DOI: 10.1093/emboj/19.19.5167. Crystal structure of FadR, a fatty acid-responsive transcription factor with a novel acyl coenzyme A-binding fold

Crystal structure of FadR, a fatty acid-responsive transcription factor with a novel acyl coenzyme A-binding fold

10.1093/emboj/19.19.5167

Crossref journal-article

Springer Science and Business Media LLC

The EMBO Journal (297)

Bibliography

van Aalten, D. M. F., DiRusso, C. C., Knudsen, J., & Wierenga, R. K. (2000). Crystal structure of FadR, a fatty acid-responsive transcription factor with a novel acyl coenzyme A-binding fold. The EMBO Journal, 19(19), 5167â5177.

Authors 4

D.M.F van Aalten (first)
C.C. DiRusso (additional)
J. Knudsen (additional)
R.K. Wierenga (additional)

References 53 Referenced 123

10.1093/nar/28.1.263 / Nucleic Acids Res by Bateman A (2000)
10.1093/jn/130.2.305S / J Nutr by Black PN (2000)
10.1107/S0108767398011465 / Acta Crystallogr by Brunger AT (1998)
10.1107/S0907444994003112 / Acta Crystallogr D (1994)
Cowtan K (1994) <i>CCP4 ESF-EACBM Newslett Protein Crystallogr</i>, <b>31</b>, 34–38.
10.1016/S0076-6879(97)76073-7 / Methods Enzymol by de la Fortelle E (1997)
10.1093/nar/16.16.7995 / Nucleic Acids Res by DiRusso CC (1988)
10.1016/S0021-9258(18)42497-0 / J Biol Chem by DiRusso CC (1992)
10.1111/j.1365-2958.1993.tb01122.x / Mol Microbiol by DiRusso CC (1993)
10.1074/jbc.273.50.33652 / J Biol Chem by DiRusso CC (1998)
10.1016/S0163-7827(98)00022-8 / Prog Lipid Res by DiRusso CC (1999)
10.1128/jb.178.22.6443-6450.1996 / J Bacteriol by Farewell A (1996)
10.1128/jb.178.15.4704-4709.1996 / J Bacteriol by Gui L (1996)
10.1093/emboj/18.6.1435 / EMBO J by Hall DR (1999)
10.1111/j.1574-6968.1991.tb04544.x / FEMS Microbiol Lett by Haydon DJ (1991)
10.1038/33185 / Nature by Hertz R (1998)
10.1093/nar/27.1.215 / Nucleic Acids Res by Hoffman K (1999)
10.1006/jmbi.1993.1489 / J Mol Biol by Holm L (1993)
10.1016/S0021-9258(18)83280-X / J Biol Chem by Jackowski S (1989)
10.1107/S0108767390010224 / Acta Crystallogr A by Jones TA (1991)
10.1002/bip.360221211 / Biopolymers by Kabsch W (1983)
10.1107/S0907444993011333 / Acta Crystallogr D by Kleywegt GJ (1994)
10.1107/S0021889892009944 / J Appl Crystallogr by Laskowski RA (1993)
10.1016/S0969-2126(97)00186-X / Structure by Lerche MH (1997)
10.1126/science.271.5253.1247 / Science by Lewis M (1996)
10.1073/pnas.92.3.669 / Proc Natl Acad Sci USA by Mahan MJ (1995)
10.1016/S0021-9258(18)37698-1 / J Biol Chem by Miwa Y (1988)
{'key': '7593331-b28', 'first-page': '536', 'volume': '247', 'author': 'Murzin AG', 'year': '1995', 'journal-title': 'J Mol Biol'} / J Mol Biol by Murzin AG (1995)
10.1107/S0108767393007597 / Acta Crystallogr A by Navaza J (1994)
10.1016/S0969-2126(97)00260-8 / Structure by Orengo CA (1997)
10.1016/S0076-6879(97)76066-X / Methods Enzymol by Otwinowski Z (1997)
10.1111/j.1432-1033.1969.tb19644.x / Eur J Biochem by Overath P (1969)
10.1126/science.277.5332.1676 / Science by Pebay-Peyroula E (1997)
10.1128/jb.178.7.2051-2059.1996 / J Bacteriol by Pellicer MT (1996)
10.1038/8263 / Nature Struct Biol by Perrakis A (1999)
10.1074/jbc.270.3.1092 / J Biol Chem by Raman N (1995)
10.1074/jbc.272.49.30645 / J Biol Chem by Raman N (1997)
10.1007/BF00279746 / Mol Gen Genet by Rossbach S (1994)
{'key': '7593331-b40', 'first-page': '53', 'volume': '10', 'author': 'Rost B', 'year': '1994', 'journal-title': 'Comput Appl Biosci'} / Comput Appl Biosci by Rost B (1994)
10.1073/pnas.86.20.7736 / Proc Natl Acad Sci USA by Sacchettini JC (1989)
10.1128/jb.178.15.4576-4581.1996 / J Bacteriol by Schoeck F (1996)
10.1126/science.1653449 / Science by Schultz SC (1991)
10.1126/science.284.5421.1841 / Science by Schwartz T (1999)
10.1099/13500872-145-1-15 / Microbiology by Spector MP (1999)
10.1107/S0907444999000839 / Acta Crystallogr D by Terwilliger TC (1999)
10.1093/nar/22.22.4673 / Nucleic Acids Res by Thompson JD (1994)
10.1016/S0076-6879(97)76080-4 / Methods Enzymol by Tong L (1997)
10.1107/S0907444900000937 / Acta Crystallogr D by van Aalten DMF (2000)
10.1016/0263-7855(90)80070-V / J Mol Graph by Vriend G (1990)
10.1006/jmbi.1993.1239 / J Mol Biol by Winter NS (1993)
10.1006/jmbi.1993.1270 / J Mol Biol by Yoshida K-I (1993)
10.1128/jb.177.16.4813-4816.1995 / J Bacteriol by Yoshida K-I (1995)
10.1101/gad.13.6.666 / Genes Dev by Zheng N (1999)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 6:50 p.m.)
Deposited	1 year, 8 months ago (Dec. 18, 2023, 4:01 p.m.)
Indexed	1 month, 2 weeks ago (July 12, 2025, 6:53 p.m.)
Issued	24 years, 10 months ago (Oct. 2, 2000)
Published	24 years, 10 months ago (Oct. 2, 2000)
Published Print	24 years, 10 months ago (Oct. 2, 2000)

Funders 0

None

BibTeX

@article{van_Aalten_2000, title={Crystal structure of FadR, a fatty acid-responsive transcription factor with a novel acyl coenzyme A-binding fold}, volume={19}, ISSN={1460-2075}, url={http://dx.doi.org/10.1093/emboj/19.19.5167}, DOI={10.1093/emboj/19.19.5167}, number={19}, journal={The EMBO Journal}, publisher={Springer Science and Business Media LLC}, author={van Aalten, D.M.F and DiRusso, C.C. and Knudsen, J. and Wierenga, R.K.}, year={2000}, month=oct, pages={5167–5177} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        12
      ]
    ],
    "date-time": "2025-07-12T22:53:11Z",
    "timestamp": 1752360791893
  },
  "reference-count": 53,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "19",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2015,
            9,
            1
          ]
        ],
        "date-time": "2015-09-01T00:00:00Z",
        "timestamp": 1441065600000
      },
      "content-version": "tdm",
      "delay-in-days": 5447,
      "URL": "http://doi.wiley.com/10.1002/tdm_license_1.1"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2000,
        10,
        2
      ]
    ]
  },
  "DOI": "10.1093/emboj/19.19.5167",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        26
      ]
    ],
    "date-time": "2002-07-26T22:50:23Z",
    "timestamp": 1027723823000
  },
  "page": "5167-5177",
  "source": "Crossref",
  "is-referenced-by-count": 123,
  "title": "Crystal structure of FadR, a fatty acid-responsive transcription factor with a novel acyl coenzyme A-binding fold",
  "prefix": "10.1038",
  "volume": "19",
  "author": [
    {
      "given": "D.M.F",
      "family": "van Aalten",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "C.C.",
      "family": "DiRusso",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "J.",
      "family": "Knudsen",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "R.K.",
      "family": "Wierenga",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "297",
  "reference": [
    {
      "key": "7593331-b1",
      "doi-asserted-by": "crossref",
      "first-page": "263",
      "DOI": "10.1093/nar/28.1.263",
      "volume": "28",
      "author": "Bateman A",
      "year": "2000",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "7593331-b2",
      "doi-asserted-by": "crossref",
      "first-page": "305S",
      "DOI": "10.1093/jn/130.2.305S",
      "volume": "130",
      "author": "Black PN",
      "year": "2000",
      "journal-title": "J Nutr"
    },
    {
      "key": "7593331-b3",
      "doi-asserted-by": "crossref",
      "first-page": "905",
      "DOI": "10.1107/S0108767398011465",
      "volume": "54",
      "author": "Brunger AT",
      "year": "1998",
      "journal-title": "Acta Crystallogr"
    },
    {
      "key": "7593331-b4",
      "doi-asserted-by": "crossref",
      "first-page": "760",
      "DOI": "10.1107/S0907444994003112",
      "volume": "50",
      "year": "1994",
      "journal-title": "Acta Crystallogr D"
    },
    {
      "key": "7593331-b5",
      "unstructured": "Cowtan K (1994) <i>CCP4 ESF-EACBM Newslett Protein Crystallogr</i>, <b>31</b>, 34&ndash;38."
    },
    {
      "key": "7593331-b6",
      "doi-asserted-by": "crossref",
      "first-page": "472",
      "DOI": "10.1016/S0076-6879(97)76073-7",
      "volume": "276",
      "author": "de la Fortelle E",
      "year": "1997",
      "journal-title": "Methods Enzymol"
    },
    {
      "key": "7593331-b7",
      "doi-asserted-by": "crossref",
      "first-page": "7995",
      "DOI": "10.1093/nar/16.16.7995",
      "volume": "16",
      "author": "DiRusso CC",
      "year": "1988",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "7593331-b9",
      "doi-asserted-by": "crossref",
      "first-page": "8685",
      "DOI": "10.1016/S0021-9258(18)42497-0",
      "volume": "267",
      "author": "DiRusso CC",
      "year": "1992",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "7593331-b10",
      "doi-asserted-by": "crossref",
      "first-page": "311",
      "DOI": "10.1111/j.1365-2958.1993.tb01122.x",
      "volume": "7",
      "author": "DiRusso CC",
      "year": "1993",
      "journal-title": "Mol Microbiol"
    },
    {
      "key": "7593331-b11",
      "doi-asserted-by": "crossref",
      "first-page": "33652",
      "DOI": "10.1074/jbc.273.50.33652",
      "volume": "273",
      "author": "DiRusso CC",
      "year": "1998",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "7593331-b8",
      "doi-asserted-by": "crossref",
      "first-page": "129",
      "DOI": "10.1016/S0163-7827(98)00022-8",
      "volume": "38",
      "author": "DiRusso CC",
      "year": "1999",
      "journal-title": "Prog Lipid Res"
    },
    {
      "key": "7593331-b12",
      "doi-asserted-by": "crossref",
      "first-page": "6443",
      "DOI": "10.1128/jb.178.22.6443-6450.1996",
      "volume": "178",
      "author": "Farewell A",
      "year": "1996",
      "journal-title": "J Bacteriol"
    },
    {
      "key": "7593331-b13",
      "doi-asserted-by": "crossref",
      "first-page": "4704",
      "DOI": "10.1128/jb.178.15.4704-4709.1996",
      "volume": "178",
      "author": "Gui L",
      "year": "1996",
      "journal-title": "J Bacteriol"
    },
    {
      "key": "7593331-b14",
      "doi-asserted-by": "crossref",
      "first-page": "1435",
      "DOI": "10.1093/emboj/18.6.1435",
      "volume": "18",
      "author": "Hall DR",
      "year": "1999",
      "journal-title": "EMBO J"
    },
    {
      "key": "7593331-b15",
      "doi-asserted-by": "crossref",
      "first-page": "291",
      "DOI": "10.1111/j.1574-6968.1991.tb04544.x",
      "volume": "79",
      "author": "Haydon DJ",
      "year": "1991",
      "journal-title": "FEMS Microbiol Lett"
    },
    {
      "key": "7593331-b16",
      "doi-asserted-by": "crossref",
      "first-page": "512",
      "DOI": "10.1038/33185",
      "volume": "392",
      "author": "Hertz R",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "7593331-b17",
      "doi-asserted-by": "crossref",
      "first-page": "215",
      "DOI": "10.1093/nar/27.1.215",
      "volume": "27",
      "author": "Hoffman K",
      "year": "1999",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "7593331-b18",
      "doi-asserted-by": "crossref",
      "first-page": "123",
      "DOI": "10.1006/jmbi.1993.1489",
      "volume": "233",
      "author": "Holm L",
      "year": "1993",
      "journal-title": "J Mol Biol"
    },
    {
      "key": "7593331-b19",
      "doi-asserted-by": "crossref",
      "first-page": "7264",
      "DOI": "10.1016/S0021-9258(18)83280-X",
      "volume": "264",
      "author": "Jackowski S",
      "year": "1989",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "7593331-b20",
      "doi-asserted-by": "crossref",
      "first-page": "110",
      "DOI": "10.1107/S0108767390010224",
      "volume": "47",
      "author": "Jones TA",
      "year": "1991",
      "journal-title": "Acta Crystallogr A"
    },
    {
      "key": "7593331-b21",
      "doi-asserted-by": "crossref",
      "first-page": "2577",
      "DOI": "10.1002/bip.360221211",
      "volume": "22",
      "author": "Kabsch W",
      "year": "1983",
      "journal-title": "Biopolymers"
    },
    {
      "key": "7593331-b22",
      "doi-asserted-by": "crossref",
      "first-page": "178",
      "DOI": "10.1107/S0907444993011333",
      "volume": "50",
      "author": "Kleywegt GJ",
      "year": "1994",
      "journal-title": "Acta Crystallogr D"
    },
    {
      "key": "7593331-b23",
      "doi-asserted-by": "crossref",
      "first-page": "283",
      "DOI": "10.1107/S0021889892009944",
      "volume": "26",
      "author": "Laskowski RA",
      "year": "1993",
      "journal-title": "J Appl Crystallogr"
    },
    {
      "key": "7593331-b24",
      "doi-asserted-by": "crossref",
      "first-page": "291",
      "DOI": "10.1016/S0969-2126(97)00186-X",
      "volume": "5",
      "author": "Lerche MH",
      "year": "1997",
      "journal-title": "Structure"
    },
    {
      "key": "7593331-b25",
      "doi-asserted-by": "crossref",
      "first-page": "1247",
      "DOI": "10.1126/science.271.5253.1247",
      "volume": "271",
      "author": "Lewis M",
      "year": "1996",
      "journal-title": "Science"
    },
    {
      "key": "7593331-b26",
      "doi-asserted-by": "crossref",
      "first-page": "669",
      "DOI": "10.1073/pnas.92.3.669",
      "volume": "92",
      "author": "Mahan MJ",
      "year": "1995",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "7593331-b27",
      "doi-asserted-by": "crossref",
      "first-page": "13252",
      "DOI": "10.1016/S0021-9258(18)37698-1",
      "volume": "263",
      "author": "Miwa Y",
      "year": "1988",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "7593331-b28",
      "first-page": "536",
      "volume": "247",
      "author": "Murzin AG",
      "year": "1995",
      "journal-title": "J Mol Biol"
    },
    {
      "key": "7593331-b29",
      "doi-asserted-by": "crossref",
      "first-page": "157",
      "DOI": "10.1107/S0108767393007597",
      "volume": "50",
      "author": "Navaza J",
      "year": "1994",
      "journal-title": "Acta Crystallogr A"
    },
    {
      "key": "7593331-b30",
      "doi-asserted-by": "crossref",
      "first-page": "1093",
      "DOI": "10.1016/S0969-2126(97)00260-8",
      "volume": "5",
      "author": "Orengo CA",
      "year": "1997",
      "journal-title": "Structure"
    },
    {
      "key": "7593331-b32",
      "doi-asserted-by": "crossref",
      "first-page": "307",
      "DOI": "10.1016/S0076-6879(97)76066-X",
      "volume": "276",
      "author": "Otwinowski Z",
      "year": "1997",
      "journal-title": "Methods Enzymol"
    },
    {
      "key": "7593331-b33",
      "doi-asserted-by": "crossref",
      "first-page": "559",
      "DOI": "10.1111/j.1432-1033.1969.tb19644.x",
      "volume": "7",
      "author": "Overath P",
      "year": "1969",
      "journal-title": "Eur J Biochem"
    },
    {
      "key": "7593331-b34",
      "doi-asserted-by": "crossref",
      "first-page": "1676",
      "DOI": "10.1126/science.277.5332.1676",
      "volume": "277",
      "author": "Pebay-Peyroula E",
      "year": "1997",
      "journal-title": "Science"
    },
    {
      "key": "7593331-b35",
      "doi-asserted-by": "crossref",
      "first-page": "2051",
      "DOI": "10.1128/jb.178.7.2051-2059.1996",
      "volume": "178",
      "author": "Pellicer MT",
      "year": "1996",
      "journal-title": "J Bacteriol"
    },
    {
      "key": "7593331-b36",
      "doi-asserted-by": "crossref",
      "first-page": "458",
      "DOI": "10.1038/8263",
      "volume": "6",
      "author": "Perrakis A",
      "year": "1999",
      "journal-title": "Nature Struct Biol"
    },
    {
      "key": "7593331-b38",
      "doi-asserted-by": "crossref",
      "first-page": "1092",
      "DOI": "10.1074/jbc.270.3.1092",
      "volume": "270",
      "author": "Raman N",
      "year": "1995",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "7593331-b37",
      "doi-asserted-by": "crossref",
      "first-page": "30645",
      "DOI": "10.1074/jbc.272.49.30645",
      "volume": "272",
      "author": "Raman N",
      "year": "1997",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "7593331-b39",
      "doi-asserted-by": "crossref",
      "first-page": "11",
      "DOI": "10.1007/BF00279746",
      "volume": "245",
      "author": "Rossbach S",
      "year": "1994",
      "journal-title": "Mol Gen Genet"
    },
    {
      "key": "7593331-b40",
      "first-page": "53",
      "volume": "10",
      "author": "Rost B",
      "year": "1994",
      "journal-title": "Comput Appl Biosci"
    },
    {
      "key": "7593331-b41",
      "doi-asserted-by": "crossref",
      "first-page": "7736",
      "DOI": "10.1073/pnas.86.20.7736",
      "volume": "86",
      "author": "Sacchettini JC",
      "year": "1989",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "7593331-b42",
      "doi-asserted-by": "crossref",
      "first-page": "4576",
      "DOI": "10.1128/jb.178.15.4576-4581.1996",
      "volume": "178",
      "author": "Schoeck F",
      "year": "1996",
      "journal-title": "J Bacteriol"
    },
    {
      "key": "7593331-b43",
      "doi-asserted-by": "crossref",
      "first-page": "1001",
      "DOI": "10.1126/science.1653449",
      "volume": "253",
      "author": "Schultz SC",
      "year": "1991",
      "journal-title": "Science"
    },
    {
      "key": "7593331-b44",
      "doi-asserted-by": "crossref",
      "first-page": "1841",
      "DOI": "10.1126/science.284.5421.1841",
      "volume": "284",
      "author": "Schwartz T",
      "year": "1999",
      "journal-title": "Science"
    },
    {
      "key": "7593331-b45",
      "doi-asserted-by": "crossref",
      "first-page": "15",
      "DOI": "10.1099/13500872-145-1-15",
      "volume": "145",
      "author": "Spector MP",
      "year": "1999",
      "journal-title": "Microbiology"
    },
    {
      "key": "7593331-b46",
      "doi-asserted-by": "crossref",
      "first-page": "849",
      "DOI": "10.1107/S0907444999000839",
      "volume": "55",
      "author": "Terwilliger TC",
      "year": "1999",
      "journal-title": "Acta Crystallogr D"
    },
    {
      "key": "7593331-b47",
      "doi-asserted-by": "crossref",
      "first-page": "4673",
      "DOI": "10.1093/nar/22.22.4673",
      "volume": "22",
      "author": "Thompson JD",
      "year": "1994",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "7593331-b48",
      "doi-asserted-by": "crossref",
      "first-page": "594",
      "DOI": "10.1016/S0076-6879(97)76080-4",
      "volume": "276",
      "author": "Tong L",
      "year": "1997",
      "journal-title": "Methods Enzymol"
    },
    {
      "key": "7593331-b49",
      "doi-asserted-by": "crossref",
      "first-page": "469",
      "DOI": "10.1107/S0907444900000937",
      "volume": "56",
      "author": "van Aalten DMF",
      "year": "2000",
      "journal-title": "Acta Crystallogr D"
    },
    {
      "key": "7593331-b51",
      "doi-asserted-by": "crossref",
      "first-page": "52",
      "DOI": "10.1016/0263-7855(90)80070-V",
      "volume": "8",
      "author": "Vriend G",
      "year": "1990",
      "journal-title": "J Mol Graph"
    },
    {
      "key": "7593331-b52",
      "doi-asserted-by": "crossref",
      "first-page": "1247",
      "DOI": "10.1006/jmbi.1993.1239",
      "volume": "230",
      "author": "Winter NS",
      "year": "1993",
      "journal-title": "J Mol Biol"
    },
    {
      "key": "7593331-b53",
      "doi-asserted-by": "crossref",
      "first-page": "167",
      "DOI": "10.1006/jmbi.1993.1270",
      "volume": "231",
      "author": "Yoshida K-I",
      "year": "1993",
      "journal-title": "J Mol Biol"
    },
    {
      "key": "7593331-b54",
      "doi-asserted-by": "crossref",
      "first-page": "4813",
      "DOI": "10.1128/jb.177.16.4813-4816.1995",
      "volume": "177",
      "author": "Yoshida K-I",
      "year": "1995",
      "journal-title": "J Bacteriol"
    },
    {
      "key": "7593331-b55",
      "doi-asserted-by": "crossref",
      "first-page": "666",
      "DOI": "10.1101/gad.13.6.666",
      "volume": "13",
      "author": "Zheng N",
      "year": "1999",
      "journal-title": "Genes Dev"
    }
  ],
  "container-title": "The EMBO Journal",
  "original-title": [],
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1093%2Femboj%2F19.19.5167",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://onlinelibrary.wiley.com/doi/full/10.1093/emboj/19.19.5167",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        12,
        18
      ]
    ],
    "date-time": "2023-12-18T21:01:19Z",
    "timestamp": 1702933279000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "http://emboj.embopress.org/cgi/doi/10.1093/emboj/19.19.5167"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2000,
        10,
        2
      ]
    ]
  },
  "references-count": 53,
  "journal-issue": {
    "issue": "19",
    "published-print": {
      "date-parts": [
        [
          2000,
          10,
          2
        ]
      ]
    }
  },
  "alternative-id": [
    "7593331"
  ],
  "URL": "http://dx.doi.org/10.1093/emboj/19.19.5167",
  "relation": {},
  "ISSN": [
    "0261-4189",
    "1460-2075"
  ],
  "subject": [],
  "container-title-short": "EMBO J",
  "published": {
    "date-parts": [
      [
        2000,
        10,
        2
      ]
    ]
  }
}