DOI: 10.1093/genetics/139.3.1421. A nonparametric approach for mapping quantitative trait loci.

A nonparametric approach for mapping quantitative trait loci.

10.1093/genetics/139.3.1421

Crossref journal-article

Oxford University Press (OUP)

Genetics (286)

Abstract

Abstract Genetic mapping of quantitative trait loci (QTLs) is performed typically by using a parametric approach, based on the assumption that the phenotype follows a normal distribution. Many traits of interest, however, are not normally distributed. In this paper, we present a nonparametric approach to QTL mapping applicable to any phenotypic distribution. The method is based on a statistic ZW, which generalizes the nonparametric Wilcoxon rank-sum test to the situation of whole-genome search by interval mapping. We determine the appropriate significance level for the statistic ZW, by showing that its asymptotic null distribution follows an Ornstein-Uhlenbeck process. These results provide a robust, distribution-free method for mapping QTLs.

Bibliography

Kruglyak, L., & Lander, E. S. (1995). A nonparametric approach for mapping quantitative trait loci. Genetics, 139(3), 1421â1428.

Authors 2

L Kruglyak (first)
E S Lander (additional)

References 0 Referenced 225

None

Dates

Type	When
Created	4 years, 7 months ago (Jan. 13, 2021, 4:12 p.m.)
Deposited	4 years, 4 months ago (April 22, 2021, 3:33 p.m.)
Indexed	2 days, 19 hours ago (Sept. 3, 2025, 6:01 a.m.)
Issued	30 years, 6 months ago (March 1, 1995)
Published	30 years, 6 months ago (March 1, 1995)
Published Online	30 years, 6 months ago (March 1, 1995)
Published Print	30 years, 6 months ago (March 1, 1995)

Funders 0

None

BibTeX

@article{Kruglyak_1995, title={A nonparametric approach for mapping quantitative trait loci.}, volume={139}, ISSN={1943-2631}, url={http://dx.doi.org/10.1093/genetics/139.3.1421}, DOI={10.1093/genetics/139.3.1421}, number={3}, journal={Genetics}, publisher={Oxford University Press (OUP)}, author={Kruglyak, L and Lander, E S}, year={1995}, month=mar, pages={1421–1428} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        9,
        3
      ]
    ],
    "date-time": "2025-09-03T10:01:46Z",
    "timestamp": 1756893706854
  },
  "reference-count": 0,
  "publisher": "Oxford University Press (OUP)",
  "issue": "3",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1995,
            3,
            1
          ]
        ],
        "date-time": "1995-03-01T00:00:00Z",
        "timestamp": 794016000000
      },
      "content-version": "vor",
      "delay-in-days": 0,
      "URL": "https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1995,
        3,
        1
      ]
    ]
  },
  "abstract": "<jats:title>Abstract</jats:title>\n               <jats:p>Genetic mapping of quantitative trait loci (QTLs) is performed typically by using a parametric approach, based on the assumption that the phenotype follows a normal distribution. Many traits of interest, however, are not normally distributed. In this paper, we present a nonparametric approach to QTL mapping applicable to any phenotypic distribution. The method is based on a statistic ZW, which generalizes the nonparametric Wilcoxon rank-sum test to the situation of whole-genome search by interval mapping. We determine the appropriate significance level for the statistic ZW, by showing that its asymptotic null distribution follows an Ornstein-Uhlenbeck process. These results provide a robust, distribution-free method for mapping QTLs.</jats:p>",
  "DOI": "10.1093/genetics/139.3.1421",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2021,
        1,
        13
      ]
    ],
    "date-time": "2021-01-13T21:12:22Z",
    "timestamp": 1610572342000
  },
  "page": "1421-1428",
  "source": "Crossref",
  "is-referenced-by-count": 225,
  "title": "A nonparametric approach for mapping quantitative trait loci.",
  "prefix": "10.1093",
  "volume": "139",
  "author": [
    {
      "given": "L",
      "family": "Kruglyak",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "E S",
      "family": "Lander",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "286",
  "published-online": {
    "date-parts": [
      [
        1995,
        3,
        1
      ]
    ]
  },
  "container-title": "Genetics",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://academic.oup.com/genetics/article-pdf/139/3/1421/34604531/genetics1421.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "syndication"
    },
    {
      "URL": "http://academic.oup.com/genetics/article-pdf/139/3/1421/34604531/genetics1421.pdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        4,
        22
      ]
    ],
    "date-time": "2021-04-22T19:33:38Z",
    "timestamp": 1619120018000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://academic.oup.com/genetics/article/139/3/1421/6013111"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1995,
        3,
        1
      ]
    ]
  },
  "references-count": 0,
  "journal-issue": {
    "issue": "3",
    "published-print": {
      "date-parts": [
        [
          1995,
          3,
          1
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1093/genetics/139.3.1421",
  "relation": {},
  "ISSN": [
    "1943-2631"
  ],
  "subject": [],
  "published-other": {
    "date-parts": [
      [
        1995,
        3,
        1
      ]
    ]
  },
  "published": {
    "date-parts": [
      [
        1995,
        3,
        1
      ]
    ]
  }
}