DOI: 10.1093/genetics/141.4.1399. The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.

The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.

10.1093/genetics/141.4.1399

Crossref journal-article

Oxford University Press (OUP)

Genetics (286)

Abstract

Abstract Recessive mutations in two genes, daf-2 and age-1, extend the lifespan of Caenorhabditis elegans significantly. The daf-2 gene also regulates formation of an alternative developmental state called the dauer. Here we asked whether these two genes function in the same or different lifespan pathways. We found that the longevity of both age-1 and daf-2 mutants requires the activities of the same two genes, daf-16 and daf-18. In addition, the daf-2(e1370); age-1(hx546) double mutant did not live significantly longer than the daf-2 single mutant. We also found that, like daf-2 mutations, the age-1(hx546) mutation affects certain aspects of dauer formation. These findings suggest that age-1 and daf-2 mutations do act in the same lifespan pathway and extend lifespan by triggering similar if not identical processes.

Bibliography

Dorman, J. B., Albinder, B., Shroyer, T., & Kenyon, C. (1995). The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics, 141(4), 1399â1406.

Authors 4

J B Dorman (first)
B Albinder (additional)
T Shroyer (additional)
C Kenyon (additional)

References 0 Referenced 343

None

Dates

Type	When
Created	4 years, 7 months ago (Jan. 13, 2021, 4:27 p.m.)
Deposited	4 years, 4 months ago (April 22, 2021, 4:41 p.m.)
Indexed	1 week, 3 days ago (Aug. 23, 2025, 1:22 a.m.)
Issued	29 years, 9 months ago (Dec. 1, 1995)
Published	29 years, 9 months ago (Dec. 1, 1995)
Published Online	29 years, 9 months ago (Dec. 1, 1995)
Published Print	29 years, 9 months ago (Dec. 1, 1995)

Funders 0

None

BibTeX

@article{Dorman_1995, title={The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.}, volume={141}, ISSN={1943-2631}, url={http://dx.doi.org/10.1093/genetics/141.4.1399}, DOI={10.1093/genetics/141.4.1399}, number={4}, journal={Genetics}, publisher={Oxford University Press (OUP)}, author={Dorman, J B and Albinder, B and Shroyer, T and Kenyon, C}, year={1995}, month=dec, pages={1399–1406} }

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