Abstract
Members of the ATP‐dependent family of chromatin remodeling enzymes play key roles in the regulation of transcription, development, DNA repair and cell cycle. Each of these enzymes are multi‐subunit assemblies that hydrolyze thousands of molecules of ATP in order to change nucleosome positions, disrupt DNA–histone interactions and perhaps destabilize chromatin folding. Here I review recent studies that suggest these potent machines can be ‘tamed’ by one of several mechanisms: targeting their activity to localized regions, blocking their chromatin binding activity or inhibiting their remodeling activity.
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Dates
Type | When |
---|---|
Created | 23 years, 1 month ago (July 26, 2002, 6:55 p.m.) |
Deposited | 1 year, 8 months ago (Dec. 18, 2023, 3:56 p.m.) |
Indexed | 1 month, 3 weeks ago (July 2, 2025, 3:07 p.m.) |
Issued | 23 years, 4 months ago (April 1, 2002) |
Published | 23 years, 4 months ago (April 1, 2002) |
Published Online | 23 years, 4 months ago (April 1, 2002) |
Published Print | 23 years, 4 months ago (April 1, 2002) |
@article{Peterson_2002, title={Chromatin remodeling enzymes: taming the machines}, volume={3}, ISSN={1469-3178}, url={http://dx.doi.org/10.1093/embo-reports/kvf075}, DOI={10.1093/embo-reports/kvf075}, number={4}, journal={EMBO reports}, publisher={Springer Science and Business Media LLC}, author={Peterson, Craig L}, year={2002}, month=apr, pages={319–322} }