DOI: 10.1093/cvr/cvp015. MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue

MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue

10.1093/cvr/cvp015

Crossref journal-article

Oxford University Press (OUP)

Cardiovascular Research (286)

Bibliography

Roy, S., Khanna, S., Hussain, S.-R. A., Biswas, S., Azad, A., Rink, C., Gnyawali, S., Shilo, S., Nuovo, G. J., & Sen, C. K. (2009). MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue. Cardiovascular Research, 82(1), 21â29.

Authors 10

Sashwati Roy (first)
Savita Khanna (additional)
Syed-Rehan A. Hussain (additional)
Sabyasachi Biswas (additional)
Ali Azad (additional)
Cameron Rink (additional)
Surya Gnyawali (additional)
Shani Shilo (additional)
Gerard J. Nuovo (additional)
Chandan K. Sen (additional)

References 35 Referenced 506

10.2741/2865 / Front Biosci / Protein interactions and complexes in human microRNA biogenesis and function by Perron (2008)
10.1161/CIRCRESAHA.107.156786 / Circ Res / STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted mES transplantation in a mouse model of myocardial infarction by Rajasingh (2007)
10.1161/ATVBAHA.107.160655 / Arterioscler Thromb Vasc Biol / Evidence for the involvement of miRNA in redox regulated angiogenic response of human microvascular endothelial cells by Shilo (2008)
10.1161/01.RES.0000056770.30922.E6 / Circ Res / Oxygen sensing by primary cardiac fibroblasts: a key role of p21(Waf1/Cip1/Sdi1) by Roy (2003)
10.1091/mbc.E07-03-0270 / Mol Biol Cell / p21waf1/cip1/sdi1 as a central regulator of inducible smooth muscle actin expression and differentiation of cardiac fibroblasts to myofibroblasts by Roy (2007)
10.1074/jbc.M308703200 / J Biol Chem / Characterization of perceived hyperoxia in isolated primary cardiac fibroblasts and in the reoxygenated heart by Roy (2003)
10.1152/ajpheart.01190.2007 / Am J Physiol Heart Circ Physiol / Characterization of the structural and functional changes in the myocardium following focal ischemia-reperfusion injury by Ojha (2008)
10.1038/sj.onc.1210083 / Oncogene / miR-21-mediated tumor growth by Si (2007)
10.1152/ajpheart.01346.2005 / Am J Physiol Heart Circ Physiol / Laser microdissection and pressure-catapulting technique to study gene expression in the reoxygenated myocardium by Kuhn (2006)
10.1152/physiolgenomics.00013.2006 / Physiol Genomics / Transcriptome analysis of the ischemia-reperfused remodeling myocardium: temporal changes in inflammation and extracellular matrix by Roy (2006)
10.1073/pnas.0706793104 / Proc Natl Acad Sci USA / Transcriptome-wide analysis of blood vessels laser captured from human skin and chronic wound-edge tissue by Roy (2007)
10.1152/ajpheart.01069.2006 / Am J Physiol Heart Circ Physiol / Laser microdissection and capture of pure cardiomyocytes and fibroblasts from infarcted heart regions: perceived hyperoxia induces P21 in peri-infarct myocytes by Kuhn (2007)
10.1016/j.ymeth.2007.10.008 / Methods / In situ detection of precursor and mature microRNAs in paraffin embedded, formalin fixed tissues and cell preparations by Nuovo (2008)
10.1016/j.cardiores.2006.01.003 / Cardiovasc Res / Perceived hyperoxia: oxygen-induced remodeling of the reoxygenated heart by Sen (2006)
10.1016/S0076-6879(06)11002-2 / Methods Enzymol / Analyzing micro-RNA expression using microarrays by Davison (2006)
10.1073/pnas.95.25.14863 / Proc Natl Acad Sci USA / Cluster analysis and display of genome-wide expression patterns by Eisen (1998)
10.1053/j.gastro.2007.05.022 / Gastroenterology / MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer by Meng (2007)
10.1038/sj.bjp.0707155 / Br J Pharmacol / PTEN, the Achilles’ heel of myocardial ischaemia/reperfusion injury? by Mocanu (2007)
10.1016/j.yjmcc.2004.05.015 / J Mol Cell Cardiol / The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease by Oudit (2004)
10.1038/nature03702 / Nature / MicroRNA expression profiles classify human cancers by Lu (2005)
10.1073/pnas.0608791103 / Proc Natl Acad Sci USA / A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure by van Rooij (2006)
10.1042/BST0350257 / Biochem Soc Trans / Inhibiting PTEN by Rosivatz (2007)
10.1016/j.pharmthera.2006.06.001 / Pharmacol Ther / Lipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesity by Sasaoka (2006)
{'key': 'key\n\t\t\t\t20170518141745_CVP015C24', 'article-title': 'Activation and modulation of 72 kDa matrix metalloproteinase-2 by peroxynitrite and glutathione', 'author': 'Viappiani', 'year': '2008', 'journal-title': 'Biochem Pharmacol'} / Biochem Pharmacol / Activation and modulation of 72 kDa matrix metalloproteinase-2 by peroxynitrite and glutathione by Viappiani (2008)
10.1161/01.CIR.101.15.1833 / Circulation / Matrix metalloproteinase-2 contributes to ischemia-reperfusion injury in the heart by Cheung (2000)
10.1016/j.cardiores.2005.08.023 / Cardiovasc Res / Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility by Wang (2006)
10.1016/j.bbrc.2007.04.094 / Biochem Biophys Res Commun / Transgenic MMP-2 expression induces latent cardiac mitochondrial dysfunction by Zhou (2007)
10.1016/j.yjmcc.2007.07.055 / J Mol Cell Cardiol / Matrix metalloproteinase-2 degrades the cytoskeletal protein alpha-actinin in peroxynitrite mediated myocardial injury by Sung (2007)
{'key': 'key\n\t\t\t\t20170518141745_CVP015C29', 'first-page': '6318', 'article-title': 'PTEN suppresses hyaluronic acid-induced matrix metalloproteinase-9 expression in U87MG glioblastoma cells through focal adhesion kinase dephosphorylation', 'volume': '62', 'author': 'Park', 'year': '2002', 'journal-title': 'Cancer Res'} / Cancer Res / PTEN suppresses hyaluronic acid-induced matrix metalloproteinase-9 expression in U87MG glioblastoma cells through focal adhesion kinase dephosphorylation by Park (2002)
{'key': 'key\n\t\t\t\t20170518141745_CVP015C30', 'first-page': '3579', 'article-title': 'Expressions of MMP-2, MMP-9 and VEGF are closely linked to growth, invasion, metastasis and angiogenesis of gastric carcinoma', 'volume': '26', 'author': 'Zheng', 'year': '2006', 'journal-title': 'Anticancer Res'} / Anticancer Res / Expressions of MMP-2, MMP-9 and VEGF are closely linked to growth, invasion, metastasis and angiogenesis of gastric carcinoma by Zheng (2006)
{'key': 'key\n\t\t\t\t20170518141745_CVP015C31', 'first-page': '73', 'article-title': 'PTEN gene transfer suppresses the invasive potential of human malignant gliomas by regulating cell invasion-related molecules', 'volume': '29', 'author': 'Furukawa', 'year': '2006', 'journal-title': 'Int J Oncol'} / Int J Oncol / PTEN gene transfer suppresses the invasive potential of human malignant gliomas by regulating cell invasion-related molecules by Furukawa (2006)
10.1074/jbc.M701081200 / J Biol Chem / Nerve growth factor induces endothelial cell invasion and cord formation by promoting matrix metalloproteinase-2 expression through the phosphatidylinositol 3-kinase/Akt signaling pathway and AP-2 transcription factor by Park (2007)
10.1158/0008-5472.CAN-05-4340 / Cancer Res / Ionizing radiation enhances matrix metalloproteinase-2 secretion and invasion of glioma cells through Src/epidermal growth factor receptor-mediated p38/Akt and phosphatidylinositol 3-kinase/Akt signaling pathways by Park (2006)
10.1038/nature07511 / Nature / MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts by Thum (2008)
10.1016/j.febslet.2008.11.014 / FEBS Lett / Endogenous microRNAs induced by heat-shock reduce myocardial infarction following ischemia–reperfusion in mice by Yin (2008)

Dates

Type	When
Created	16 years, 7 months ago (Jan. 15, 2009, 3:39 p.m.)
Deposited	8 years ago (Aug. 22, 2017, 4:32 p.m.)
Indexed	1 week, 2 days ago (Aug. 27, 2025, 12:21 p.m.)
Issued	16 years, 7 months ago (Jan. 15, 2009)
Published	16 years, 7 months ago (Jan. 15, 2009)
Published Online	16 years, 7 months ago (Jan. 15, 2009)
Published Print	16 years, 5 months ago (April 1, 2009)

Funders 0

None

BibTeX

@article{Roy_2009, title={MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue}, volume={82}, ISSN={0008-6363}, url={http://dx.doi.org/10.1093/cvr/cvp015}, DOI={10.1093/cvr/cvp015}, number={1}, journal={Cardiovascular Research}, publisher={Oxford University Press (OUP)}, author={Roy, Sashwati and Khanna, Savita and Hussain, Syed-Rehan A. and Biswas, Sabyasachi and Azad, Ali and Rink, Cameron and Gnyawali, Surya and Shilo, Shani and Nuovo, Gerard J. and Sen, Chandan K.}, year={2009}, month=jan, pages={21–29} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        27
      ]
    ],
    "date-time": "2025-08-27T16:21:00Z",
    "timestamp": 1756311660054
  },
  "reference-count": 35,
  "publisher": "Oxford University Press (OUP)",
  "issue": "1",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2009,
        4,
        1
      ]
    ]
  },
  "DOI": "10.1093/cvr/cvp015",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2009,
        1,
        15
      ]
    ],
    "date-time": "2009-01-15T20:39:21Z",
    "timestamp": 1232051961000
  },
  "page": "21-29",
  "source": "Crossref",
  "is-referenced-by-count": 506,
  "title": "MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue",
  "prefix": "10.1093",
  "volume": "82",
  "author": [
    {
      "given": "Sashwati",
      "family": "Roy",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Savita",
      "family": "Khanna",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Syed-Rehan A.",
      "family": "Hussain",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Sabyasachi",
      "family": "Biswas",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Ali",
      "family": "Azad",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Cameron",
      "family": "Rink",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Surya",
      "family": "Gnyawali",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Shani",
      "family": "Shilo",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Gerard J.",
      "family": "Nuovo",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Chandan K.",
      "family": "Sen",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "286",
  "published-online": {
    "date-parts": [
      [
        2009,
        1,
        15
      ]
    ]
  },
  "reference": [
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C1",
      "doi-asserted-by": "crossref",
      "first-page": "2537",
      "DOI": "10.2741/2865",
      "article-title": "Protein interactions and complexes in human microRNA biogenesis and function",
      "volume": "13",
      "author": "Perron",
      "year": "2008",
      "journal-title": "Front Biosci"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C2",
      "doi-asserted-by": "crossref",
      "first-page": "910",
      "DOI": "10.1161/CIRCRESAHA.107.156786",
      "article-title": "STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted mES transplantation in a mouse model of myocardial infarction",
      "volume": "101",
      "author": "Rajasingh",
      "year": "2007",
      "journal-title": "Circ Res"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C3",
      "doi-asserted-by": "crossref",
      "first-page": "471",
      "DOI": "10.1161/ATVBAHA.107.160655",
      "article-title": "Evidence for the involvement of miRNA in redox regulated angiogenic response of human microvascular endothelial cells",
      "volume": "28",
      "author": "Shilo",
      "year": "2008",
      "journal-title": "Arterioscler Thromb Vasc Biol"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C4",
      "doi-asserted-by": "crossref",
      "first-page": "264",
      "DOI": "10.1161/01.RES.0000056770.30922.E6",
      "article-title": "Oxygen sensing by primary cardiac fibroblasts: a key role of p21(Waf1/Cip1/Sdi1)",
      "volume": "92",
      "author": "Roy",
      "year": "2003",
      "journal-title": "Circ Res"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C5",
      "doi-asserted-by": "crossref",
      "first-page": "4837",
      "DOI": "10.1091/mbc.E07-03-0270",
      "article-title": "p21waf1/cip1/sdi1 as a central regulator of inducible smooth muscle actin expression and differentiation of cardiac fibroblasts to myofibroblasts",
      "volume": "18",
      "author": "Roy",
      "year": "2007",
      "journal-title": "Mol Biol Cell"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C6",
      "doi-asserted-by": "crossref",
      "first-page": "47129",
      "DOI": "10.1074/jbc.M308703200",
      "article-title": "Characterization of perceived hyperoxia in isolated primary cardiac fibroblasts and in the reoxygenated heart",
      "volume": "278",
      "author": "Roy",
      "year": "2003",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C7",
      "doi-asserted-by": "crossref",
      "first-page": "H2435",
      "DOI": "10.1152/ajpheart.01190.2007",
      "article-title": "Characterization of the structural and functional changes in the myocardium following focal ischemia-reperfusion injury",
      "volume": "294",
      "author": "Ojha",
      "year": "2008",
      "journal-title": "Am J Physiol Heart Circ Physiol"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C8",
      "doi-asserted-by": "crossref",
      "first-page": "2799",
      "DOI": "10.1038/sj.onc.1210083",
      "article-title": "miR-21-mediated tumor growth",
      "volume": "26",
      "author": "Si",
      "year": "2007",
      "journal-title": "Oncogene"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C9",
      "doi-asserted-by": "crossref",
      "first-page": "H2625",
      "DOI": "10.1152/ajpheart.01346.2005",
      "article-title": "Laser microdissection and pressure-catapulting technique to study gene expression in the reoxygenated myocardium",
      "volume": "290",
      "author": "Kuhn",
      "year": "2006",
      "journal-title": "Am J Physiol Heart Circ Physiol"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C10",
      "doi-asserted-by": "crossref",
      "first-page": "364",
      "DOI": "10.1152/physiolgenomics.00013.2006",
      "article-title": "Transcriptome analysis of the ischemia-reperfused remodeling myocardium: temporal changes in inflammation and extracellular matrix",
      "volume": "25",
      "author": "Roy",
      "year": "2006",
      "journal-title": "Physiol Genomics"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C11",
      "doi-asserted-by": "crossref",
      "first-page": "14472",
      "DOI": "10.1073/pnas.0706793104",
      "article-title": "Transcriptome-wide analysis of blood vessels laser captured from human skin and chronic wound-edge tissue",
      "volume": "104",
      "author": "Roy",
      "year": "2007",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C12",
      "doi-asserted-by": "crossref",
      "first-page": "H1245",
      "DOI": "10.1152/ajpheart.01069.2006",
      "article-title": "Laser microdissection and capture of pure cardiomyocytes and fibroblasts from infarcted heart regions: perceived hyperoxia induces P21 in peri-infarct myocytes",
      "volume": "292",
      "author": "Kuhn",
      "year": "2007",
      "journal-title": "Am J Physiol Heart Circ Physiol"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C13",
      "doi-asserted-by": "crossref",
      "first-page": "39",
      "DOI": "10.1016/j.ymeth.2007.10.008",
      "article-title": "In situ detection of precursor and mature microRNAs in paraffin embedded, formalin fixed tissues and cell preparations",
      "volume": "44",
      "author": "Nuovo",
      "year": "2008",
      "journal-title": "Methods"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C14",
      "doi-asserted-by": "crossref",
      "first-page": "280",
      "DOI": "10.1016/j.cardiores.2006.01.003",
      "article-title": "Perceived hyperoxia: oxygen-induced remodeling of the reoxygenated heart",
      "volume": "71",
      "author": "Sen",
      "year": "2006",
      "journal-title": "Cardiovasc Res"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C15",
      "doi-asserted-by": "crossref",
      "first-page": "14",
      "DOI": "10.1016/S0076-6879(06)11002-2",
      "article-title": "Analyzing micro-RNA expression using microarrays",
      "volume": "411",
      "author": "Davison",
      "year": "2006",
      "journal-title": "Methods Enzymol"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C16",
      "doi-asserted-by": "crossref",
      "first-page": "14863",
      "DOI": "10.1073/pnas.95.25.14863",
      "article-title": "Cluster analysis and display of genome-wide expression patterns",
      "volume": "95",
      "author": "Eisen",
      "year": "1998",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C17",
      "doi-asserted-by": "crossref",
      "first-page": "647",
      "DOI": "10.1053/j.gastro.2007.05.022",
      "article-title": "MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer",
      "volume": "133",
      "author": "Meng",
      "year": "2007",
      "journal-title": "Gastroenterology"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C18",
      "doi-asserted-by": "crossref",
      "first-page": "833",
      "DOI": "10.1038/sj.bjp.0707155",
      "article-title": "PTEN, the Achilles\u2019 heel of myocardial ischaemia/reperfusion injury?",
      "volume": "150",
      "author": "Mocanu",
      "year": "2007",
      "journal-title": "Br J Pharmacol"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C19",
      "doi-asserted-by": "crossref",
      "first-page": "449",
      "DOI": "10.1016/j.yjmcc.2004.05.015",
      "article-title": "The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease",
      "volume": "37",
      "author": "Oudit",
      "year": "2004",
      "journal-title": "J Mol Cell Cardiol"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C20",
      "doi-asserted-by": "crossref",
      "first-page": "834",
      "DOI": "10.1038/nature03702",
      "article-title": "MicroRNA expression profiles classify human cancers",
      "volume": "435",
      "author": "Lu",
      "year": "2005",
      "journal-title": "Nature"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C21",
      "doi-asserted-by": "crossref",
      "first-page": "18255",
      "DOI": "10.1073/pnas.0608791103",
      "article-title": "A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure",
      "volume": "103",
      "author": "van Rooij",
      "year": "2006",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C22",
      "doi-asserted-by": "crossref",
      "first-page": "257",
      "DOI": "10.1042/BST0350257",
      "article-title": "Inhibiting PTEN",
      "volume": "35",
      "author": "Rosivatz",
      "year": "2007",
      "journal-title": "Biochem Soc Trans"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C23",
      "doi-asserted-by": "crossref",
      "first-page": "799",
      "DOI": "10.1016/j.pharmthera.2006.06.001",
      "article-title": "Lipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesity",
      "volume": "112",
      "author": "Sasaoka",
      "year": "2006",
      "journal-title": "Pharmacol Ther"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C24",
      "article-title": "Activation and modulation of 72 kDa matrix metalloproteinase-2 by peroxynitrite and glutathione",
      "author": "Viappiani",
      "year": "2008",
      "journal-title": "Biochem Pharmacol"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C25",
      "doi-asserted-by": "crossref",
      "first-page": "1833",
      "DOI": "10.1161/01.CIR.101.15.1833",
      "article-title": "Matrix metalloproteinase-2 contributes to ischemia-reperfusion injury in the heart",
      "volume": "101",
      "author": "Cheung",
      "year": "2000",
      "journal-title": "Circulation"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C26",
      "doi-asserted-by": "crossref",
      "first-page": "688",
      "DOI": "10.1016/j.cardiores.2005.08.023",
      "article-title": "Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility",
      "volume": "69",
      "author": "Wang",
      "year": "2006",
      "journal-title": "Cardiovasc Res"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C27",
      "doi-asserted-by": "crossref",
      "first-page": "189",
      "DOI": "10.1016/j.bbrc.2007.04.094",
      "article-title": "Transgenic MMP-2 expression induces latent cardiac mitochondrial dysfunction",
      "volume": "358",
      "author": "Zhou",
      "year": "2007",
      "journal-title": "Biochem Biophys Res Commun"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C28",
      "doi-asserted-by": "crossref",
      "first-page": "429",
      "DOI": "10.1016/j.yjmcc.2007.07.055",
      "article-title": "Matrix metalloproteinase-2 degrades the cytoskeletal protein alpha-actinin in peroxynitrite mediated myocardial injury",
      "volume": "43",
      "author": "Sung",
      "year": "2007",
      "journal-title": "J Mol Cell Cardiol"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C29",
      "first-page": "6318",
      "article-title": "PTEN suppresses hyaluronic acid-induced matrix metalloproteinase-9 expression in U87MG glioblastoma cells through focal adhesion kinase dephosphorylation",
      "volume": "62",
      "author": "Park",
      "year": "2002",
      "journal-title": "Cancer Res"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C30",
      "first-page": "3579",
      "article-title": "Expressions of MMP-2, MMP-9 and VEGF are closely linked to growth, invasion, metastasis and angiogenesis of gastric carcinoma",
      "volume": "26",
      "author": "Zheng",
      "year": "2006",
      "journal-title": "Anticancer Res"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C31",
      "first-page": "73",
      "article-title": "PTEN gene transfer suppresses the invasive potential of human malignant gliomas by regulating cell invasion-related molecules",
      "volume": "29",
      "author": "Furukawa",
      "year": "2006",
      "journal-title": "Int J Oncol"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C32",
      "doi-asserted-by": "crossref",
      "first-page": "30485",
      "DOI": "10.1074/jbc.M701081200",
      "article-title": "Nerve growth factor induces endothelial cell invasion and cord formation by promoting matrix metalloproteinase-2 expression through the phosphatidylinositol 3-kinase/Akt signaling pathway and AP-2 transcription factor",
      "volume": "282",
      "author": "Park",
      "year": "2007",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C33",
      "doi-asserted-by": "crossref",
      "first-page": "8511",
      "DOI": "10.1158/0008-5472.CAN-05-4340",
      "article-title": "Ionizing radiation enhances matrix metalloproteinase-2 secretion and invasion of glioma cells through Src/epidermal growth factor receptor-mediated p38/Akt and phosphatidylinositol 3-kinase/Akt signaling pathways",
      "volume": "66",
      "author": "Park",
      "year": "2006",
      "journal-title": "Cancer Res"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C34",
      "doi-asserted-by": "crossref",
      "first-page": "980",
      "DOI": "10.1038/nature07511",
      "article-title": "MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts",
      "volume": "456",
      "author": "Thum",
      "year": "2008",
      "journal-title": "Nature"
    },
    {
      "key": "key\n\t\t\t\t20170518141745_CVP015C35",
      "doi-asserted-by": "crossref",
      "first-page": "4137",
      "DOI": "10.1016/j.febslet.2008.11.014",
      "article-title": "Endogenous microRNAs induced by heat-shock reduce myocardial infarction following ischemia\u2013reperfusion in mice",
      "volume": "582",
      "author": "Yin",
      "year": "2008",
      "journal-title": "FEBS Lett"
    }
  ],
  "container-title": "Cardiovascular Research",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://academic.oup.com/cardiovascres/article-pdf/82/1/21/17197638/cvp015.pdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2017,
        8,
        22
      ]
    ],
    "date-time": "2017-08-22T20:32:56Z",
    "timestamp": 1503433976000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://academic.oup.com/cardiovascres/article-lookup/doi/10.1093/cvr/cvp015"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2009,
        1,
        15
      ]
    ]
  },
  "references-count": 35,
  "journal-issue": {
    "issue": "1",
    "published-online": {
      "date-parts": [
        [
          2009,
          1,
          15
        ]
      ]
    },
    "published-print": {
      "date-parts": [
        [
          2009,
          4,
          1
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1093/cvr/cvp015",
  "relation": {},
  "ISSN": [
    "1755-3245",
    "0008-6363"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        2009,
        1,
        15
      ]
    ]
  }
}