DOI: 10.1093/genetics/156.3.1349. <i>GL3</i> Encodes a bHLH Protein That Regulates Trichome Development in Arabidopsis Through Interaction With GL1 and TTG1

GL3 Encodes a bHLH Protein That Regulates Trichome Development in Arabidopsis Through Interaction With GL1 and TTG1

10.1093/genetics/156.3.1349

Crossref journal-article

Oxford University Press (OUP)

Genetics (286)

Abstract

Abstract Arabidopsis trichome development and differentiation is a well-studied model for plant cell-fate determination and morphogenesis. Mutations in TRANSPARENT TESTA GLABRA1 (TTG1) result in several pleiotropic defects including an almost complete lack of trichomes. The complex phenotype caused by ttg1 mutations is suppressed by ectopic expression of the maize anthocyanin regulator R. Here it is demonstrated that the Arabidopsis trichome development locus GLABRA3 (GL3) encodes an R homolog. GL3 and GLABRA1 (GL1) interact when overexpressed together in plants. Yeast two-hybrid assays indicate that GL3 participates in physical interactions with GL1, TTG1, and itself, but that GL1 and TTG1 do not interact. These data suggest a reiterated combinatorial model for the differential regulation of such diverse developmental pathways as trichome cell-fate determination, root hair spacing, and anthocyanin secondary metabolism.

Bibliography

Payne, C. T., Zhang, F., & Lloyd, A. M. (2000). GL3 Encodes a bHLH Protein That Regulates Trichome Development in Arabidopsis Through Interaction With GL1 and TTG1. Genetics, 156(3), 1349â1362.

Authors 3

C Thomas Payne (first)
Fan Zhang (additional)
Alan M Lloyd (additional)

References 53 Referenced 637

{'key': '2022010407053214400_R1', 'first-page': '1859', 'article-title': 'Role of Arabidopsis MYC and MYB homologs in drought- and abscisic acid-regulated gene expression', 'volume': '9', 'author': 'Abe', 'year': '1997', 'journal-title': 'Plant Cell'} / Plant Cell / Role of Arabidopsis MYC and MYB homologs in drought- and abscisic acid-regulated gene expression by Abe (1997)
10.1016/S1097-2765(00)80022-2 / Mol. Cell / Molecular interaction between COP1 and HY5 defines a regulatory switch for light control of Arabidopsis development by Ang (1998)
10.1073/pnas.94.10.5172 / Proc. Natl. Acad. Sci. USA / A natural classification of the basic helix-loop-helix class of transcription factors by Atchley (1997)
{'key': '2022010407053214400_R4', 'first-page': '1194', 'article-title': 'In planta Agrobacterium-mediated gene transfer by infiltration of adult Arabidopsis thaliana plants', 'volume': '316', 'author': 'Bechtold', 'year': '1993', 'journal-title': 'C. R. Acad. Sci. Ser. III Sci. Vie'} / C. R. Acad. Sci. Ser. III Sci. Vie / In planta Agrobacterium-mediated gene transfer by infiltration of adult Arabidopsis thaliana plants by Bechtold (1993)
10.1016/0092-8674(90)90214-Y / Cell / The protein Id: negative regulator of helix-loop-helix DNA binding proteins by Benezra (1990)
10.1016/0168-9525(92)90099-P / Trends Genet. / Patterning of the Drosophila nervous system: the achaete-scute gene complex by Campuzano (1992)
10.1073/pnas.83.24.9631 / Proc. Natl. Acad. Sci. USA / Molecular analysis of the maize anthocyanin regulatory locus C1 by Cone (1986)
{'key': '2022010407053214400_R8', 'first-page': '1795', 'article-title': 'Maize anthocyanin regulatory gene p1 is a duplicate of c1 that functions in the plant', 'volume': '5', 'author': 'Cone', 'year': '1993', 'journal-title': 'Plant Cell'} / Plant Cell / Maize anthocyanin regulatory gene p1 is a duplicate of c1 that functions in the plant by Cone (1993)
10.1104/pp.117.4.1195 / Plant Physiol. / Gibberellin dose-response regulation of GA4 gene transcript levels in Arabidopsis by Cowling (1998)
10.1016/0092-8674(92)90555-Q / Cell / COP1, an Arabidopsis regulatory gene, encodes a protein with both a zinc-binding motif and a Gβ homologous domain by Deng (1992)
10.1023/A:1005898823105 / Plant Mol. Biol. / RAP-1 is an Arabidopsis MYC-like R protein homologue, that binds to G-box sequence motifs by de Pater (1997)
10.1101/gad.11.11.1422 / Genes Dev. / The an11 locus controlling flower pigmentation in Petunia encodes a novel WD-repeat protein conserved in yeast, plants, and animals by de Vetten (1997)
10.1101/gad.7.4.555 / Genes Dev. / The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit by Durfee (1993)
10.1038/340245a0 / Nature / A novel genetic system to detect protein-protein interaction by Fields (1989)
10.1006/dbio.1994.1352 / Dev. Biol. / The TTG gene is required to specify epidermal cell fate and cell patterning in the Arabidopsis root by Galway (1994)
10.1016/0092-8674(90)90213-X / Cell / The Drosophila extramacrochaetae locus, an antagonist of proneural genes that, like these genes, encodes a helix-loop-helix protein by Garrell (1990)
10.1101/gad.6.5.864 / Genes Dev. / Functional analysis of the transcriptional activator encoded by the maize B gene: evidence for a direct functional interaction between two classes of regulatory proteins by Goff (1992)
10.1016/0092-8674(92)90038-E / Cell / A common gene regulates pigmentation pattern in diverse plant species by Goodrich (1992)
10.2307/3869022 / Plant Cell / Trichome development in Arabidopsis thaliana. II. Isolation and complementation of the GLABROUS1 gene by Herman (1989)
10.1016/0092-8674(94)90118-X / Cell / Genetic dissection of trichome cell development in Arabidopsis by Hülskamp (1994)
10.1007/BF00331014 / Mol. Gen. Genet. / The promoter TL-DNA gene 5 controls the tissue-specific expression of chimaeric genes carried by a novel type of Agrobacterium binary vector by Koncz (1986)
{'key': '2022010407053214400_R22', 'first-page': '45', 'article-title': 'The complex syndrome of ttg mutants', 'volume': '18', 'author': 'Koornneef', 'year': '1981', 'journal-title': 'Arabidopsis Inf. Serv.'} / Arabidopsis Inf. Serv. / The complex syndrome of ttg mutants by Koornneef (1981)
10.1016/0027-5107(82)90129-4 / Heynh. Mutat. Res. / EMS- and radiation-induced mutation frequencies at individual loci in Arabidopsis thaliana (L.) by Koornneef (1982)
10.1093/oxfordjournals.jhered.a109781 / J. Hered. / Linkage map of Arabidopsis thaliana. by Koornneef (1983)
10.2307/3869885 / Plant Cell / Roles of the GLABROUS1 and TRANSPARENT TESTA GLABRA genes in Arabidopsis trichome development by Larkin (1994)
10.1242/dev.122.3.997 / Development / The control of trichome spacing and number in Arabidopsis by Larkin (1996)
{'key': '2022010407053214400_R27', 'first-page': '4', 'article-title': 'Toward the cloning of GL3', 'volume-title': 'Proceedings of the 9th International Conference on Arabidopsis Research', 'author': 'Larkin', 'year': '1998'} / Proceedings of the 9th International Conference on Arabidopsis Research / Toward the cloning of GL3 by Larkin (1998)
10.1093/genetics/151.4.1591 / Genetics / Allele-specific interactions between ttg and gl1 during trichome development in Arabidopsis thaliana by Larkin (1999)
10.1093/genetics/150.4.1639 / Genetics / Molecular consequences of Ds insertion into and excision from the helixloop-helix domain of the maize R gene by Liu (1998)
10.1007/BF00283419 / Mol. Gen. Genet. / Functional expression of the yeast FLP/FRT site-specific recombination system in Nicotiana tabacum. by Lloyd (1994)
10.1126/science.1465611 / Science / Arabidopsis and Nicotiana anthocyanin production activated by maize regulators R and C1 by Lloyd (1992)
10.1073/pnas.86.18.7092 / Proc. Natl. Acad. Sci. USA / Lc, a member of the maize R gene family responsible for tissue-specific anthocyanin production, encodes a protein similar to transcriptional activators and contains the myc-homology region by Ludwig (1989)
10.1007/BF00285451 / Mol. Gen. Genet. / The FUSCA genes of Arabidopsis: negative regulators of light responses by Miséra (1994)
10.1016/0378-1119(94)90098-1 / Gene / The adenine phosphoribosyltransferase-encoding gene of Arabidopsis thaliana by Moffatt (1994)
10.1038/371297a0 / Nature / The ancient regulatory protein family of WD-repeat proteins by Neer (1994)
10.1101/gad.12.19.3059 / Genes Dev. / Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD protein, in Arabidopsis by Németh (1998)
10.1016/0092-8674(91)90523-2 / Cell / A myb gene required for leaf trichome differentiation in Arabidopsis is expressed in stipules by Oppenheimer (1991)
10.1242/dev.126.4.671 / Development / Heterologous myb genes distinct from GL1 enhance trichome production when overexpressed in Nicotiana tabacum. by Payne (1999)
10.1002/j.1460-2075.1987.tb02684.x / EMBO J. / The regulatory c1 locus of Zea mays encodes a protein with homology to myb proto-oncogene products and with structural similarities to transcriptional activators by Paz-Ares (1987)
{'key': '2022010407053214400_R40', 'first-page': '315', 'article-title': 'Molecular analysis of the C1-I allele from Zea mays: a dominant mutant of the regulatory C1 locus', 'volume': '2', 'author': 'Paz-Ares', 'year': '1994', 'journal-title': 'EMBO J.'} / EMBO J. / Molecular analysis of the C1-I allele from Zea mays: a dominant mutant of the regulatory C1 locus by Paz-Ares (1994)
10.1046/j.1365-313X.1998.00046.x / Plant J. / Analysis of bHLH and MYB domain proteins: species-specific regulatory differences are caused by divergent evolution of target anthocyanin genes by Quattrocchio (1998)
10.1016/0378-1119(87)90359-3 / Gene / Design and construction of a versatile system for the expression of foreign genes in plants by Schardl (1987)
10.1105/tpc.11.6.1105 / Plant Cell / Generation of a spacing pattern: the role of TRIPTYCHON in trichome patterning in Arabidopsis by Schnittger (1999)
10.1104/pp.101.2.353 / Plant Physiol. / Nuclear targeting of the maize R protein requires two nuclear localization sequences by Shieh (1993)
10.1016/S0968-0004(99)01384-5 / Trends Biochem. Sci. / The WD repeat: a common architecture for diverse functions by Smith (1999)
10.1038/379369a0 / Nature / Crystal structure of G-protein-dimer at 2.1 angstrom resolution by Sondek (1996)
10.1242/dev.125.7.1161 / Development / Control of GL2 expression in Arabidopsis leaves and trichomes by Szymanski (1998)
10.1016/S1360-1385(00)01597-1 / Trends Plant Sci. / Progress in the molecular genetic analysis of trichome initiation and morphogenesis in Arabidopsis. by Szymanski (2000)
10.1105/tpc.10.2.135 / Plant Cell / The AmMYB308 and AmMYB330 transcription factors from Antirrhinum regulate phenylpropanoid and lignin biosynthesis in transgenic tobacco by Tamagnone (1998)
10.1093/emboj/17.19.5577 / EMBO J. / Functional dissection of Arabidopsis COP1 reveals specific roles of its three structural modules in light control of seedling development by Torii (1998)
10.1007/BF00019112 / Plant Mol. Biol. / Molecular cloning and characterization of a gene that encodes a MYC-related protein in Arabidopsis by Urao (1996)
10.1126/science.277.5329.1113 / Science / Epidermal cell differentiation in Arabidopsis determined by a Myb homolog, CPC by Wada (1997)
10.1105/tpc.11.7.1337 / Plant Cell / The TRANSPARENT TESTA GLABRA1 locus, which regulates trichome differentiation and anthocyanin biosynthesis in Arabidopsis, encodes a WD40 repeat protein by Walker (1999)

Dates

Type	When
Created	4 years, 4 months ago (April 28, 2021, 1:28 a.m.)
Deposited	3 years, 7 months ago (Jan. 4, 2022, 2:36 a.m.)
Indexed	20 hours, 52 minutes ago (Aug. 29, 2025, 6:49 a.m.)
Issued	24 years, 9 months ago (Nov. 1, 2000)
Published	24 years, 9 months ago (Nov. 1, 2000)
Published Online	24 years, 9 months ago (Nov. 1, 2000)
Published Print	24 years, 9 months ago (Nov. 1, 2000)

Funders 0

None

BibTeX

@article{Payne_2000, title={GL3 Encodes a bHLH Protein That Regulates Trichome Development in Arabidopsis Through Interaction With GL1 and TTG1}, volume={156}, ISSN={1943-2631}, url={http://dx.doi.org/10.1093/genetics/156.3.1349}, DOI={10.1093/genetics/156.3.1349}, number={3}, journal={Genetics}, publisher={Oxford University Press (OUP)}, author={Payne, C Thomas and Zhang, Fan and Lloyd, Alan M}, year={2000}, month=nov, pages={1349–1362} }

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      "article-title": "A natural classification of the basic helix-loop-helix class of transcription factors",
      "volume": "94",
      "author": "Atchley",
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      "journal-title": "Proc. Natl. Acad. Sci. USA"
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      "article-title": "In planta Agrobacterium-mediated gene transfer by infiltration of adult Arabidopsis thaliana plants",
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      "journal-title": "Cell"
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      "author": "Campuzano",
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      "journal-title": "Trends Genet."
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      "first-page": "9631",
      "DOI": "10.1073/pnas.83.24.9631",
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      "volume": "83",
      "author": "Cone",
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    },
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      "key": "2022010407053214400_R8",
      "first-page": "1795",
      "article-title": "Maize anthocyanin regulatory gene p1 is a duplicate of c1 that functions in the plant",
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      "first-page": "997",
      "DOI": "10.1242/dev.122.3.997",
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      "author": "Larkin",
      "year": "1996",
      "journal-title": "Development"
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      "key": "2022010407053214400_R27",
      "first-page": "4",
      "article-title": "Toward the cloning of GL3",
      "volume-title": "Proceedings of the 9th International Conference on Arabidopsis Research",
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      "key": "2022010407053214400_R28",
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      "first-page": "1591",
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      "article-title": "Allele-specific interactions between ttg and gl1 during trichome development in Arabidopsis thaliana",
      "volume": "151",
      "author": "Larkin",
      "year": "1999",
      "journal-title": "Genetics"
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      "first-page": "1639",
      "DOI": "10.1093/genetics/150.4.1639",
      "article-title": "Molecular consequences of Ds insertion into and excision from the helixloop-helix domain of the maize R gene",
      "volume": "150",
      "author": "Liu",
      "year": "1998",
      "journal-title": "Genetics"
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      "key": "2022010407053214400_R30",
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      "first-page": "653",
      "DOI": "10.1007/BF00283419",
      "article-title": "Functional expression of the yeast FLP/FRT site-specific recombination system in Nicotiana tabacum.",
      "volume": "242",
      "author": "Lloyd",
      "year": "1994",
      "journal-title": "Mol. Gen. Genet."
    },
    {
      "key": "2022010407053214400_R31",
      "doi-asserted-by": "crossref",
      "first-page": "1773",
      "DOI": "10.1126/science.1465611",
      "article-title": "Arabidopsis and Nicotiana anthocyanin production activated by maize regulators R and C1",
      "volume": "258",
      "author": "Lloyd",
      "year": "1992",
      "journal-title": "Science"
    },
    {
      "key": "2022010407053214400_R32",
      "doi-asserted-by": "crossref",
      "first-page": "7092",
      "DOI": "10.1073/pnas.86.18.7092",
      "article-title": "Lc, a member of the maize R gene family responsible for tissue-specific anthocyanin production, encodes a protein similar to transcriptional activators and contains the myc-homology region",
      "volume": "86",
      "author": "Ludwig",
      "year": "1989",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2022010407053214400_R33",
      "doi-asserted-by": "crossref",
      "first-page": "242",
      "DOI": "10.1007/BF00285451",
      "article-title": "The FUSCA genes of Arabidopsis: negative regulators of light responses",
      "volume": "244",
      "author": "Mis\u00e9ra",
      "year": "1994",
      "journal-title": "Mol. Gen. Genet."
    },
    {
      "key": "2022010407053214400_R34",
      "doi-asserted-by": "crossref",
      "first-page": "211",
      "DOI": "10.1016/0378-1119(94)90098-1",
      "article-title": "The adenine phosphoribosyltransferase-encoding gene of Arabidopsis thaliana",
      "volume": "143",
      "author": "Moffatt",
      "year": "1994",
      "journal-title": "Gene"
    },
    {
      "key": "2022010407053214400_R35",
      "doi-asserted-by": "crossref",
      "first-page": "297",
      "DOI": "10.1038/371297a0",
      "article-title": "The ancient regulatory protein family of WD-repeat proteins",
      "volume": "373",
      "author": "Neer",
      "year": "1994",
      "journal-title": "Nature"
    },
    {
      "key": "2022010407053214400_R36",
      "doi-asserted-by": "crossref",
      "first-page": "3059",
      "DOI": "10.1101/gad.12.19.3059",
      "article-title": "Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD protein, in Arabidopsis",
      "volume": "12",
      "author": "N\u00e9meth",
      "year": "1998",
      "journal-title": "Genes Dev."
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    {
      "key": "2022010407053214400_R37",
      "doi-asserted-by": "crossref",
      "first-page": "483",
      "DOI": "10.1016/0092-8674(91)90523-2",
      "article-title": "A myb gene required for leaf trichome differentiation in Arabidopsis is expressed in stipules",
      "volume": "67",
      "author": "Oppenheimer",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "2022010407053214400_R38",
      "doi-asserted-by": "crossref",
      "first-page": "671",
      "DOI": "10.1242/dev.126.4.671",
      "article-title": "Heterologous myb genes distinct from GL1 enhance trichome production when overexpressed in Nicotiana tabacum.",
      "volume": "126",
      "author": "Payne",
      "year": "1999",
      "journal-title": "Development"
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    {
      "key": "2022010407053214400_R39",
      "doi-asserted-by": "crossref",
      "first-page": "3553",
      "DOI": "10.1002/j.1460-2075.1987.tb02684.x",
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      "volume": "6",
      "author": "Paz-Ares",
      "year": "1987",
      "journal-title": "EMBO J."
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    {
      "key": "2022010407053214400_R40",
      "first-page": "315",
      "article-title": "Molecular analysis of the C1-I allele from Zea mays: a dominant mutant of the regulatory C1 locus",
      "volume": "2",
      "author": "Paz-Ares",
      "year": "1994",
      "journal-title": "EMBO J."
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    {
      "key": "2022010407053214400_R41",
      "doi-asserted-by": "crossref",
      "first-page": "475",
      "DOI": "10.1046/j.1365-313X.1998.00046.x",
      "article-title": "Analysis of bHLH and MYB domain proteins: species-specific regulatory differences are caused by divergent evolution of target anthocyanin genes",
      "volume": "13",
      "author": "Quattrocchio",
      "year": "1998",
      "journal-title": "Plant J."
    },
    {
      "key": "2022010407053214400_R42",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1016/0378-1119(87)90359-3",
      "article-title": "Design and construction of a versatile system for the expression of foreign genes in plants",
      "volume": "61",
      "author": "Schardl",
      "year": "1987",
      "journal-title": "Gene"
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    {
      "key": "2022010407053214400_R43",
      "doi-asserted-by": "crossref",
      "first-page": "1105",
      "DOI": "10.1105/tpc.11.6.1105",
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      "volume": "11",
      "author": "Schnittger",
      "year": "1999",
      "journal-title": "Plant Cell"
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    {
      "key": "2022010407053214400_R44",
      "doi-asserted-by": "crossref",
      "first-page": "353",
      "DOI": "10.1104/pp.101.2.353",
      "article-title": "Nuclear targeting of the maize R protein requires two nuclear localization sequences",
      "volume": "101",
      "author": "Shieh",
      "year": "1993",
      "journal-title": "Plant Physiol."
    },
    {
      "key": "2022010407053214400_R45",
      "doi-asserted-by": "crossref",
      "first-page": "181",
      "DOI": "10.1016/S0968-0004(99)01384-5",
      "article-title": "The WD repeat: a common architecture for diverse functions",
      "volume": "24",
      "author": "Smith",
      "year": "1999",
      "journal-title": "Trends Biochem. Sci."
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    {
      "key": "2022010407053214400_R46",
      "doi-asserted-by": "crossref",
      "first-page": "369",
      "DOI": "10.1038/379369a0",
      "article-title": "Crystal structure of G-protein-dimer at 2.1 angstrom resolution",
      "volume": "379",
      "author": "Sondek",
      "year": "1996",
      "journal-title": "Nature"
    },
    {
      "key": "2022010407053214400_R47",
      "doi-asserted-by": "crossref",
      "first-page": "1161",
      "DOI": "10.1242/dev.125.7.1161",
      "article-title": "Control of GL2 expression in Arabidopsis leaves and trichomes",
      "volume": "125",
      "author": "Szymanski",
      "year": "1998",
      "journal-title": "Development"
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    {
      "key": "2022010407053214400_R48",
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      "first-page": "214",
      "DOI": "10.1016/S1360-1385(00)01597-1",
      "article-title": "Progress in the molecular genetic analysis of trichome initiation and morphogenesis in Arabidopsis.",
      "volume": "5",
      "author": "Szymanski",
      "year": "2000",
      "journal-title": "Trends Plant Sci."
    },
    {
      "key": "2022010407053214400_R49",
      "doi-asserted-by": "crossref",
      "first-page": "135",
      "DOI": "10.1105/tpc.10.2.135",
      "article-title": "The AmMYB308 and AmMYB330 transcription factors from Antirrhinum regulate phenylpropanoid and lignin biosynthesis in transgenic tobacco",
      "volume": "10",
      "author": "Tamagnone",
      "year": "1998",
      "journal-title": "Plant Cell"
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    {
      "key": "2022010407053214400_R50",
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      "first-page": "5577",
      "DOI": "10.1093/emboj/17.19.5577",
      "article-title": "Functional dissection of Arabidopsis COP1 reveals specific roles of its three structural modules in light control of seedling development",
      "volume": "17",
      "author": "Torii",
      "year": "1998",
      "journal-title": "EMBO J."
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    {
      "key": "2022010407053214400_R51",
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      "first-page": "571",
      "DOI": "10.1007/BF00019112",
      "article-title": "Molecular cloning and characterization of a gene that encodes a MYC-related protein in Arabidopsis",
      "volume": "32",
      "author": "Urao",
      "year": "1996",
      "journal-title": "Plant Mol. Biol."
    },
    {
      "key": "2022010407053214400_R52",
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      "first-page": "1113",
      "DOI": "10.1126/science.277.5329.1113",
      "article-title": "Epidermal cell differentiation in Arabidopsis determined by a Myb homolog, CPC",
      "volume": "277",
      "author": "Wada",
      "year": "1997",
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    {
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      "first-page": "1337",
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      "volume": "11",
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