Abstract
Cdc7/Dbf4 is a protein kinase that is required for the initiation of DNA replication in eukaryotes. Recent work has provided new clues to the role that Cdc7/Dbf4 plays in this process. A range of other observations suggest that Cdc7/Dbf4 also plays another, less well characterized, role in checkpoint function and in the maintenance of genomic integrity. In this review we attempt to bring together new information to explain how Cdc7/Dbf4 may perform these two distinct functions.
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Dates
Type | When |
---|---|
Created | 23 years, 1 month ago (July 26, 2002, 6:48 p.m.) |
Deposited | 1 year, 8 months ago (Dec. 18, 2023, 3:54 p.m.) |
Indexed | 4 months, 2 weeks ago (April 16, 2025, 11:26 a.m.) |
Issued | 24 years, 11 months ago (Oct. 1, 2000) |
Published | 24 years, 11 months ago (Oct. 1, 2000) |
Published Online | 24 years, 11 months ago (Oct. 1, 2000) |
Published Print | 24 years, 11 months ago (Oct. 1, 2000) |
@article{Jares_2000, title={The Cdc7/Dbf4 protein kinase: target of the S phase checkpoint?}, volume={1}, ISSN={1469-3178}, url={http://dx.doi.org/10.1093/embo-reports/kvd076}, DOI={10.1093/embo-reports/kvd076}, number={4}, journal={EMBO reports}, publisher={Springer Science and Business Media LLC}, author={Jares, Pedro and Donaldson, Anne and Blow, J Julian}, year={2000}, month=oct, pages={319–322} }