DOI: 10.1093/carcin/8.4.527. Induction of oral cavity cancer by 3-diazotyramine, a nitrosated product of tyramine present in foods

Induction of oral cavity cancer by 3-diazotyramine, a nitrosated product of tyramine present in foods

10.1093/carcin/8.4.527

Crossref journal-article

Oxford University Press (OUP)

Carcinogenesis (286)

Abstract

Abstract A mutagenic nitrosation product of tyramine, 4-(2-amino-ethyl)-6-diazo-2,4-cydobexadienone (3-diazotyramine, 3-DT) preferentially induced tumors of the oral cavity. Squamous-cell carcinomas of the mucosa of the oral cavity floor developed in 19 out of 28 male F344 rats administered 0.1% 3-DT in their drinking water. Tyramine and nitrite are found at fairly high concentrations in various foods. This demonstration of the carcinogenicity of 3-DT indicates that although the implications of 3-DT for human cancer are not clear, other nitrosable mutagen precursors need to be tested as possible risk factors in human cancer.

Bibliography

Fujita, Y., Wakabayashi, K., Takayama, S., Nagao, M., & Sugimura, T. (1987). Induction of oral cavity cancer by 3-diazotyramine, a nitrosated product of tyramine present in foods. Carcinogenesis, 8(4), 527â529.

Authors 5

Yuki Fujita (first)
Keiji Wakabayashi (additional)
Shozo Takayama (additional)
Minako Nagao (additional)
Takashi Sugimura (additional)

References 0 Referenced 21

None

Dates

Type	When
Created	18 years, 8 months ago (Jan. 4, 2007, 9:17 a.m.)
Deposited	1 year, 5 months ago (March 27, 2024, 11:53 a.m.)
Indexed	1 year, 5 months ago (March 27, 2024, 12:10 p.m.)
Issued	38 years, 5 months ago (April 1, 1987)
Published	38 years, 5 months ago (April 1, 1987)
Published Online	38 years, 5 months ago (April 1, 1987)
Published Print	38 years, 5 months ago (April 1, 1987)

Funders 0

None

BibTeX

@article{Fujita_1987, title={Induction of oral cavity cancer by 3-diazotyramine, a nitrosated product of tyramine present in foods}, volume={8}, ISSN={0143-3334}, url={http://dx.doi.org/10.1093/carcin/8.4.527}, DOI={10.1093/carcin/8.4.527}, number={4}, journal={Carcinogenesis}, publisher={Oxford University Press (OUP)}, author={Fujita, Yuki and Wakabayashi, Keiji and Takayama, Shozo and Nagao, Minako and Sugimura, Takashi}, year={1987}, month=apr, pages={527–529} }

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