article-title": "A porphyrin pathway impairment is responsible for the phenotype of a dominant disease lesion mimic mutant of maize",
      "volume": "10",
      "author": "Hu",
      "year": "1998",
      "journal-title": "Plant Cell"
    },
    {
      "key": "2022010519232724400_R25",
      "first-page": "29",
      "article-title": "mRNA polyadenylation in plants",
      "volume-title": "A Look Beyond Transcription: Mechanisms Determining mRNA Stability and Translation in Plants",
      "author": "Hunt",
      "year": "1998"
    },
    {
      "key": "2022010519232724400_R26",
      "doi-asserted-by": "crossref",
      "first-page": "1181",
      "DOI": "10.1007/BF00023614",
      "article-title": "DNA sequence and transcript analysis of transposon MuA2, a regulator of Mutator transposable element activity in maize",
      "volume": "21",
      "author": "James",
      "year": "1993",
      "journal-title": "Plant Mol. Biol."
    },
    {
      "key": "2022010519232724400_R27",
      "doi-asserted-by": "crossref",
      "first-page": "801",
      "DOI": "10.1093/genetics/127.4.801",
      "article-title": "A superfamily of Arabidopsis thaliana retrotransposons",
      "volume": "127",
      "author": "Konieczny",
      "year": "1991",
      "journal-title": "Genetics"
    },
    {
      "key": "2022010519232724400_R28",
      "first-page": "161",
      "article-title": "The maize transposable element activator (Ac)",
      "volume": "204",
      "author": "Kunze",
      "year": "1996",
      "journal-title": "Curr. Top. Microbiol. Immunol."
    },
    {
      "key": "2022010519232724400_R29",
      "doi-asserted-by": "crossref",
      "first-page": "331",
      "DOI": "10.1093/genetics/151.1.331",
      "article-title": "Functional analysis of deletion derivatives of the maize transposon MuDR delineates roles for the MURA and MURB proteins",
      "volume": "151",
      "author": "Lisch",
      "year": "1999",
      "journal-title": "Genetics"
    },
    {
      "key": "2022010519232724400_R30",
      "doi-asserted-by": "crossref",
      "first-page": "1063",
      "DOI": "10.1105/tpc.13.5.1063",
      "article-title": "Mitochondrial aldehyde dehydrogenase activity is required for male fertility in maize (Zea mays L.)",
      "volume": "13",
      "author": "Liu",
      "year": "2001",
      "journal-title": "Plant Cell"
    },
    {
      "key": "2022010519232724400_R31",
      "doi-asserted-by": "crossref",
      "first-page": "813",
      "DOI": "10.1093/genetics/132.3.813",
      "article-title": "Active Mutator elements suppress the Knotted phenotype and increase recombination at the Kn1-0 tandem duplication",
      "volume": "132",
      "author": "Lowe",
      "year": "1992",
      "journal-title": "Genetics"
    },
    {
      "key": "2022010519232724400_R32",
      "doi-asserted-by": "crossref",
      "first-page": "255",
      "DOI": "10.1006/geno.1999.5877",
      "article-title": "Endogenous retroviruses provide the primary polyadenylation signal for two new human genes (HHLA2 and HHLA3)",
      "volume": "59",
      "author": "Mager",
      "year": "1999",
      "journal-title": "Genomics"
    },
    {
      "key": "2022010519232724400_R33",
      "doi-asserted-by": "crossref",
      "first-page": "1157",
      "DOI": "10.1093/genetics/136.3.1157",
      "article-title": "Coordinate suppression of mutations caused by Robertson\u2019s Mutator transposons in maize",
      "volume": "136",
      "author": "Martienssen",
      "year": "1994",
      "journal-title": "Genetics"
    },
    {
      "key": "2022010519232724400_R34",
      "doi-asserted-by": "crossref",
      "first-page": "1633",
      "DOI": "10.1002/j.1460-2075.1989.tb03553.x",
      "article-title": "Molecular cloning of a maize gene involved in photosynthetic membrane organization that is regulated by Robertson\u2019s Mutator.",
      "volume": "8",
      "author": "Martienssen",
      "year": "1989",
      "journal-title": "EMBO J."
    },
    {
      "key": "2022010519232724400_R35",
      "doi-asserted-by": "crossref",
      "first-page": "331",
      "DOI": "10.1101/gad.4.3.331",
      "article-title": "Somatically heritable switches in the DNA modification of Mu transposable elements monitored with a suppressible mutant in maize",
      "volume": "4",
      "author": "Martienssen",
      "year": "1990",
      "journal-title": "Genes Dev."
    },
    {
      "key": "2022010519232724400_R36",
      "doi-asserted-by": "crossref",
      "first-page": "5",
      "DOI": "10.1016/0300-9084(91)90067-B",
      "article-title": "Structure and function of the maize Spm transposable element",
      "volume": "73",
      "author": "Masson",
      "year": "1991",
      "journal-title": "Biochimie"
    },
    {
      "key": "2022010519232724400_R37",
      "first-page": "592",
      "article-title": "Aspects of gene regulation in maize",
      "volume": "63",
      "author": "McClintock",
      "year": "1964",
      "journal-title": "Carnegie Inst. Wash. Year Book"
    },
    {
      "key": "2022010519232724400_R38",
      "first-page": "84",
      "article-title": "Genetic systems regulating gene expression during development",
      "volume": "1",
      "author": "McClintock",
      "year": "1967",
      "journal-title": "Dev. Biol. Suppl."
    },
    {
      "key": "2022010519232724400_R39",
      "first-page": "2090",
      "article-title": "The Mu1 maize transposable element induces tissue-specific aberrant splicing and polyadenylation in two Adh1 mutants",
      "volume": "10",
      "author": "Ortiz",
      "year": "1990",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "2022010519232724400_R40",
      "doi-asserted-by": "crossref",
      "first-page": "261",
      "DOI": "10.1016/S0168-9525(99)01749-7",
      "article-title": "Suppression mechanisms: themes from variations",
      "volume": "15",
      "author": "Prelich",
      "year": "1999",
      "journal-title": "Trends Genet."
    },
    {
      "key": "2022010519232724400_R41",
      "doi-asserted-by": "crossref",
      "first-page": "845",
      "DOI": "10.1093/genetics/129.3.845",
      "article-title": "Cloning of the Mutator transposable element MuA2, a putative regulator of somatic mutability of the a1-Mum2 allele in maize",
      "volume": "129",
      "author": "Qin",
      "year": "1991",
      "journal-title": "Genetics"
    },
    {
      "key": "2022010519232724400_R42",
      "first-page": "5",
      "article-title": "The late developmental pattern of Mu transposon excision is conferred by a cauliflower mosaic virus 35S-driven MURA cDNA in transgenic maize",
      "volume": "12",
      "author": "Raizada",
      "year": "2000",
      "journal-title": "Plant Cell"
    },
    {
      "key": "2022010519232724400_R43",
      "doi-asserted-by": "crossref",
      "first-page": "21",
      "DOI": "10.1016/0027-5107(78)90004-0",
      "article-title": "Characterization of a mutator system in maize",
      "volume": "5",
      "author": "Robertson",
      "year": "1978",
      "journal-title": "Mutat. Res."
    },
    {
      "key": "2022010519232724400_R44",
      "doi-asserted-by": "crossref",
      "first-page": "482",
      "DOI": "10.1002/dvg.1020100609",
      "article-title": "Genetic analyses of putative two-element system regulating somatic mutability in mutator-induced aleurone mutants of maize",
      "volume": "10",
      "author": "Robertson",
      "year": "1989",
      "journal-title": "Dev. Genet."
    },
    {
      "key": "2022010519232724400_R45",
      "doi-asserted-by": "crossref",
      "first-page": "17",
      "DOI": "10.1007/978-1-4684-5550-2_2",
      "article-title": "Germline and somatic Mutator activity: Are they functionally related?",
      "volume-title": "Plant Transposable Elements",
      "author": "Robertson",
      "year": "1988"
    },
    {
      "key": "2022010519232724400_R46",
      "doi-asserted-by": "crossref",
      "first-page": "43",
      "DOI": "10.1007/BF00039376",
      "article-title": "Plant mRNA 3\u2032-end formation",
      "volume": "32",
      "author": "Rothnie",
      "year": "1996",
      "journal-title": "Plant Mol. Biol."
    },
    {
      "key": "2022010519232724400_R47",
      "doi-asserted-by": "crossref",
      "first-page": "8014",
      "DOI": "10.1073/pnas.81.24.8014",
      "article-title": "Ribosomal DNA spacer-length polymorphisms in barley: Mendelian inheritance, chromosomal location, and population dynamics",
      "volume": "81",
      "author": "Saghai-Maroof",
      "year": "1984",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2022010519232724400_R48",
      "first-page": "59",
      "article-title": "Distribution of genetically active Cy elements among diverse maize lines",
      "volume": "31",
      "author": "Schnable",
      "year": "1986",
      "journal-title": "Maydica"
    },
    {
      "key": "2022010519232724400_R49",
      "doi-asserted-by": "crossref",
      "first-page": "1171",
      "DOI": "10.1093/genetics/136.3.1171",
      "article-title": "Recovery of heritable, transposon-induced, mutant alleles of the rf 2 nuclear restorer of T-cytoplasm maize",
      "volume": "136",
      "author": "Schnable",
      "year": "1994",
      "journal-title": "Genetics"
    },
    {
      "key": "2022010519232724400_R50",
      "doi-asserted-by": "crossref",
      "first-page": "175",
      "DOI": "10.1016/S1360-1385(98)01235-7",
      "article-title": "The molecular basis of cytoplasmic male sterility and fertility restoration",
      "volume": "3",
      "author": "Schnable",
      "year": "1998",
      "journal-title": "Trends Plant Sci."
    },
    {
      "key": "2022010519232724400_R51",
      "doi-asserted-by": "crossref",
      "first-page": "459",
      "DOI": "10.1007/BF02464917",
      "article-title": "The bz-rcy allele of the Cy transposable element system of Zea mays contains a Mu-like element insertion",
      "volume": "217",
      "author": "Schnable",
      "year": "1989",
      "journal-title": "Mol. Gen. Genet."
    },
    {
      "key": "2022010519232724400_R52",
      "doi-asserted-by": "crossref",
      "first-page": "5799",
      "DOI": "10.1093/nar/18.19.5799",
      "article-title": "Point mutations in AAUAAA and the poly (A) addition site: effects on the accuracy and efficiency of cleavage and polyadenylation in vitro.",
      "volume": "18",
      "author": "Sheets",
      "year": "1990",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "2022010519232724400_R53",
      "doi-asserted-by": "crossref",
      "first-page": "751",
      "DOI": "10.1023/A:1014870429630",
      "article-title": "Characterization of the aldehyde dehydrogenase gene families of Zea mays and Arabidopsis",
      "volume": "48",
      "author": "Skibbe",
      "year": "2002",
      "journal-title": "Plant. Mol. Biol."
    },
    {
      "key": "2022010519232724400_R54",
      "volume-title": "Principles and Procedures of Statistics: A Biometrical Approach",
      "author": "Steel",
      "year": "1980"
    },
    {
      "key": "2022010519232724400_R55",
      "doi-asserted-by": "crossref",
      "first-page": "1247",
      "DOI": "10.1073/pnas.88.4.1247",
      "article-title": "Transposon-facilitated DNA sequencing",
      "volume": "88",
      "author": "Strathmann",
      "year": "1991",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2022010519232724400_R56",
      "doi-asserted-by": "crossref",
      "first-page": "277",
      "DOI": "10.1016/S0168-6445(99)00008-X",
      "article-title": "3\u2032-end processing of pre-mRNA in eukaryotes",
      "volume": "23",
      "author": "Wahle",
      "year": "1999",
      "journal-title": "FEMS Microbiol. Rev."
    },
    {
      "key": "2022010519232724400_R57",
      "doi-asserted-by": "crossref",
      "first-page": "1151",
      "DOI": "10.1104/pp.119.4.1151",
      "article-title": "Genes, genomes, genomics. What can plant biologists expect from the 1998 National Science Foundation Plant Genome Research Program?",
      "volume": "119",
      "author": "Walbot",
      "year": "1999",
      "journal-title": "Plant Physiol."
    },
    {
      "key": "2022010519232724400_R58",
      "doi-asserted-by": "crossref",
      "first-page": "79",
      "DOI": "10.1016/S0065-2113(08)60911-6",
      "article-title": "The genetics, pathology, and molecular biology of T-cytoplasm male sterility in maize",
      "volume": "65",
      "author": "Wise",
      "year": "1999",
      "journal-title": "Adv. Agronomy"
    },
    {
      "key": "2022010519232724400_R59",
      "doi-asserted-by": "crossref",
      "first-page": "323",
      "DOI": "10.1046/j.1365-313X.1995.08030323.x",
      "article-title": "The formation of mRNA 3\u2032-ends in plants",
      "volume": "8",
      "author": "Wu",
      "year": "1995",
      "journal-title": "Plant J."
    },
    {
      "key": "2022010519232724400_R60",
      "doi-asserted-by": "crossref",
      "first-page": "501",
      "DOI": "10.1104/pp.115.2.501",
      "article-title": "Sequence analysis of the cloned glossy8 gene of maize suggests that it may code for a beta-ketoacyl reductase required for the biosynthesis of cuticular waxes",
      "volume": "115",
      "author": "Xu",
      "year": "1997",
      "journal-title": "Plant Physiol."
    },
    {
      "key": "2022010519232724400_R61",
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      "first-page": "405",
      "DOI": "10.1128/MMBR.63.2.405-445.1999",
      "article-title": "Formation of mRNA 3\u2032 ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis",
      "volume": "63",
      "author": "Zhao",
      "year": "1999",
      "journal-title": "Microbiol. Mol. Biol. Rev."
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