DOI: 10.1093/genetics/108.1.165. ANALYSIS OF GENETIC MOSAICS OF THE NEMATODE <i>CAENORHABDITIS ELEGANS</i>

ANALYSIS OF GENETIC MOSAICS OF THE NEMATODE CAENORHABDITIS ELEGANS

10.1093/genetics/108.1.165

Crossref journal-article

Oxford University Press (OUP)

Genetics (286)

Abstract

ABSTRACT A new method for producing genetic mosaics, which involves the spontaneous somatic loss of free chromosome fragments, is demonstrated. Four genes that affect the behavior of C. elegans were studied in mosaic animals. The analysis was greatly aided by the fact that the complete cell lineage of wild-type animals is known. Two of the mutant genes affect certain sensory responses and prevent uptake of fluorescein isothiocyanate (FITC) by certain sensory neurons. Mosaic analysis indicated that one of these mutant genes is cell autonomous with respect to its effect on FITC uptake and the other is cell nonautonomous. In the latter case, the genotype of a non-neuronal supporting cell that surrounds the processes of the neurons that normally take up FITC probably is critical. The other two mutant genes affect animal movement. Mosaic analysis indicated that the expression of one of these genes is specific to certain neurons (motor neurons of the ventral and dorsal nerve cords are prime candidates) and the expression of the other gene is specific to muscle cells.

Bibliography

Herman, R. K. (1984). ANALYSIS OF GENETIC MOSAICS OF THE NEMATODE CAENORHABDITIS ELEGANS. Genetics, 108(1), 165â180.

Authors 1

Robert K Herman (first)

References 0 Referenced 65

None

Dates

Type	When
Created	4 years, 7 months ago (Jan. 14, 2021, 11:31 a.m.)
Deposited	4 years, 4 months ago (April 22, 2021, 4:41 p.m.)
Indexed	3 weeks, 4 days ago (July 30, 2025, 8:41 p.m.)
Issued	40 years, 11 months ago (Sept. 1, 1984)
Published	40 years, 11 months ago (Sept. 1, 1984)
Published Online	40 years, 11 months ago (Sept. 1, 1984)
Published Print	40 years, 11 months ago (Sept. 1, 1984)

Funders 0

None

BibTeX

@article{Herman_1984, title={ANALYSIS OF GENETIC MOSAICS OF THE NEMATODE CAENORHABDITIS ELEGANS}, volume={108}, ISSN={1943-2631}, url={http://dx.doi.org/10.1093/genetics/108.1.165}, DOI={10.1093/genetics/108.1.165}, number={1}, journal={Genetics}, publisher={Oxford University Press (OUP)}, author={Herman, Robert K}, year={1984}, month=sep, pages={165–180} }

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