DOI: 10.1093/genetics/152.3.985. Mutations Affecting Symmetrical Migration of Distal Tip Cells in Caenorhabditis elegans

Mutations Affecting Symmetrical Migration of Distal Tip Cells in Caenorhabditis elegans

10.1093/genetics/152.3.985

Crossref journal-article

Oxford University Press (OUP)

Genetics (286)

Abstract

Abstract The rotational symmetry of the Caenorhabditis elegans gonad arms is generated by the symmetrical migration of two distal tip cells (DTCs), located on the anterior and posterior ends of the gonad primordium. Mutations that cause asymmetrical migration of the two DTCs were isolated. All seven mutations were recessive and assigned to six different complementation groups. vab-3(k121) and vab-3(k143) affected anterior DTC migration more frequently than posterior, although null mutants showed no bias. The other five mutations, mig-14(k124), mig-17(k113), mig-18(k140), mig-19(k142), and mig-20(k148), affected posterior DTC migration more frequently than anterior. These observations imply that the migration of each DTC is regulated differently. mig-14 and mig-19 also affected the migration of other cells in the posterior body region. Four distinct types of DTC migration abnormalities were defined on the basis of the mutant phenotypes. vab-3; mig-14 double mutants exhibited the types of DTC migration defects seen for vab-3 single mutants. Combination of mig-17 and mig-18 or mig-19, which are characterized by the same types of posterior DTC migration defects, exhibited strong enhancement of anterior DTC migration defects, suggesting that they affect the same or parallel pathways regulating anterior DTC migration.

Bibliography

Nishiwaki, K. (1999). Mutations Affecting Symmetrical Migration of Distal Tip Cells in Caenorhabditis elegans. Genetics, 152(3), 985â997.

Authors 1

Kiyoji Nishiwaki (first)

References 37 Referenced 75

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Dates

Type	When
Created	4 years, 4 months ago (April 27, 2021, 10:51 p.m.)
Deposited	3 years, 8 months ago (Jan. 3, 2022, 12:32 p.m.)
Indexed	1 month, 1 week ago (July 28, 2025, 5:25 p.m.)
Issued	26 years, 2 months ago (July 1, 1999)
Published	26 years, 2 months ago (July 1, 1999)
Published Online	26 years, 2 months ago (July 1, 1999)
Published Print	26 years, 2 months ago (July 1, 1999)

Funders 0

None

BibTeX

@article{Nishiwaki_1999, title={Mutations Affecting Symmetrical Migration of Distal Tip Cells in Caenorhabditis elegans}, volume={152}, ISSN={1943-2631}, url={http://dx.doi.org/10.1093/genetics/152.3.985}, DOI={10.1093/genetics/152.3.985}, number={3}, journal={Genetics}, publisher={Oxford University Press (OUP)}, author={Nishiwaki, Kiyoji}, year={1999}, month=jul, pages={985–997} }

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