DOI: 10.1093/genetics/128.1.79. Isolation of mutants defective in early steps of meiotic recombination in the yeast Saccharomyces cerevisiae.

Isolation of mutants defective in early steps of meiotic recombination in the yeast Saccharomyces cerevisiae.

10.1093/genetics/128.1.79

Crossref journal-article

Oxford University Press (OUP)

Genetics (286)

Abstract

Abstract Using a selection based upon the ability of early Rec- mutations (e.g., rad50) to rescue the meiotic lethality of a rad52 spo13 strain, we have isolated 177 mutants. Analysis of 56 of these has generated alleles of the known Rec genes SPO11, ME14 and MER1, as well as defining five new genes: REC102, REC104, REC107, REC113 and REC114. Mutations in all of the new genes appear to specifically affect meiosis; they do not have any detectable mitotic phenotype. Mutations in REC102, REC104 and REC107 reduce meiotic recombination several hundred fold. No alleles of RED1 or HOP1 were isolated, consistent with the proposal that these genes may be primarily involved with chromosome pairing and not exchange.

Bibliography

Malone, R. E., Bullard, S., Hermiston, M., Rieger, R., Cool, M., & Galbraith, A. (1991). Isolation of mutants defective in early steps of meiotic recombination in the yeast Saccharomyces cerevisiae. Genetics, 128(1), 79â88.

Authors 6

R E Malone (first)
S Bullard (additional)
M Hermiston (additional)
R Rieger (additional)
M Cool (additional)
A Galbraith (additional)

References 0 Referenced 76

None

Dates

Type	When
Created	4 years, 7 months ago (Jan. 13, 2021, 12:46 p.m.)
Deposited	4 years, 4 months ago (April 22, 2021, 4:40 p.m.)
Indexed	5 months ago (March 22, 2025, 7:24 a.m.)
Issued	34 years, 3 months ago (May 1, 1991)
Published	34 years, 3 months ago (May 1, 1991)
Published Online	34 years, 3 months ago (May 1, 1991)
Published Print	34 years, 3 months ago (May 1, 1991)

Funders 0

None

BibTeX

@article{Malone_1991, title={Isolation of mutants defective in early steps of meiotic recombination in the yeast Saccharomyces cerevisiae.}, volume={128}, ISSN={1943-2631}, url={http://dx.doi.org/10.1093/genetics/128.1.79}, DOI={10.1093/genetics/128.1.79}, number={1}, journal={Genetics}, publisher={Oxford University Press (OUP)}, author={Malone, R E and Bullard, S and Hermiston, M and Rieger, R and Cool, M and Galbraith, A}, year={1991}, month=may, pages={79–88} }

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