DOI: 10.1093/emboj/21.6.1350. Activation of the<i>Aspergillus</i>PacC zinc finger transcription factor requires two proteolytic steps

Activation of theAspergillusPacC zinc finger transcription factor requires two proteolytic steps

10.1093/emboj/21.6.1350

Crossref journal-article

Springer Science and Business Media LLC

The EMBO Journal (297)

Bibliography

DÃez, E., Ãlvaro, J., Espeso, E. A., Rainbow, L., SuÃ¡rez, T., Tilburn, J., Arst, H. N., & PeÃ±alva, M. Ã. (2002). Activation of theAspergillusPacC zinc finger transcription factor requires two proteolytic steps. The EMBO Journal, 21(6), 1350â1359.

Authors 8

Eliecer Díez (first)
Josué Álvaro (additional)
Eduardo A. Espeso (additional)
Lynne Rainbow (additional)
Teresa Suárez (additional)
Joan Tilburn (additional)
Herbert N. Arst (additional)
Miguel Á. Peñalva (additional)

References 29 Referenced 116

10.1007/BF00297286 / Mol Gen Genet / Two new genes involved in signalling ambient pH in Aspergillus nidulans by Arst (1994)
10.1073/pnas.96.20.11041 / Proc Natl Acad Sci USA / A proteolytic pathway that controls the cholesterol content of membranes, cells and blood by Brown (1999)
10.1016/S0092-8674(00)80675-3 / Cell / Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans by Brown (2000)
10.1007/BF00333978 / Mol Gen Genet / Regulation of gene expression by pH of the growth medium in Aspergillus nidulans by Caddick (1986)
10.1006/bbrc.1998.8378 / Biochem Biophys Res Commun / Calpain: a protease in search of a function? by Carafoli (1998)
{'key': '10.1093/emboj/21.6.1350-BIB0006|embj7594353-citation-0006', 'first-page': '3.71', 'article-title': 'Aspergillus nidulans', 'volume-title': 'Genetic Maps. Locus Maps of Complex Genomes', 'author': 'Clutterbuck', 'year': '1993'} / Genetic Maps. Locus Maps of Complex Genomes / Aspergillus nidulans by Clutterbuck (1993)
10.1016/S0926-6593(66)80120-0 / Biochim Biophys Acta / The induction and repression of nitrate reductase in the fungus Aspergillus nidulans by Cove (1966)
10.1074/jbc.270.48.28519 / J Biol Chem / Signaling of ambient pH in Aspergillus involves a cysteine protease by Denison (1995)
10.1046/j.1365-2958.1998.01058.x / Mol Microbiol / Putative membrane components of signal transduction pathways for ambient pH regulation in Aspergillus and meiosis in Saccharomyces are homologous by Denison (1998)
10.1128/MCB.20.10.3355-3363.2000 / Mol Cell Biol / On the mechanism by which alkaline pH prevents expression of an acid-expressed gene by Espeso (2000)
10.1074/jbc.271.46.28825 / J Biol Chem / Three binding sites for the Aspergillus nidulans PacC zinc finger transcription factor are necessary and sufficient for regulation by ambient pH of the isopenicillin N synthase gene promoter by Espeso (1996)
10.1006/jmbi.1997.1428 / J Mol Biol / Specific DNA recognition by the Aspergillus nidulans three zinc finger transcription factor PacC by Espeso (1997)
10.1093/emboj/19.4.719 / EMBO J / On how a transcription factor can avoid its proteolytic activation in the absence of signal transduction by Espeso (2000)
10.1007/s004380050929 / Mol Gen Genet / The protease activity of a calpain-like cysteine protease in Saccharomyces cerevisiae is required for alkaline adaptation and sporulation by Futai (1999)
10.1146/annurev.immunol.16.1.225 / Annu Rev Immunol / NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses by Ghosh (1998)
10.1016/S0092-8674(00)00080-5 / Cell / Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing by Hoppe (2000)
10.1093/emboj/17.13.3505 / EMBO J / Transducing Hedgehog: the story so far by Ingham (1998)
10.1093/genetics/145.1.63 / Genetics / Evidence for proteolytic activation of Rim1p, a positive regulator of yeast sporulation and invasive growth by Li (1997)
10.1016/S0092-8674(00)80592-9 / Cell / Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus by Methot (1999)
10.1128/MCB.19.2.1390 / Mol Cell Biol / Specificity determinants of proteolytic processing of Aspergillus PacC transcription factor are remote from the processing site and processing occurs in yeast if pH signalling is bypassed by Mingot (1999)
10.1128/MCB.21.5.1688-1699.2001 / Mol Cell Biol / Ambient pH signaling regulates nuclear localization of the Aspergillus nidulans PacC transcription factor by Mingot (2001)
10.1046/j.1365-2958.2000.02085.x / Mol Microbiol / A defined sequence within the 3′ UTR of the areA transcript is sufficient to mediate nitrogen metabolite signalling via accelerated deadenyl ation by Morozov (2000)
10.1128/jb.179.5.1832-1835.1997 / J Bacteriol / Characterization of the pH signal transduction pathway gene palA of Aspergillus nidulans and identification of possible homologs by Negrete-Urtasun (1997)
10.1046/j.1365-2958.1999.01540.x / Mol Microbiol / Ambient pH signal transduction in Aspergillus: completion of gene characterization by Negrete-Urtasun (1999)
10.1101/gad.9.13.1622 / Genes Dev / Activation of the Aspergillus PacC transcription factor in response to alkaline ambient pH requires proteolysis of the carboxy-terminal moiety by Orejas (1995)
10.1016/S0168-9525(99)01840-5 / Trends Genet / Gli proteins and Hedgehog signaling: development and cancer by Ruiz i Altaba (1999)
10.1016/0378-1119(83)90191-9 / Gene / Transformation by integration in Aspergillus nidulans by Tilburn (1983)
10.1002/j.1460-2075.1995.tb07056.x / EMBO J / The Aspergillus PacC zinc finger transcription factor mediates regulation of both acid- and alkaline-expressed genes by ambient pH by Tilburn (1995)
10.1128/JB.183.23.6917-6923.2001 / J Bacteriol / Yeast PalA/AIP1/Alix homolog Rim20p associates with a PEST-like region and is required for its proteolytic cleavage by Xu (2001)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 6:42 p.m.)
Deposited	1 year, 8 months ago (Dec. 18, 2023, 4 p.m.)
Indexed	4 days, 13 hours ago (Aug. 31, 2025, 6:16 a.m.)
Issued	23 years, 5 months ago (March 15, 2002)
Published	23 years, 5 months ago (March 15, 2002)
Published Online	23 years, 5 months ago (March 15, 2002)
Published Print	23 years, 5 months ago (March 15, 2002)

Funders 0

None

BibTeX

@article{D_ez_2002, title={Activation of theAspergillusPacC zinc finger transcription factor requires two proteolytic steps}, volume={21}, ISSN={0261-4189}, url={http://dx.doi.org/10.1093/emboj/21.6.1350}, DOI={10.1093/emboj/21.6.1350}, number={6}, journal={The EMBO Journal}, publisher={Springer Science and Business Media LLC}, author={Díez, Eliecer and Álvaro, Josué and Espeso, Eduardo A. and Rainbow, Lynne and Suárez, Teresa and Tilburn, Joan and Arst, Herbert N. and Peñalva, Miguel Á.}, year={2002}, month=mar, pages={1350–1359} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        31
      ]
    ],
    "date-time": "2025-08-31T10:16:20Z",
    "timestamp": 1756635380543
  },
  "reference-count": 29,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "6",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2015,
            9,
            1
          ]
        ],
        "date-time": "2015-09-01T00:00:00Z",
        "timestamp": 1441065600000
      },
      "content-version": "tdm",
      "delay-in-days": 4918,
      "URL": "http://doi.wiley.com/10.1002/tdm_license_1.1"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2002,
        3,
        15
      ]
    ]
  },
  "DOI": "10.1093/emboj/21.6.1350",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        26
      ]
    ],
    "date-time": "2002-07-26T22:42:52Z",
    "timestamp": 1027723372000
  },
  "page": "1350-1359",
  "source": "Crossref",
  "is-referenced-by-count": 116,
  "title": "Activation of the<i>Aspergillus</i>PacC zinc finger transcription factor requires two proteolytic steps",
  "prefix": "10.1038",
  "volume": "21",
  "author": [
    {
      "given": "Eliecer",
      "family": "D\u00edez",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Departamento de Microbiolog\u00eda Molecular, Centro de Investigaciones Biol\u00f3gicas del CSIC, Vel\u00e1zquez 144; Madrid 28006 Spain"
        }
      ]
    },
    {
      "given": "Josu\u00e9",
      "family": "\u00c1lvaro",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Departamento de Microbiolog\u00eda Molecular, Centro de Investigaciones Biol\u00f3gicas del CSIC, Vel\u00e1zquez 144; Madrid 28006 Spain"
        }
      ]
    },
    {
      "given": "Eduardo A.",
      "family": "Espeso",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Departamento de Microbiolog\u00eda Molecular, Centro de Investigaciones Biol\u00f3gicas del CSIC, Vel\u00e1zquez 144; Madrid 28006 Spain"
        }
      ]
    },
    {
      "given": "Lynne",
      "family": "Rainbow",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Infectious Diseases, Faculty of Medicine, Imperial College of Science, Technology & Medicine, Hammersmith Hospital; Du Cane Road London W12 0NN UK"
        },
        {
          "name": "Present address: Division of Reproductive and Child Health, Medical and Molecular Genetics, The Medical School, Edgbaston; Birmingham B15 2TT UK"
        }
      ]
    },
    {
      "given": "Teresa",
      "family": "Su\u00e1rez",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Departamento de Microbiolog\u00eda Molecular, Centro de Investigaciones Biol\u00f3gicas del CSIC, Vel\u00e1zquez 144; Madrid 28006 Spain"
        }
      ]
    },
    {
      "given": "Joan",
      "family": "Tilburn",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Infectious Diseases, Faculty of Medicine, Imperial College of Science, Technology & Medicine, Hammersmith Hospital; Du Cane Road London W12 0NN UK"
        }
      ]
    },
    {
      "suffix": "Jr",
      "given": "Herbert N.",
      "family": "Arst",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Infectious Diseases, Faculty of Medicine, Imperial College of Science, Technology & Medicine, Hammersmith Hospital; Du Cane Road London W12 0NN UK"
        }
      ]
    },
    {
      "given": "Miguel \u00c1.",
      "family": "Pe\u00f1alva",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Departamento de Microbiolog\u00eda Molecular, Centro de Investigaciones Biol\u00f3gicas del CSIC, Vel\u00e1zquez 144; Madrid 28006 Spain"
        }
      ]
    }
  ],
  "member": "297",
  "published-online": {
    "date-parts": [
      [
        2002,
        3,
        15
      ]
    ]
  },
  "reference": [
    {
      "key": "10.1093/emboj/21.6.1350-BIB0001|embj7594353-citation-0001",
      "doi-asserted-by": "crossref",
      "first-page": "787",
      "DOI": "10.1007/BF00297286",
      "article-title": "Two new genes involved in signalling ambient pH in Aspergillus nidulans",
      "volume": "245",
      "author": "Arst",
      "year": "1994",
      "journal-title": "Mol Gen Genet"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0002|embj7594353-citation-0002",
      "doi-asserted-by": "crossref",
      "first-page": "11041",
      "DOI": "10.1073/pnas.96.20.11041",
      "article-title": "A proteolytic pathway that controls the cholesterol content of membranes, cells and blood",
      "volume": "96",
      "author": "Brown",
      "year": "1999",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0003|embj7594353-citation-0003",
      "doi-asserted-by": "crossref",
      "first-page": "391",
      "DOI": "10.1016/S0092-8674(00)80675-3",
      "article-title": "Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans",
      "volume": "100",
      "author": "Brown",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0004|embj7594353-citation-0004",
      "doi-asserted-by": "crossref",
      "first-page": "346",
      "DOI": "10.1007/BF00333978",
      "article-title": "Regulation of gene expression by pH of the growth medium in Aspergillus nidulans",
      "volume": "203",
      "author": "Caddick",
      "year": "1986",
      "journal-title": "Mol Gen Genet"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0005|embj7594353-citation-0005",
      "doi-asserted-by": "crossref",
      "first-page": "193",
      "DOI": "10.1006/bbrc.1998.8378",
      "article-title": "Calpain: a protease in search of a function?",
      "volume": "247",
      "author": "Carafoli",
      "year": "1998",
      "journal-title": "Biochem Biophys Res Commun"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0006|embj7594353-citation-0006",
      "first-page": "3.71",
      "article-title": "Aspergillus nidulans",
      "volume-title": "Genetic Maps. Locus Maps of Complex Genomes",
      "author": "Clutterbuck",
      "year": "1993"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0007|embj7594353-citation-0007",
      "doi-asserted-by": "crossref",
      "first-page": "51",
      "DOI": "10.1016/S0926-6593(66)80120-0",
      "article-title": "The induction and repression of nitrate reductase in the fungus Aspergillus nidulans",
      "volume": "113",
      "author": "Cove",
      "year": "1966",
      "journal-title": "Biochim Biophys Acta"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0008|embj7594353-citation-0008",
      "doi-asserted-by": "crossref",
      "first-page": "28519",
      "DOI": "10.1074/jbc.270.48.28519",
      "article-title": "Signaling of ambient pH in Aspergillus involves a cysteine protease",
      "volume": "270",
      "author": "Denison",
      "year": "1995",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0009|embj7594353-citation-0009",
      "doi-asserted-by": "crossref",
      "first-page": "259",
      "DOI": "10.1046/j.1365-2958.1998.01058.x",
      "article-title": "Putative membrane components of signal transduction pathways for ambient pH regulation in Aspergillus and meiosis in Saccharomyces are homologous",
      "volume": "30",
      "author": "Denison",
      "year": "1998",
      "journal-title": "Mol Microbiol"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0010|embj7594353-citation-0010",
      "doi-asserted-by": "crossref",
      "first-page": "3355",
      "DOI": "10.1128/MCB.20.10.3355-3363.2000",
      "article-title": "On the mechanism by which alkaline pH prevents expression of an acid-expressed gene",
      "volume": "20",
      "author": "Espeso",
      "year": "2000",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0011|embj7594353-citation-0011",
      "doi-asserted-by": "crossref",
      "first-page": "28825",
      "DOI": "10.1074/jbc.271.46.28825",
      "article-title": "Three binding sites for the Aspergillus nidulans PacC zinc finger transcription factor are necessary and sufficient for regulation by ambient pH of the isopenicillin N synthase gene promoter",
      "volume": "271",
      "author": "Espeso",
      "year": "1996",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0012|embj7594353-citation-0012",
      "doi-asserted-by": "crossref",
      "first-page": "466",
      "DOI": "10.1006/jmbi.1997.1428",
      "article-title": "Specific DNA recognition by the Aspergillus nidulans three zinc finger transcription factor PacC",
      "volume": "274",
      "author": "Espeso",
      "year": "1997",
      "journal-title": "J Mol Biol"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0013|embj7594353-citation-0013",
      "doi-asserted-by": "crossref",
      "first-page": "719",
      "DOI": "10.1093/emboj/19.4.719",
      "article-title": "On how a transcription factor can avoid its proteolytic activation in the absence of signal transduction",
      "volume": "19",
      "author": "Espeso",
      "year": "2000",
      "journal-title": "EMBO J"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0014|embj7594353-citation-0014",
      "doi-asserted-by": "crossref",
      "first-page": "559",
      "DOI": "10.1007/s004380050929",
      "article-title": "The protease activity of a calpain-like cysteine protease in Saccharomyces cerevisiae is required for alkaline adaptation and sporulation",
      "volume": "260",
      "author": "Futai",
      "year": "1999",
      "journal-title": "Mol Gen Genet"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0015|embj7594353-citation-0015",
      "doi-asserted-by": "crossref",
      "first-page": "225",
      "DOI": "10.1146/annurev.immunol.16.1.225",
      "article-title": "NF-\u03baB and Rel proteins: evolutionarily conserved mediators of immune responses",
      "volume": "16",
      "author": "Ghosh",
      "year": "1998",
      "journal-title": "Annu Rev Immunol"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0016|embj7594353-citation-0016",
      "doi-asserted-by": "crossref",
      "first-page": "577",
      "DOI": "10.1016/S0092-8674(00)00080-5",
      "article-title": "Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing",
      "volume": "102",
      "author": "Hoppe",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0017|embj7594353-citation-0017",
      "doi-asserted-by": "crossref",
      "first-page": "3505",
      "DOI": "10.1093/emboj/17.13.3505",
      "article-title": "Transducing Hedgehog: the story so far",
      "volume": "17",
      "author": "Ingham",
      "year": "1998",
      "journal-title": "EMBO J"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0018|embj7594353-citation-0018",
      "doi-asserted-by": "crossref",
      "first-page": "63",
      "DOI": "10.1093/genetics/145.1.63",
      "article-title": "Evidence for proteolytic activation of Rim1p, a positive regulator of yeast sporulation and invasive growth",
      "volume": "145",
      "author": "Li",
      "year": "1997",
      "journal-title": "Genetics"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0019|embj7594353-citation-0019",
      "doi-asserted-by": "crossref",
      "first-page": "819",
      "DOI": "10.1016/S0092-8674(00)80592-9",
      "article-title": "Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus",
      "volume": "96",
      "author": "Methot",
      "year": "1999",
      "journal-title": "Cell"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0020|embj7594353-citation-0020",
      "doi-asserted-by": "crossref",
      "first-page": "1390",
      "DOI": "10.1128/MCB.19.2.1390",
      "article-title": "Specificity determinants of proteolytic processing of Aspergillus PacC transcription factor are remote from the processing site and processing occurs in yeast if pH signalling is bypassed",
      "volume": "19",
      "author": "Mingot",
      "year": "1999",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0021|embj7594353-citation-0021",
      "doi-asserted-by": "crossref",
      "first-page": "1688",
      "DOI": "10.1128/MCB.21.5.1688-1699.2001",
      "article-title": "Ambient pH signaling regulates nuclear localization of the Aspergillus nidulans PacC transcription factor",
      "volume": "21",
      "author": "Mingot",
      "year": "2001",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0022|embj7594353-citation-0022",
      "doi-asserted-by": "crossref",
      "first-page": "1248",
      "DOI": "10.1046/j.1365-2958.2000.02085.x",
      "article-title": "A defined sequence within the 3\u2032 UTR of the areA transcript is sufficient to mediate nitrogen metabolite signalling via accelerated deadenyl ation",
      "volume": "37",
      "author": "Morozov",
      "year": "2000",
      "journal-title": "Mol Microbiol"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0023|embj7594353-citation-0023",
      "doi-asserted-by": "crossref",
      "first-page": "1832",
      "DOI": "10.1128/jb.179.5.1832-1835.1997",
      "article-title": "Characterization of the pH signal transduction pathway gene palA of Aspergillus nidulans and identification of possible homologs",
      "volume": "179",
      "author": "Negrete-Urtasun",
      "year": "1997",
      "journal-title": "J Bacteriol"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0024|embj7594353-citation-0024",
      "doi-asserted-by": "crossref",
      "first-page": "994",
      "DOI": "10.1046/j.1365-2958.1999.01540.x",
      "article-title": "Ambient pH signal transduction in Aspergillus: completion of gene characterization",
      "volume": "33",
      "author": "Negrete-Urtasun",
      "year": "1999",
      "journal-title": "Mol Microbiol"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0025|embj7594353-citation-0025",
      "doi-asserted-by": "crossref",
      "first-page": "1622",
      "DOI": "10.1101/gad.9.13.1622",
      "article-title": "Activation of the Aspergillus PacC transcription factor in response to alkaline ambient pH requires proteolysis of the carboxy-terminal moiety",
      "volume": "9",
      "author": "Orejas",
      "year": "1995",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0026|embj7594353-citation-0026",
      "doi-asserted-by": "crossref",
      "first-page": "418",
      "DOI": "10.1016/S0168-9525(99)01840-5",
      "article-title": "Gli proteins and Hedgehog signaling: development and cancer",
      "volume": "15",
      "author": "Ruiz i Altaba",
      "year": "1999",
      "journal-title": "Trends Genet"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0027|embj7594353-citation-0027",
      "doi-asserted-by": "crossref",
      "first-page": "205",
      "DOI": "10.1016/0378-1119(83)90191-9",
      "article-title": "Transformation by integration in Aspergillus nidulans",
      "volume": "26",
      "author": "Tilburn",
      "year": "1983",
      "journal-title": "Gene"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0028|embj7594353-citation-0028",
      "doi-asserted-by": "crossref",
      "first-page": "779",
      "DOI": "10.1002/j.1460-2075.1995.tb07056.x",
      "article-title": "The Aspergillus PacC zinc finger transcription factor mediates regulation of both acid- and alkaline-expressed genes by ambient pH",
      "volume": "14",
      "author": "Tilburn",
      "year": "1995",
      "journal-title": "EMBO J"
    },
    {
      "key": "10.1093/emboj/21.6.1350-BIB0029|embj7594353-citation-0029",
      "doi-asserted-by": "crossref",
      "first-page": "6917",
      "DOI": "10.1128/JB.183.23.6917-6923.2001",
      "article-title": "Yeast PalA/AIP1/Alix homolog Rim20p associates with a PEST-like region and is required for its proteolytic cleavage",
      "volume": "183",
      "author": "Xu",
      "year": "2001",
      "journal-title": "J Bacteriol"
    }
  ],
  "container-title": "The EMBO Journal",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1093%2Femboj%2F21.6.1350",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://onlinelibrary.wiley.com/doi/full/10.1093/emboj/21.6.1350",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        12,
        18
      ]
    ],
    "date-time": "2023-12-18T21:00:47Z",
    "timestamp": 1702933247000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "http://emboj.embopress.org/cgi/doi/10.1093/emboj/21.6.1350"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2002,
        3,
        15
      ]
    ]
  },
  "references-count": 29,
  "journal-issue": {
    "issue": "6",
    "published-print": {
      "date-parts": [
        [
          2002,
          3,
          15
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1093/emboj/21.6.1350",
  "relation": {},
  "ISSN": [
    "0261-4189"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        2002,
        3,
        15
      ]
    ]
  }
}