DOI: 10.1093/genetics/159.2.777. Synergistic Derepression of Gibberellin Signaling by Removing RGA and GAI Function in <i>Arabidopsis thaliana</i>

Synergistic Derepression of Gibberellin Signaling by Removing RGA and GAI Function in Arabidopsis thaliana

10.1093/genetics/159.2.777

Crossref journal-article

Oxford University Press (OUP)

Genetics (286)

Abstract

Abstract RGA and GAI are negative regulators of the gibberellin (GA) signal transduction pathway in Arabidopsis thaliana. These genes may have partially redundant functions because they are highly homologous, and plants containing single null mutations at these loci are phenotypically similar to wild type. Previously, rga loss-of-function mutations were shown to partially suppress defects of the GA-deficient ga1-3 mutant. Phenotypes rescued include abaxial trichome initiation, rosette radius, flowering time, stem elongation, and apical dominance. Here we present work showing that the rga-24 and gai-t6 null mutations have a synergistic effect on plant growth. Although gai-t6 alone has little effect, when combined with rga-24, they completely rescued the above defects of ga1-3 to wild-type or GA-overdose phenotype. However, seed germination and flower development defects were not restored. Additionally, rga-24 and rga-24/gai-t6 but not gai-t6 alone caused increased feedback inhibition of expression of a GA biosynthetic gene in both the ga1-3 and wild-type backgrounds. These results demonstrate that RGA and GAI have partially redundant functions in maintaining the repressive state of the GA-signaling pathway, but RGA plays a more dominant role than GAI. Removing both RGA and GAI function allows for complete derepression of many aspects of GA signaling.

Bibliography

Dill, A., & Sun, T. (2001). Synergistic Derepression of Gibberellin Signaling by Removing RGA and GAI Function in Arabidopsis thaliana. Genetics, 159(2), 777â785.

Authors 2

Alyssa Dill (first)
Tai-ping Sun (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 28, 2021, 1:43 a.m.)
Deposited	3 years, 8 months ago (Jan. 5, 2022, 2:29 a.m.)
Indexed	1 month ago (July 30, 2025, 8:42 p.m.)
Issued	23 years, 11 months ago (Oct. 1, 2001)
Published	23 years, 11 months ago (Oct. 1, 2001)
Published Online	23 years, 11 months ago (Oct. 1, 2001)
Published Print	23 years, 11 months ago (Oct. 1, 2001)

Funders 0

None

BibTeX

@article{Dill_2001, title={Synergistic Derepression of Gibberellin Signaling by Removing RGA and GAI Function in Arabidopsis thaliana}, volume={159}, ISSN={1943-2631}, url={http://dx.doi.org/10.1093/genetics/159.2.777}, DOI={10.1093/genetics/159.2.777}, number={2}, journal={Genetics}, publisher={Oxford University Press (OUP)}, author={Dill, Alyssa and Sun, Tai-ping}, year={2001}, month=oct, pages={777–785} }

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