DOI: 10.1093/embo-reports/kvf139. CARD games in apoptosis and immunity

10.1093/embo-reports/kvf139

Crossref journal-article

Springer Science and Business Media LLC

EMBO reports (297)

Abstract

A bewildering array of proteins containing the caspase recruitment domain (CARD) have now been identified. Previously, CARD–CARD interactions have been shown to be involved in the assembly of protein complexes that promote caspase processing and activation in the context of apoptosis. However, as the family of CARD‐containing proteins has grown, it has become apparent that the majority of these proteins do not recruit caspases or promote caspase activation. Instead, many participate in NF‐κB signalling pathways associated with innate or adaptive immune responses. Here, we suggest a simplified classification of the CARD proteins based upon their domain structures and discuss the divergent roles of these proteins in the context of host defence.

Bibliography

BouchierâHayes, L., & Martin, S. J. (2002). CARD games in apoptosis and immunity. EMBO Reports, 3(7), 616â621. Portico.

Authors 2

Lisa Bouchier‐Hayes (first)
Seamus J Martin (additional)

References 44 Referenced 131

Dates

Type	When
Created	23 years ago (July 28, 2002, 6:39 p.m.)
Deposited	1 year, 8 months ago (Dec. 18, 2023, 3:55 p.m.)
Indexed	3 months, 1 week ago (May 14, 2025, 9:28 a.m.)
Issued	23 years, 1 month ago (July 1, 2002)
Published	23 years, 1 month ago (July 1, 2002)
Published Online	23 years, 1 month ago (July 1, 2002)
Published Print	23 years, 1 month ago (July 1, 2002)

Funders 0

None

BibTeX

@article{Bouchier_Hayes_2002, title={CARD games in apoptosis and immunity}, volume={3}, ISSN={1469-3178}, url={http://dx.doi.org/10.1093/embo-reports/kvf139}, DOI={10.1093/embo-reports/kvf139}, number={7}, journal={EMBO reports}, publisher={Springer Science and Business Media LLC}, author={Bouchier‐Hayes, Lisa and Martin, Seamus J}, year={2002}, month=jul, pages={616–621} }

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