DOI: 10.1093/genetics/155.2.551. Four Chromo-domain Proteins of <i>Schizosaccharomyces pombe</i> Differentially Repress Transcription at Various Chromosomal Locations

Four Chromo-domain Proteins of Schizosaccharomyces pombe Differentially Repress Transcription at Various Chromosomal Locations

10.1093/genetics/155.2.551

Crossref journal-article

Oxford University Press (OUP)

Genetics (286)

Abstract

Abstract Transcription is repressed in regions of the fission yeast genome close to centromeres, telomeres, or the silent mating-type cassettes mat2-P and mat3-M. The repression involves the chromo-domain proteins Swi6 and Clr4. We report that two other chromo-domain proteins, Chp1 and Chp2, are also important for these position effects. Chp1 showed a specificity for centromeric regions. Its essentiality for the transcriptional repression of centromeric markers correlates with its importance for chromosome stability. Chp2 appeared more pleiotropic. Its effects on centromeric silencing were less pronounced than those of Chp1, and it participated in telomeric position effects and transcriptional silencing in the mating-type region. We also found that PolII-transcribed genes were repressed when placed in one of the Schizosaccharomyces pombe rDNA clusters, a situation analogous to that in the budding yeast Saccharomyces cerevisiae. Chp2, Swi6, Clr4, and, to a lesser extent, Chp1 participated in that repression.

Bibliography

Thon, G., & Verhein-Hansen, J. (2000). Four Chromo-domain Proteins of Schizosaccharomyces pombe Differentially Repress Transcription at Various Chromosomal Locations. Genetics, 155(2), 551â568.

Authors 2

Geneviève Thon (first)
Janne Verhein-Hansen (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 27, 2021, 11:36 p.m.)
Deposited	3 years, 7 months ago (Jan. 4, 2022, 1:52 a.m.)
Indexed	1 month ago (July 28, 2025, 2:49 a.m.)
Issued	25 years, 3 months ago (June 1, 2000)
Published	25 years, 3 months ago (June 1, 2000)
Published Online	25 years, 3 months ago (June 1, 2000)
Published Print	25 years, 3 months ago (June 1, 2000)

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BibTeX

@article{Thon_2000, title={Four Chromo-domain Proteins of Schizosaccharomyces pombe Differentially Repress Transcription at Various Chromosomal Locations}, volume={155}, ISSN={1943-2631}, url={http://dx.doi.org/10.1093/genetics/155.2.551}, DOI={10.1093/genetics/155.2.551}, number={2}, journal={Genetics}, publisher={Oxford University Press (OUP)}, author={Thon, Geneviève and Verhein-Hansen, Janne}, year={2000}, month=jun, pages={551–568} }

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