DOI: 10.1093/genetics/150.1.449. The Population Genetics of Synthetic Lethals

The Population Genetics of Synthetic Lethals

10.1093/genetics/150.1.449

Crossref journal-article

Oxford University Press (OUP)

Genetics (286)

Abstract

Abstract Synthetic lethals are variants at different loci that have little or no effect on viability singly but cause lethality in combination. The importance of synthetic lethals and, more generally, of synthetic deleterious loci (SDL) has been controversial. Here, we derive the expected frequencies for SDL under a mutation-selection balance for the complete haploid model and selected cases of the diploid model. We have also obtained simple approximations that demonstrate good fit to exact solutions based on numerical iterations. In the haploid case, equilibrium frequencies of carrier haplotypes (individuals with only a single mutation) are comparable to analogous single-locus results, after allowing for the effects of linkage. Frequencies in the diploid case, however, are much higher and more comparable to the square root of the single-locus results. In particular, when selection operates only on the double-mutant homozygote and linkage is not too tight, the expected frequency of the carriers is approximately the quartic root of the ratio between the mutation rate and the selection coefficient of the synthetics. For a reasonably wide set of models, the frequencies of carriers can be on the order of a few percent. The equilibrium frequencies of these deleterious alleles can be relatively high because, with SDL, both dominance and epistasis act to shield carriers from exposure to selection. We also discuss the possible role of SDL in maintaining genetic variation and in hybrid breakdown.

Bibliography

Phillips, P. C., & Johnson, N. A. (1998). The Population Genetics of Synthetic Lethals. Genetics, 150(1), 449â458.

Authors 2

Patrick C Phillips (first)
Norman A Johnson (additional)

References 46 Referenced 41

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Dates

Type	When
Created	4 years, 4 months ago (April 27, 2021, 10:11 p.m.)
Deposited	3 years, 8 months ago (Jan. 3, 2022, 7:36 a.m.)
Indexed	1 year, 1 month ago (Aug. 4, 2024, 3:15 a.m.)
Issued	27 years ago (Sept. 1, 1998)
Published	27 years ago (Sept. 1, 1998)
Published Online	27 years ago (Sept. 1, 1998)
Published Print	27 years ago (Sept. 1, 1998)

Funders 0

None

BibTeX

@article{Phillips_1998, title={The Population Genetics of Synthetic Lethals}, volume={150}, ISSN={1943-2631}, url={http://dx.doi.org/10.1093/genetics/150.1.449}, DOI={10.1093/genetics/150.1.449}, number={1}, journal={Genetics}, publisher={Oxford University Press (OUP)}, author={Phillips, Patrick C and Johnson, Norman A}, year={1998}, month=sep, pages={449–458} }

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