DOI: 10.1093/genetics/153.1.415. Meiotic Drive of Chromosomal Knobs Reshaped the Maize Genome

Meiotic Drive of Chromosomal Knobs Reshaped the Maize Genome

10.1093/genetics/153.1.415

Crossref journal-article

Oxford University Press (OUP)

Genetics (286)

Abstract

Abstract Meiotic drive is the subversion of meiosis so that particular genes are preferentially transmitted to the progeny. Meiotic drive generally causes the preferential segregation of small regions of the genome; however, in maize we propose that meiotic drive is responsible for the evolution of large repetitive DNA arrays on all chromosomes. A maize meiotic drive locus found on an uncommon form of chromosome 10 [abnormal 10 (Ab10)] may be largely responsible for the evolution of heterochromatic chromosomal knobs, which can confer meiotic drive potential to every maize chromosome. Simulations were used to illustrate the dynamics of this meiotic drive model and suggest knobs might be deleterious in the absence of Ab10. Chromosomal knob data from maize's wild relatives (Zea mays ssp. parviglumis and mexicana) and phylogenetic comparisons demonstrated that the evolution of knob size, frequency, and chromosomal position agreed with the meiotic drive hypothesis. Knob chromosomal position was incompatible with the hypothesis that knob repetitive DNA is neutral or slightly deleterious to the genome. We also show that environmental factors and transposition may play a role in the evolution of knobs. Because knobs occur at multiple locations on all maize chromosomes, the combined effects of meiotic drive and genetic linkage may have reshaped genetic diversity throughout the maize genome in response to the presence of Ab10. Meiotic drive may be a major force of genome evolution, allowing revolutionary changes in genome structure and diversity over short evolutionary periods.

Bibliography

Buckler, E. S., Phelps-Durr, T. L., Buckler, C. S. K., Dawe, R. K., Doebley, J. F., & Holtsford, T. P. (1999). Meiotic Drive of Chromosomal Knobs Reshaped the Maize Genome. Genetics, 153(1), 415â426.

Authors 6

Edward S Buckler (first)
Tara L Phelps-Durr (additional)
Carlyn S Keith Buckler (additional)
R Kelly Dawe (additional)
John F Doebley (additional)
Timothy P Holtsford (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 27, 2021, 11:11 p.m.)
Deposited	3 years, 7 months ago (Jan. 3, 2022, 10:45 p.m.)
Indexed	3 days, 5 hours ago (Aug. 30, 2025, 1:15 p.m.)
Issued	26 years ago (Sept. 1, 1999)
Published	26 years ago (Sept. 1, 1999)
Published Online	26 years ago (Sept. 1, 1999)
Published Print	26 years ago (Sept. 1, 1999)

Funders 0

None

BibTeX

@article{Buckler_1999, title={Meiotic Drive of Chromosomal Knobs Reshaped the Maize Genome}, volume={153}, ISSN={1943-2631}, url={http://dx.doi.org/10.1093/genetics/153.1.415}, DOI={10.1093/genetics/153.1.415}, number={1}, journal={Genetics}, publisher={Oxford University Press (OUP)}, author={Buckler, Edward S and Phelps-Durr, Tara L and Buckler, Carlyn S Keith and Dawe, R Kelly and Doebley, John F and Holtsford, Timothy P}, year={1999}, month=sep, pages={415–426} }

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