Abstract
Abstract Motivation: InterPro is a new integrated documentation resource for protein families, domains and functional sites, developed initially as a means of rationalising the complementary efforts of the PROSITE, PRINTS, Pfam and ProDom database projects. Results: Merged annotations from PRINTS, PROSITE and Pfam form the InterPro core. Each combined InterPro entry includes functional descriptions and literature references, and links are made back to the relevant parent database(s), allowing users to see at a glance whether a particular family or domain has associated patterns, profiles, fingerprints, etc. Merged and individual entries (i.e. those that have no counterpart in the companion resources) are assigned unique accession numbers. Release 1.2 of InterPro (June 2000) contains over 3000 entries, representing families, domains, repeats and sites of post-translational modification (PTMs) encoded by 6581 different regular expressions, profiles, fingerprints and Hidden Markov Models (HMMs). Each InterPro entry lists all the matches against SWISS-PROT and TrEMBL (more than 1000000 hits from 264333 different proteins out of 384572 in SWISS-PROT and TrEMBL). Availability: The database is accessible for text- and sequence-based searches at http://www.ebi.ac.uk/interpro/. Contact: Interhelp@ebi.ac.uk * To whom correspondence should be addressed.
Bibliography
Apweiler, R., Attwood, T. K., Bairoch, A., Bateman, A., Birney, E., Biswas, M., Bucher, P., Cerutti, L., Corpet, F., Croning, M. D. R., Durbin, R., Falquet, L., Fleischmann, W., Gouzy, J., Hermjakob, H., Hulo, N., Jonassen, I., Kahn, D., Kanapin, A., ⦠Zdobnov, E. M. (2000). InterProâan integrated documentation resource for protein families, domains and functional sites. Bioinformatics, 16(12), 1145â1150.
Authors
28
- R. Apweiler (first)
- T. K. Attwood (additional)
- A. Bairoch (additional)
- A. Bateman (additional)
- E. Birney (additional)
- M. Biswas (additional)
- P. Bucher (additional)
- L. Cerutti (additional)
- F. Corpet (additional)
- M. D. R. Croning (additional)
- R. Durbin (additional)
- L. Falquet (additional)
- W. Fleischmann (additional)
- J. Gouzy (additional)
- H. Hermjakob (additional)
- N. Hulo (additional)
- I. Jonassen (additional)
- D. Kahn (additional)
- A. Kanapin (additional)
- Y. Karavidopoulou (additional)
- R. Lopez (additional)
- B. Marx (additional)
- N. J. Mulder (additional)
- T. M. Oinn (additional)
- M. Pagni (additional)
- F. Servant (additional)
- C. J. A. Sigrist (additional)
- E. M. Zdobnov (additional)
Dates
| Type | When |
|---|---|
| Created | 23 years, 1 month ago (July 26, 2002, 6:48 p.m.) |
| Deposited | 2 years, 7 months ago (Jan. 24, 2023, 1:24 a.m.) |
| Indexed | 1 month, 3 weeks ago (July 11, 2025, 6:52 a.m.) |
| Issued | 24 years, 9 months ago (Dec. 1, 2000) |
| Published | 24 years, 9 months ago (Dec. 1, 2000) |
| Published Online | 24 years, 9 months ago (Dec. 1, 2000) |
| Published Print | 24 years, 9 months ago (Dec. 1, 2000) |
@article{Apweiler_2000, title={InterPro—an integrated documentation resource for protein families, domains and functional sites}, volume={16}, ISSN={1367-4803}, url={http://dx.doi.org/10.1093/bioinformatics/16.12.1145}, DOI={10.1093/bioinformatics/16.12.1145}, number={12}, journal={Bioinformatics}, publisher={Oxford University Press (OUP)}, author={Apweiler, R. and Attwood, T. K. and Bairoch, A. and Bateman, A. and Birney, E. and Biswas, M. and Bucher, P. and Cerutti, L. and Corpet, F. and Croning, M. D. R. and Durbin, R. and Falquet, L. and Fleischmann, W. and Gouzy, J. and Hermjakob, H. and Hulo, N. and Jonassen, I. and Kahn, D. and Kanapin, A. and Karavidopoulou, Y. and Lopez, R. and Marx, B. and Mulder, N. J. and Oinn, T. M. and Pagni, M. and Servant, F. and Sigrist, C. J. A. and Zdobnov, E. M.}, year={2000}, month=dec, pages={1145–1150} }