DOI: 10.1093/annonc/12.suppl_1.s3. The basic biology of HER2

The basic biology of HER2

10.1093/annonc/12.suppl_1.s3

Crossref journal-article

Elsevier BV

Annals of Oncology (78)

Bibliography

Rubin, I., & Yarden, Y. (2001). The basic biology of HER2. Annals of Oncology, 12, S3âS8.

Authors 2

I. Rubin (first)
Y. Yarden (additional)

References 40 Referenced 332

10.1038/290261a0 / Nature / Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts by Shih (1981)
10.1126/science.2999974 / Science / Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene by Coussens (1985)
10.1126/science.2992089 / Science / Amplification of a novel v-erbB-related gene in a human mammary carcinoma by King (1985)
10.1016/0304-419X(94)90012-4 / Biochem Biophys Acta Rev Cancer / The biology of erbB-2/neu/HER-2 and its role in cancer by Hynes (1994)
{'key': '10.1093/annonc/12.suppl_1.S3_bb0030', 'series-title': 'Advances in Cancer Research', 'first-page': '25', 'article-title': 'Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors', 'author': 'Klapper', 'year': '2000'} / Advances in Cancer Research / Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors by Klapper (2000)
10.1126/science.3798106 / Science / Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene by Slamon (1987)
10.1002/stem.160413 / Stem Cells / The HER-2/neu oncogene in breast cancer: Prognostic factor, predictive factor, and target for therapy by Ross (1998)
{'key': '10.1093/annonc/12.suppl_1.S3_bb0045', 'first-page': 'M25', 'article-title': 'The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: From orphanhood to multiple stromal ligands', 'volume': '1377', 'author': 'Tzahar', 'year': '1998', 'journal-title': 'BBA Rev Cancer'} / BBA Rev Cancer / The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: From orphanhood to multiple stromal ligands by Tzahar (1998)
10.1146/annurev.cb.10.110194.001343 / Annu Rev Cell Biol / Receptor protein-kinases and their signal transduction pathways by van de Geer (1994)
10.1016/S0014-5793(97)00412-2 / FEBS Lett / The ErbB signaling network in embryogenesis and oncogenesis: Signal diversification through combinatorial ligand-receptor interactions by Alroy (1997)
10.1128/MCB.18.10.6090 / Mol Cell Biol / ErbB tyrosine kinases and the two neuregulin families constitute a ligand-receptor network by Pinkas-Kramarski (1998)
10.1002/j.1460-2075.1996.tb00603.x / EMBO J / Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions by Pinkas-Kramarski (1996)
10.1038/sj.onc.1201466 / Oncogene / Differential expression of NDF/neuregulin receptors ErbB-3 and ErbB-4 and involvement in inhibition of neuronal differentiation by Pinkas-Kramarski (1997)
{'key': '10.1093/annonc/12.suppl_1.S3_bb0075', 'first-page': '181A', 'article-title': 'Development and characterization of a rhuMAb HER2 antibody assay for clinical evaluation of cytotoxic potency', 'volume': '38', 'author': 'Baly', 'year': '1997', 'journal-title': 'Proc Am Assoc Cancer Res'} / Proc Am Assoc Cancer Res / Development and characterization of a rhuMAb HER2 antibody assay for clinical evaluation of cytotoxic potency by Baly (1997)
10.1016/S0896-6273(00)80324-4 / Neuron / Neuregulins and their receptors: A versatile signaling module in organogenesis and oncogenesis by Burden (1997)
10.1128/MCB.16.10.5276 / Mol Cell Biol / A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor by Tzahar (1996)
10.1093/emboj/17.20.5948 / EMBOJ / Pathogenic poxviruses reveal viral strategies to exploit the ErbB signaling network by Tzahar (1998)
10.1073/pnas.96.9.4995 / Proc Natl Acad Sci USA / The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-denved growth factors by Klapper (1999)
10.1093/emboj/16.16.4938 / EMBO J / Bivalence of EGF-like ligands drives the ErbB signaling network by Tzahar (1997)
10.1002/j.1460-2075.1996.tb00356.x / EMBOJ / ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: Implications for breast cancer by Karunagaren (1996)
10.1016/S0021-9258(17)36676-0 / J Biol Chem / Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin by Sliwkowski (1994)
10.1074/jbc.271.9.5251 / J Biol Chem / All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired by Baulida (1996)
10.1073/pnas.91.17.8132 / Proc Natl Acad Sci USA / Insect cell-expressed p180ErbB3 possesses an impaired tyrosine kinase activity by Guy (1994)
10.1093/emboj/18.12.3348 / EMBO J / The carboxyl terminus of the kinase-defective neuregulin receptor ErbB-3 confers mitogenic superiority and dictates endocytic routing by Waterman (1999)
10.1016/S0092-8674(85)80050-7 / Cell / Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies by Drebin (1985)
10.1073/pnas.88.19.8691 / Proc Natl Acad Sci USA / Mechanistic aspects of the opposing effects of monoclonal antibodies to the ERBB2 receptor on tumor growth by Stancovski (1991)
10.1073/pnas.92.8.3353 / Proc Natl Acad Sci USA / Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake by Hurwitz (1995)
{'key': '10.1093/annonc/12.suppl_1.S3_bb0145', 'first-page': '2771', 'article-title': 'Therapy of an animal model of human gastric cancer using a combination of anti-erbB-2 monoclonal antibodies', 'volume': '52', 'author': 'Kasprzyk', 'year': '1992', 'journal-title': 'Cancer Res'} / Cancer Res / Therapy of an animal model of human gastric cancer using a combination of anti-erbB-2 monoclonal antibodies by Kasprzyk (1992)
10.1046/j.1440-1711.1998.00768.x / Immunol Cell Biol / c-Cbl: A regulator of T-cell receptor-mediated signaling by Thien (1998)
10.1101/gad.12.23.3663 / Genes Dev / c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor by Levkowitz (1998)
{'key': '10.1093/annonc/12.suppl_1.S3_bb0160', 'first-page': '1117', 'article-title': 'Coupling of the c-Cbl protooncogene product to ErbB-1 /EGF-receptor but not to other ErbB proteins', 'volume': '12', 'author': 'Levkowitz', 'year': '1996', 'journal-title': 'Oncogene'} / Oncogene / Coupling of the c-Cbl protooncogene product to ErbB-1 /EGF-receptor but not to other ErbB proteins by Levkowitz (1996)
10.1016/S1097-2765(00)80231-2 / Mol Cell / Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl /Sli-1 by Levkowitz (1999)
10.1074/jbc.273.22.13819 / J Biol Chem / Alternative mtracellular routing of ErbB receptors may determine signaling potency by Waterman (1998)
{'key': '10.1093/annonc/12.suppl_1.S3_bb0175', 'first-page': '63', 'article-title': 'Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization', 'volume': '13', 'author': 'Pauletti', 'year': '1996', 'journal-title': 'Oncogene'} / Oncogene / Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization by Pauletti (1996)
10.1016/S0140-6736(87)92736-X / Lancet / Overexpression of the c-erbB-2 oncoprotein in human breast carcinomas: Immunohistological assessment correlates with gene amplification by Venter (1987)
10.1126/science.2470152 / Science / Studies of the HER-2/neu protooncogene in human breast and ovarian cancer by Slamon (1989)
10.1016/0046-8177(95)90163-9 / Hum Pathol / Neu overexpression correlates with extent of disease in large-cell ductal in situ carcinoma of the breast by De Potter (1995)
10.1073/pnas.89.10.4285 / Proc Natl Acad Sci USA / Humanization of the anti-p185HER2 antibody for human cancer therapy by Carter (1992)
{'key': '10.1093/annonc/12.suppl_1.S3_bb0200', 'first-page': '2825', 'article-title': 'Recombinant humanized anti-HER2 antibody (HerceptinTM) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts', 'volume': '58', 'author': 'Baselga', 'year': '1998', 'journal-title': 'Cancer Res'} / Cancer Res / Recombinant humanized anti-HER2 antibody (HerceptinTM) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts by Baselga (1998)
{'key': '10.1093/annonc/12.suppl_1.S3_bb0205', 'first-page': '1829', 'article-title': 'Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells', 'volume': '54', 'author': 'Pietras', 'year': '1994', 'journal-title': 'Oncogene'} / Oncogene / Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells by Pietras (1994)

Dates

Type	When
Created	13 years, 7 months ago (Jan. 20, 2012, 12:04 a.m.)
Deposited	3 years, 8 months ago (Dec. 26, 2021, 9:21 a.m.)
Indexed	3 weeks ago (Aug. 6, 2025, 9:55 a.m.)
Issued	24 years, 7 months ago (Jan. 1, 2001)
Published	24 years, 7 months ago (Jan. 1, 2001)
Published Print	24 years, 7 months ago (Jan. 1, 2001)

Funders 0

None

BibTeX

@article{Rubin_2001, title={The basic biology of HER2}, volume={12}, ISSN={0923-7534}, url={http://dx.doi.org/10.1093/annonc/12.suppl_1.s3}, DOI={10.1093/annonc/12.suppl_1.s3}, journal={Annals of Oncology}, publisher={Elsevier BV}, author={Rubin, I. and Yarden, Y.}, year={2001}, pages={S3–S8} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        6
      ]
    ],
    "date-time": "2025-08-06T13:55:51Z",
    "timestamp": 1754488551212
  },
  "reference-count": 40,
  "publisher": "Elsevier BV",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2001,
            1,
            1
          ]
        ],
        "date-time": "2001-01-01T00:00:00Z",
        "timestamp": 978307200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2019,
            12,
            24
          ]
        ],
        "date-time": "2019-12-24T00:00:00Z",
        "timestamp": 1577145600000
      },
      "content-version": "vor",
      "delay-in-days": 6931,
      "URL": "http://www.elsevier.com/open-access/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2001
      ]
    ]
  },
  "DOI": "10.1093/annonc/12.suppl_1.s3",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2012,
        1,
        20
      ]
    ],
    "date-time": "2012-01-20T05:04:11Z",
    "timestamp": 1327035851000
  },
  "page": "S3-S8",
  "source": "Crossref",
  "is-referenced-by-count": 332,
  "special_numbering": "S1",
  "title": "The basic biology of HER2",
  "prefix": "10.1016",
  "volume": "12",
  "author": [
    {
      "given": "I.",
      "family": "Rubin",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Y.",
      "family": "Yarden",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0010",
      "doi-asserted-by": "crossref",
      "first-page": "261",
      "DOI": "10.1038/290261a0",
      "article-title": "Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts",
      "volume": "290",
      "author": "Shih",
      "year": "1981",
      "journal-title": "Nature"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0015",
      "doi-asserted-by": "crossref",
      "first-page": "1132",
      "DOI": "10.1126/science.2999974",
      "article-title": "Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene",
      "volume": "230",
      "author": "Coussens",
      "year": "1985",
      "journal-title": "Science"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0020",
      "doi-asserted-by": "crossref",
      "first-page": "974",
      "DOI": "10.1126/science.2992089",
      "article-title": "Amplification of a novel v-erbB-related gene in a human mammary carcinoma",
      "volume": "229",
      "author": "King",
      "year": "1985",
      "journal-title": "Science"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0025",
      "doi-asserted-by": "crossref",
      "first-page": "165",
      "DOI": "10.1016/0304-419X(94)90012-4",
      "article-title": "The biology of erbB-2/neu/HER-2 and its role in cancer",
      "volume": "1198",
      "author": "Hynes",
      "year": "1994",
      "journal-title": "Biochem Biophys Acta Rev Cancer"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0030",
      "series-title": "Advances in Cancer Research",
      "first-page": "25",
      "article-title": "Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors",
      "author": "Klapper",
      "year": "2000"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0035",
      "doi-asserted-by": "crossref",
      "first-page": "177",
      "DOI": "10.1126/science.3798106",
      "article-title": "Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene",
      "volume": "235",
      "author": "Slamon",
      "year": "1987",
      "journal-title": "Science"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0040",
      "doi-asserted-by": "crossref",
      "first-page": "413",
      "DOI": "10.1002/stem.160413",
      "article-title": "The HER-2/neu oncogene in breast cancer: Prognostic factor, predictive factor, and target for therapy",
      "volume": "16",
      "author": "Ross",
      "year": "1998",
      "journal-title": "Stem Cells"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0045",
      "first-page": "M25",
      "article-title": "The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: From orphanhood to multiple stromal ligands",
      "volume": "1377",
      "author": "Tzahar",
      "year": "1998",
      "journal-title": "BBA Rev Cancer"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0050",
      "doi-asserted-by": "crossref",
      "first-page": "251",
      "DOI": "10.1146/annurev.cb.10.110194.001343",
      "article-title": "Receptor protein-kinases and their signal transduction pathways",
      "volume": "10",
      "author": "van de Geer",
      "year": "1994",
      "journal-title": "Annu Rev Cell Biol"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0055",
      "doi-asserted-by": "crossref",
      "first-page": "83",
      "DOI": "10.1016/S0014-5793(97)00412-2",
      "article-title": "The ErbB signaling network in embryogenesis and oncogenesis: Signal diversification through combinatorial ligand-receptor interactions",
      "volume": "410",
      "author": "Alroy",
      "year": "1997",
      "journal-title": "FEBS Lett"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0060",
      "doi-asserted-by": "crossref",
      "first-page": "6090",
      "DOI": "10.1128/MCB.18.10.6090",
      "article-title": "ErbB tyrosine kinases and the two neuregulin families constitute a ligand-receptor network",
      "volume": "18",
      "author": "Pinkas-Kramarski",
      "year": "1998",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0065",
      "doi-asserted-by": "crossref",
      "first-page": "2452",
      "DOI": "10.1002/j.1460-2075.1996.tb00603.x",
      "article-title": "Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions",
      "volume": "15",
      "author": "Pinkas-Kramarski",
      "year": "1996",
      "journal-title": "EMBO J"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0070",
      "doi-asserted-by": "crossref",
      "first-page": "2803",
      "DOI": "10.1038/sj.onc.1201466",
      "article-title": "Differential expression of NDF/neuregulin receptors ErbB-3 and ErbB-4 and involvement in inhibition of neuronal differentiation",
      "volume": "15",
      "author": "Pinkas-Kramarski",
      "year": "1997",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0075",
      "first-page": "181A",
      "article-title": "Development and characterization of a rhuMAb HER2 antibody assay for clinical evaluation of cytotoxic potency",
      "volume": "38",
      "author": "Baly",
      "year": "1997",
      "journal-title": "Proc Am Assoc Cancer Res"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0080",
      "doi-asserted-by": "crossref",
      "first-page": "847",
      "DOI": "10.1016/S0896-6273(00)80324-4",
      "article-title": "Neuregulins and their receptors: A versatile signaling module in organogenesis and oncogenesis",
      "volume": "18",
      "author": "Burden",
      "year": "1997",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0085",
      "doi-asserted-by": "crossref",
      "first-page": "5276",
      "DOI": "10.1128/MCB.16.10.5276",
      "article-title": "A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor",
      "volume": "16",
      "author": "Tzahar",
      "year": "1996",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0090",
      "doi-asserted-by": "crossref",
      "first-page": "5948",
      "DOI": "10.1093/emboj/17.20.5948",
      "article-title": "Pathogenic poxviruses reveal viral strategies to exploit the ErbB signaling network",
      "volume": "17",
      "author": "Tzahar",
      "year": "1998",
      "journal-title": "EMBOJ"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0095",
      "doi-asserted-by": "crossref",
      "first-page": "4995",
      "DOI": "10.1073/pnas.96.9.4995",
      "article-title": "The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-denved growth factors",
      "volume": "96",
      "author": "Klapper",
      "year": "1999",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0100",
      "doi-asserted-by": "crossref",
      "first-page": "4938",
      "DOI": "10.1093/emboj/16.16.4938",
      "article-title": "Bivalence of EGF-like ligands drives the ErbB signaling network",
      "volume": "16",
      "author": "Tzahar",
      "year": "1997",
      "journal-title": "EMBO J"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0105",
      "doi-asserted-by": "crossref",
      "first-page": "254",
      "DOI": "10.1002/j.1460-2075.1996.tb00356.x",
      "article-title": "ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: Implications for breast cancer",
      "volume": "15",
      "author": "Karunagaren",
      "year": "1996",
      "journal-title": "EMBOJ"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0110",
      "doi-asserted-by": "crossref",
      "first-page": "14661",
      "DOI": "10.1016/S0021-9258(17)36676-0",
      "article-title": "Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin",
      "volume": "269",
      "author": "Sliwkowski",
      "year": "1994",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0115",
      "doi-asserted-by": "crossref",
      "first-page": "5251",
      "DOI": "10.1074/jbc.271.9.5251",
      "article-title": "All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired",
      "volume": "271",
      "author": "Baulida",
      "year": "1996",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0120",
      "doi-asserted-by": "crossref",
      "first-page": "8132",
      "DOI": "10.1073/pnas.91.17.8132",
      "article-title": "Insect cell-expressed p180ErbB3 possesses an impaired tyrosine kinase activity",
      "volume": "91",
      "author": "Guy",
      "year": "1994",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0125",
      "doi-asserted-by": "crossref",
      "first-page": "3348",
      "DOI": "10.1093/emboj/18.12.3348",
      "article-title": "The carboxyl terminus of the kinase-defective neuregulin receptor ErbB-3 confers mitogenic superiority and dictates endocytic routing",
      "volume": "18",
      "author": "Waterman",
      "year": "1999",
      "journal-title": "EMBO J"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0130",
      "doi-asserted-by": "crossref",
      "first-page": "697",
      "DOI": "10.1016/S0092-8674(85)80050-7",
      "article-title": "Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies",
      "volume": "41",
      "author": "Drebin",
      "year": "1985",
      "journal-title": "Cell"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0135",
      "doi-asserted-by": "crossref",
      "first-page": "8691",
      "DOI": "10.1073/pnas.88.19.8691",
      "article-title": "Mechanistic aspects of the opposing effects of monoclonal antibodies to the ERBB2 receptor on tumor growth",
      "volume": "88",
      "author": "Stancovski",
      "year": "1991",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0140",
      "doi-asserted-by": "crossref",
      "first-page": "3353",
      "DOI": "10.1073/pnas.92.8.3353",
      "article-title": "Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake",
      "volume": "92",
      "author": "Hurwitz",
      "year": "1995",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0145",
      "first-page": "2771",
      "article-title": "Therapy of an animal model of human gastric cancer using a combination of anti-erbB-2 monoclonal antibodies",
      "volume": "52",
      "author": "Kasprzyk",
      "year": "1992",
      "journal-title": "Cancer Res"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0150",
      "doi-asserted-by": "crossref",
      "first-page": "473",
      "DOI": "10.1046/j.1440-1711.1998.00768.x",
      "article-title": "c-Cbl: A regulator of T-cell receptor-mediated signaling",
      "volume": "76",
      "author": "Thien",
      "year": "1998",
      "journal-title": "Immunol Cell Biol"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0155",
      "doi-asserted-by": "crossref",
      "first-page": "3663",
      "DOI": "10.1101/gad.12.23.3663",
      "article-title": "c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor",
      "volume": "12",
      "author": "Levkowitz",
      "year": "1998",
      "journal-title": "Genes Dev"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0160",
      "first-page": "1117",
      "article-title": "Coupling of the c-Cbl protooncogene product to ErbB-1 /EGF-receptor but not to other ErbB proteins",
      "volume": "12",
      "author": "Levkowitz",
      "year": "1996",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0165",
      "doi-asserted-by": "crossref",
      "first-page": "1029",
      "DOI": "10.1016/S1097-2765(00)80231-2",
      "article-title": "Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl /Sli-1",
      "volume": "4",
      "author": "Levkowitz",
      "year": "1999",
      "journal-title": "Mol Cell"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0170",
      "doi-asserted-by": "crossref",
      "first-page": "13819",
      "DOI": "10.1074/jbc.273.22.13819",
      "article-title": "Alternative mtracellular routing of ErbB receptors may determine signaling potency",
      "volume": "273",
      "author": "Waterman",
      "year": "1998",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0175",
      "first-page": "63",
      "article-title": "Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization",
      "volume": "13",
      "author": "Pauletti",
      "year": "1996",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0180",
      "doi-asserted-by": "crossref",
      "first-page": "69",
      "DOI": "10.1016/S0140-6736(87)92736-X",
      "article-title": "Overexpression of the c-erbB-2 oncoprotein in human breast carcinomas: Immunohistological assessment correlates with gene amplification",
      "volume": "ii",
      "author": "Venter",
      "year": "1987",
      "journal-title": "Lancet"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0185",
      "doi-asserted-by": "crossref",
      "first-page": "707",
      "DOI": "10.1126/science.2470152",
      "article-title": "Studies of the HER-2/neu protooncogene in human breast and ovarian cancer",
      "volume": "244",
      "author": "Slamon",
      "year": "1989",
      "journal-title": "Science"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0190",
      "doi-asserted-by": "crossref",
      "first-page": "601",
      "DOI": "10.1016/0046-8177(95)90163-9",
      "article-title": "Neu overexpression correlates with extent of disease in large-cell ductal in situ carcinoma of the breast",
      "volume": "26",
      "author": "De Potter",
      "year": "1995",
      "journal-title": "Hum Pathol"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0195",
      "doi-asserted-by": "crossref",
      "first-page": "4285",
      "DOI": "10.1073/pnas.89.10.4285",
      "article-title": "Humanization of the anti-p185HER2 antibody for human cancer therapy",
      "volume": "89",
      "author": "Carter",
      "year": "1992",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0200",
      "first-page": "2825",
      "article-title": "Recombinant humanized anti-HER2 antibody (HerceptinTM) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts",
      "volume": "58",
      "author": "Baselga",
      "year": "1998",
      "journal-title": "Cancer Res"
    },
    {
      "key": "10.1093/annonc/12.suppl_1.S3_bb0205",
      "first-page": "1829",
      "article-title": "Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells",
      "volume": "54",
      "author": "Pietras",
      "year": "1994",
      "journal-title": "Oncogene"
    }
  ],
  "container-title": "Annals of Oncology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0923753419544556?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0923753419544556?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://academic.oup.com/annonc/article-pdf/12/suppl_1/S3/6672767/12-suppl_1-S3.pdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        12,
        26
      ]
    ],
    "date-time": "2021-12-26T14:21:07Z",
    "timestamp": 1640528467000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0923753419544556"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2001
      ]
    ]
  },
  "references-count": 40,
  "alternative-id": [
    "S0923753419544556"
  ],
  "URL": "http://dx.doi.org/10.1093/annonc/12.suppl_1.S3",
  "relation": {},
  "ISSN": [
    "0923-7534"
  ],
  "subject": [],
  "container-title-short": "Annals of Oncology",
  "published": {
    "date-parts": [
      [
        2001
      ]
    ]
  }
}