DOI: 10.1093/genetics/116.3.389. Homoeosis in Drosophila: The Lethal Syndrome of the <i>Regulator of bithorax</i> (or <i>trithorax</i>) Locus and Its Interaction With Other Homoeotic Loci

Homoeosis in Drosophila: The Lethal Syndrome of the Regulator of bithorax (or trithorax) Locus and Its Interaction With Other Homoeotic Loci

10.1093/genetics/116.3.389

Crossref journal-article

Oxford University Press (OUP)

Genetics (286)

Abstract

ABSTRACT Regulator of bithorax (Rg-bx)- [or trithorax (trx)-] lethal zygotes show anterior transformations of various cuticular features of the larval thorax and abdomen. The Rg-bx - lethal syndrome depends on the dosage of the bithorax gene complex (BX-C), and lack of Rg-bx+ function is antagonistic to posterior transformations displayed by Polycomb (Pc)- embryos. Significantly, when the BX-C is deleted, the Rg-bx - embryos disclose homoeosis of mesothoracic to prothoracic cuticular structures. This homoeotic transformation is due to a reduction in Antennapedia (Antp)+ gene activity and is consequently dependent on the dosage of the Antennapedia gene complex (ANT-C), suggesting that the Rg-bx + activity is necessary for proper expression of the Antp + gene. However, the functional relationship between the Rg-bx and Sex combs reduced (Scr) loci in embryogenesis is still to be established.

Bibliography

Sato, T., & Denell, R. E. (1987). Homoeosis in Drosophila: The Lethal Syndrome of the Regulator of bithorax (or trithorax) Locus and Its Interaction With Other Homoeotic Loci. Genetics, 116(3), 389â398.

Authors 2

Takashi Sato (first)
Robin E Denell (additional)

References 0 Referenced 8

None

Dates

Type	When
Created	4 years, 7 months ago (Jan. 6, 2021, 6:15 a.m.)
Deposited	4 years, 4 months ago (April 22, 2021, 2:27 p.m.)
Indexed	2 years, 1 month ago (July 19, 2023, 11:53 a.m.)
Issued	38 years, 2 months ago (July 1, 1987)
Published	38 years, 2 months ago (July 1, 1987)
Published Online	38 years, 2 months ago (July 1, 1987)
Published Print	38 years, 2 months ago (July 1, 1987)

Funders 0

None

BibTeX

@article{Sato_1987, title={Homoeosis in Drosophila: The Lethal Syndrome of the Regulator of bithorax (or trithorax) Locus and Its Interaction With Other Homoeotic Loci}, volume={116}, ISSN={1943-2631}, url={http://dx.doi.org/10.1093/genetics/116.3.389}, DOI={10.1093/genetics/116.3.389}, number={3}, journal={Genetics}, publisher={Oxford University Press (OUP)}, author={Sato, Takashi and Denell, Robin E}, year={1987}, month=jul, pages={389–398} }

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