DOI: 10.1093/embo-reports/kve046. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

10.1093/embo-reports/kve046

Crossref journal-article

Springer Science and Business Media LLC

EMBO reports (297)

Abstract

Apoptosis signal‐regulating kinase (ASK) 1 is activated in response to various cytotoxic stresses including TNF, Fas and reactive oxygen species (ROS) such as H2O2, and activates c‐Jun NH2‐terminal kinase (JNK) and p38. However, the roles of JNK and p38 signaling pathways during apoptosis have been controversial. Here we show that by deleting ASK1 in mice, TNF‐ and H2O2‐induced sustained activations of JNK and p38 are lost in ASK1−/− embryonic fibroblasts, and that ASK1−/− cells are resistant to TNF‐ and H2O2‐induced apoptosis. TNF‐ but not Fas‐induced apoptosis requires ROS‐dependent activation of ASK1–JNK/p38 pathways. Thus, ASK1 is selectively required for TNF‐ and oxidative stress‐induced sustained activations of JNK/p38 and apoptosis.

Bibliography

Tobiume, K., Matsuzawa, A., Takahashi, T., Nishitoh, H., Morita, K., Takeda, K., Minowa, O., Miyazono, K., Noda, T., & Ichijo, H. (2001). ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Reports, 2(3), 222â228. Portico.

Authors 10

Kei Tobiume (first)
Atsushi Matsuzawa (additional)
Takumi Takahashi (additional)
Hideki Nishitoh (additional)
Kei‐ichi Morita (additional)
Kohsuke Takeda (additional)
Osamu Minowa (additional)
Kohei Miyazono (additional)
Tetsuo Noda (additional)
Hidenori Ichijo (additional)

References 30 Referenced 1,027

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 6:50 p.m.)
Deposited	1 year, 8 months ago (Dec. 18, 2023, 3:54 p.m.)
Indexed	26 minutes ago (Aug. 29, 2025, 3:44 a.m.)
Issued	24 years, 5 months ago (March 1, 2001)
Published	24 years, 5 months ago (March 1, 2001)
Published Online	24 years, 5 months ago (March 1, 2001)
Published Print	24 years, 5 months ago (March 1, 2001)

Funders 0

None

BibTeX

@article{Tobiume_2001, title={ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis}, volume={2}, ISSN={1469-3178}, url={http://dx.doi.org/10.1093/embo-reports/kve046}, DOI={10.1093/embo-reports/kve046}, number={3}, journal={EMBO reports}, publisher={Springer Science and Business Media LLC}, author={Tobiume, Kei and Matsuzawa, Atsushi and Takahashi, Takumi and Nishitoh, Hideki and Morita, Kei‐ichi and Takeda, Kohsuke and Minowa, Osamu and Miyazono, Kohei and Noda, Tetsuo and Ichijo, Hidenori}, year={2001}, month=mar, pages={222–228} }

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