Abstract
ABSTRACT We have used a complementary DNA (cDNA) for mouse αA-crystallin to probe genomic DNA for restriction fragment length polymorphisms which could be used to map the αA-crystallin gene locus (Acry-1) in the mouse genome. Ten of 12 restriction endonucleases produced fragment polymorphism among various inbred strains of mice. A comprehensive strain survey conducted with six endonucleases resulted in the discovery of six allelic forms of Acry-1. Linkage analysis was conducted on DNA from three sets of recombinant inbred strains of mice and demonstrated close linkage of Acry-1 with the major histocompatibility complex (H-2) on chromosome 17. Analysis of congenic and recombinant congenic strains of mice confirmed the linkage of Acry-1 and H-2 and located the αA gene to the region between glyoxylase (Glo-1) and H-2K.
Dates
Type | When |
---|---|
Created | 4 years, 8 months ago (Jan. 5, 2021, 11:57 p.m.) |
Deposited | 4 years, 4 months ago (April 22, 2021, 1:47 p.m.) |
Indexed | 4 months, 4 weeks ago (April 8, 2025, 10:21 p.m.) |
Issued | 40 years, 1 month ago (Aug. 1, 1985) |
Published | 40 years, 1 month ago (Aug. 1, 1985) |
Published Online | 40 years, 1 month ago (Aug. 1, 1985) |
Published Print | 40 years, 1 month ago (Aug. 1, 1985) |
@article{Skow_1985, title={THE LOCUS ENCODING αA-CRYSTALLIN IS CLOSELY LINKED TO H-2K ON MOUSE CHROMOSOME 17}, volume={110}, ISSN={1943-2631}, url={http://dx.doi.org/10.1093/genetics/110.4.723}, DOI={10.1093/genetics/110.4.723}, number={4}, journal={Genetics}, publisher={Oxford University Press (OUP)}, author={Skow, Loren C and Donner, Maria E}, year={1985}, month=aug, pages={723–732} }