DOI: 10.1093/bioinformatics/btr175. Proteins without 3D structure: definition, detection and beyond

Proteins without 3D structure: definition, detection and beyond

10.1093/bioinformatics/btr175

Crossref journal-article

Oxford University Press (OUP)

Bioinformatics (286)

Abstract

Abstract Motivation: Predictions, and experiments to a lesser extent, following the decoding of the human genome showed that a significant fraction of gene products do not have well-defined 3D structures. While the presence of structured domains traditionally suggested function, it was not clear what the absence of structure implied. These and many other findings initiated the extensive theoretical and experimental research into these types of proteins, commonly known as intrinsically disordered proteins (IDPs). Crucial to understanding IDPs is the evaluation of structural predictors based on different principles and trained on various datasets, which is currently the subject of active research. The view is emerging that structural disorder can be considered as a separate structural category and not simply as absence of secondary and/or tertiary structure. IDPs perform essential functions and their improper functioning is responsible for human diseases such as neurodegenerative disorders. Contact: ovadi@enzim.hu Supplementary information: Supplementary data are available at Bioinformatics online.

Bibliography

Orosz, F., & OvÃ¡di, J. (2011). Proteins without 3D structure: definition, detection and beyond. Bioinformatics, 27(11), 1449â1454.

Authors 2

Ferenc Orosz (first)
Judit Ovádi (additional)

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Dates

Type	When
Created	14 years, 4 months ago (April 14, 2011, 8:50 p.m.)
Deposited	2 years, 7 months ago (Jan. 25, 2023, 6:23 a.m.)
Indexed	4 months, 3 weeks ago (April 9, 2025, 8:32 a.m.)
Issued	14 years, 4 months ago (April 14, 2011)
Published	14 years, 4 months ago (April 14, 2011)
Published Online	14 years, 4 months ago (April 14, 2011)
Published Print	14 years, 3 months ago (June 1, 2011)

Funders 0

None

BibTeX

@article{Orosz_2011, title={Proteins without 3D structure: definition, detection and beyond}, volume={27}, ISSN={1367-4803}, url={http://dx.doi.org/10.1093/bioinformatics/btr175}, DOI={10.1093/bioinformatics/btr175}, number={11}, journal={Bioinformatics}, publisher={Oxford University Press (OUP)}, author={Orosz, Ferenc and Ovádi, Judit}, year={2011}, month=apr, pages={1449–1454} }

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