DOI: 10.1093/clinchem/44.12.2422. Identification of urinary oligosaccharides by matrix-assisted laser desorption ionization time-of-flight mass spectrometry

Identification of urinary oligosaccharides by matrix-assisted laser desorption ionization time-of-flight mass spectrometry

10.1093/clinchem/44.12.2422

Crossref journal-article

Oxford University Press (OUP)

Clinical Chemistry (286)

Abstract

AbstractA new method of urinary oligosaccharides identification by matrix-assisted laser desorption time-of-flight mass spectrometry is presented. The method involves three steps: coupling of the urinary oligosaccharides with 8-aminonaphthalene-1,3,6-trisulfonic acid; fast purification over a porous graphite carbon extraction column; and mass spectrometric analysis. Identification of urinary oligosaccharides is based on the patterns and values of the pseudomolecular ions observed. We report here the patterns in urines from patients with Pompe disease, alpha and beta mannosidoses, galacto-sialidosis, and GM1 gangliosidosis. The protocols described here allowed facile and sensitive identification of the pathognomonic oligosacchariduria present in lysosomal diseases and can be extended to any pathological oligosacchariduria.

Bibliography

Klein, A., Lebreton, A., Lemoine, J., PeÌrini, J.-M., Roussel, P., & Michalski, J.-C. (1998). Identification of urinary oligosaccharides by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Clinical Chemistry, 44(12), 2422â2428.

Authors 6

André Klein (first)
Alexandra Lebreton (first)
Jérome Lemoine (first)
Jean-Marc Périni (first)
Philippe Roussel (first)
Jean-Claude Michalski (first)

References 22 Referenced 36

10.1016/0076-6879(78)50025-6 / Methods Enzymol (1978)
10.1016/0009-8981(88)90172-6 / Clin Chim Acta (1988)
10.1093/clinchem/39.11.2346 / Clin Chem (1993)
10.1111/j.1651-2227.1996.tb14095.x / Acta Paedriatr (1996)
10.1016/0009-8981(79)90221-3 / Clin Chim Acta (1979)
{'key': '2020022904242515200_R6', 'first-page': '55', 'year': '1996', 'journal-title': 'Glycoproteins and disease'} / Glycoproteins and disease (1996)
10.1016/0009-8981(91)90293-L / Clin Chim Acta (1991)
10.1093/clinchem/40.6.914 / Clin Chem (1994)
10.1042/bj2700705 / Biochem J (1990)
10.1007/BF00902189 / Glycosylation Dis (1994)
10.1016/0076-6879(94)30019-4 / Methods Enzymol (1994)
10.1073/pnas.89.14.6338 / Proc Natl Acad Sci U S A (1992)
10.1111/j.1432-1033.1991.tb16045.x / Eur J Biochem (1991)
{'key': '2020022904242515200_R14', 'first-page': '255', 'volume': '230', 'year': '1994', 'journal-title': 'Methods Enzymol'} / Methods Enzymol (1994)
10.1023/A:1006907724915 / Glycoconj J (1998)
10.1038/227680a0 / Nature (1970)
10.1016/0014-5793(80)81269-5 / FEBS Lett (1980)
10.1111/j.1432-1033.1994.tb18628.x / Eur J Biochem (1994)
10.1002/(SICI)1520-6343(1997)3:4<259::AID-BSPY2>3.0.CO;2-# / Biospectroscopy (1997)
10.1016/0959-440X(95)80063-8 / Curr Opin Struct Biol (1995)
10.1056/NEJM198906293202606 / N Engl J Med (1989)
10.1016/0009-8981(84)90310-3 / Clin Chim Acta (1984)

Dates

Type	When
Created	5 years, 7 months ago (Jan. 23, 2020, 1:51 a.m.)
Deposited	1 year, 11 months ago (Sept. 25, 2023, 10:30 a.m.)
Indexed	4 months, 3 weeks ago (April 7, 2025, 1:05 p.m.)
Issued	26 years, 9 months ago (Dec. 1, 1998)
Published	26 years, 9 months ago (Dec. 1, 1998)
Published Online	26 years, 9 months ago (Dec. 1, 1998)
Published Print	26 years, 9 months ago (Dec. 1, 1998)

Funders 0

None

BibTeX

@article{Klein_1998, title={Identification of urinary oligosaccharides by matrix-assisted laser desorption ionization time-of-flight mass spectrometry}, volume={44}, ISSN={1530-8561}, url={http://dx.doi.org/10.1093/clinchem/44.12.2422}, DOI={10.1093/clinchem/44.12.2422}, number={12}, journal={Clinical Chemistry}, publisher={Oxford University Press (OUP)}, author={Klein, André and Lebreton, Alexandra and Lemoine, Jérome and Périni, Jean-Marc and Roussel, Philippe and Michalski, Jean-Claude}, year={1998}, month=dec, pages={2422–2428} }

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