DOI: 10.1093/ajcn/54.6.1119s. Action of ascorbic acid as a scavenger of active and stable oxygen radicals

Action of ascorbic acid as a scavenger of active and stable oxygen radicals

10.1093/ajcn/54.6.1119s

Crossref journal-article

Elsevier BV

The American Journal of Clinical Nutrition (78)

Bibliography

Niki, E. (1991). Action of ascorbic acid as a scavenger of active and stable oxygen radicals. The American Journal of Clinical Nutrition, 54(6), 1119S-1124S.

Authors 1

E Niki (first)

References 55 Referenced 341

{'volume': 'I-VI', 'article-title': 'Free radicals in biology', 'year': '1976', 'key': '10.1093/ajcn/54.6.1119s_bib1'} / Free radicals in biology (1976)
{'year': '1989', 'series-title': 'Free radicals in biology and medicine', 'author': 'Halliwell', 'key': '10.1093/ajcn/54.6.1119s_bib2'} / Free radicals in biology and medicine by Halliwell (1989)
{'year': '1985', 'series-title': 'Oxidative stress', 'author': 'Sies', 'key': '10.1093/ajcn/54.6.1119s_bib3'} / Oxidative stress by Sies (1985)
{'key': '10.1093/ajcn/54.6.1119s_bib4', 'first-page': '122', 'article-title': 'Metabolism and function of ascorbic acid and its metabolites', 'volume': '27', 'author': 'Tolbert', 'year': '1985', 'journal-title': 'Int J Vitam Nutr Res'} / Int J Vitam Nutr Res / Metabolism and function of ascorbic acid and its metabolites by Tolbert (1985)
10.1056/NEJM198604033141407 / N Engl J Med / New concepts in the biology and biochemistry of ascorbic acid by Levine (1986)
10.1016/S8755-9668(86)80021-7 / Adv Free Radic Biol Med / The antioxidant role of vitamin C by Bendich (1986)
{'key': '10.1093/ajcn/54.6.1119s_bib7', 'first-page': '1', 'article-title': 'Third conference on vitamin C', 'volume': '498', 'author': 'Bums', 'year': '1987', 'journal-title': 'Ann N Y Acad Sci'} / Ann N Y Acad Sci / Third conference on vitamin C by Bums (1987)
{'key': '10.1093/ajcn/54.6.1119s_bib8', 'first-page': '1', 'article-title': 'Vitamin C as an antioxidant', 'volume': '64', 'author': 'Niki', 'year': '1990', 'journal-title': 'World Rev Nutr Diet'} / World Rev Nutr Diet / Vitamin C as an antioxidant by Niki (1990)
10.3177/jnsv.32.475 / J Nutr Sci Vitaminol (Tokyo) / Free radical chain oxidation and hemolysis of erythrocytes by molecular oxygen and their inhibition by vitamin E by Yamamoto (1986)
10.1016/0003-9861(87)90358-4 / Arch Biochem Biophys / Free-radical chain oxidation of rat red blood cells by molecular oxygen and its inhibition by α-tocopherol by Miki (1987)
10.3109/10715769009148569 / Free Radic Res Commun / How to characterize a biological antioxidant by Halliwell (1990)
10.1073/pnas.78.11.6858 / Proc Natl Acad Sci USA / Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer a hypothesis by Ames (1981)
{'key': '10.1093/ajcn/54.6.1119s_bib13', 'series-title': 'Lipid peroxidation in biological systems', 'first-page': '32', 'article-title': 'Lipid peroxidation in biological systems', 'author': 'Niki', 'year': '1988'} / Lipid peroxidation in biological systems / Lipid peroxidation in biological systems by Niki (1988)
{'key': '10.1093/ajcn/54.6.1119s_bib14', 'first-page': '254', 'article-title': 'The role of vitamin E and carotenoids in preventing oxidation of low density lipoprotein', 'author': 'Esterbauer', 'year': '1981', 'journal-title': 'Ann NY Acad Sci'} / Ann NY Acad Sci / The role of vitamin E and carotenoids in preventing oxidation of low density lipoprotein by Esterbauer (1981)
10.1016/0304-4165(87)90155-3 / Biochim Biophys Acta / The relative contributions of vitamin E, urate, ascorbic acid and proteins to the total peroxyl radical-trapping antioxidant in human blood plasma by Wayner (1987)
{'key': '10.1093/ajcn/54.6.1119s_bib16', 'first-page': '5918', 'article-title': 'Antioxidant activity of albumin-bound bilirubin Proc Natl Acad Sci USA', 'volume': '84', 'author': 'Stocker', 'year': '1987'} / Antioxidant activity of albumin-bound bilirubin Proc Natl Acad Sci USA by Stocker (1987)
10.3177/jnsv.34.507 / J Nutr Sci Vi> taminol (Tokyo) / Free radical-mediated damage of blood and its inhibition by antioxidants by Niki (1988)
10.1016/0003-9861(90)90508-V / Arch Biochem Biophys / Free radical-mediated chain oxidation of low density lipoprotein and its synergistic inhibition by vitamin E and vitamin C by Sato (1990)
10.1073/pnas.85.24.9748 / Proc Natl Acad Sci USA / Antioxidant defenses and lipid peroxidation in human blood plasma by Frei (1988)
10.1073/pnas.86.16.6377 / Proc Natl Acad Sci USA / Ascorbate is an outstanding antioxidant in human blood plasma by Frei (1989)
10.1246/bcsj.57.1260 / Bull Chem Soc Japan / Oxidation of methyl linoleate in aqueous dispersion by Yamamoto (1984)
10.1016/0009-3084(87)90052-1 / Chem Phys Lipids / Antioxidants in relation to lipid peroxidation by Niki (1987)
10.1021/ar00127a001 / Accounts Chem Res / Vitamin E: application of the principles of physical organic chemistry to the exploration of its structure and function by Burton (1986)
10.1146/annurev.nu.05.070185.001543 / Annu Rev Nutr / Vitamin E: interactions with free radicals and ascorbate by McCay (1985)
10.1111/j.1749-6632.1987.tb23761.x / Ann N Y Acad Sci / Interaction of ascorbate and α-tocopherol by Niki (1987)
{'key': '10.1093/ajcn/54.6.1119s_bib26', 'first-page': '199', 'article-title': 'Interaction of vitamin E and ascorbic acid', 'volume': '3', 'author': 'Chen', 'year': '1989', 'journal-title': 'In Vivo'} / In Vivo / Interaction of vitamin E and ascorbic acid by Chen (1989)
10.1038/278737a0 / Nature / Direct observation of a free radical interaction between vitamin E and vitamin C by Packer (1979)
10.1246/cl.1982.789 / Chem Lett / Regeneration of vitamin E from α-chromanoxy radical by glutathione and vitamin C by Niki (1982)
10.1016/S0021-9258(17)43026-2 / J Biol Chem / Inhibition of oxidation of methyl linoleate in solution by vitamin E and vitamin C by Niki (1984)
10.1016/0005-2760(81)90049-7 / Biochim Biophys Acta / The cooperative interaction between vitamin E and vitamin C in suppression of peroxidation of membrane phospholipids by Leung (1981)
10.1016/0304-4165(84)90070-9 / Biochim Biophys Acte / Formation of a-tocopherol radical and recycling of α-tocopherol by ascorbate during peroxidation of phosphatidylcholine liposomes by Scarpa (1984)
10.1016/0009-3084(83)90022-1 / Chem Phys Lipids / Electron spin resonance study of the role of vitamin E and vitamin C in the inhibition of fatty acid oxidation in a model membrane by Bascetta (1983)
10.1246/bcsj.58.1971 / Bull Chem Soc Japan / Synergistic inhibition of oxidation of vitamin E and vitamin C by Niki (1985)
{'key': '10.1093/ajcn/54.6.1119s_bib34', 'first-page': '298', 'article-title': 'Antioxidant and co-antioxidant activity of vitamin C', 'volume': '835', 'author': 'Doha', 'year': '1985', 'journal-title': 'The effect of vitamin C, either alone or in the presence of vitamin E or a water-soluble vitamin E analogue, upon the peroxidation of aqueous multilamellar phospholipid liposomes. Biochim Biophys Acte'} / The effect of vitamin C, either alone or in the presence of vitamin E or a water-soluble vitamin E analogue, upon the peroxidation of aqueous multilamellar phospholipid liposomes. Biochim Biophys Acte / Antioxidant and co-antioxidant activity of vitamin C by Doha (1985)
{'key': '10.1093/ajcn/54.6.1119s_bib35', 'first-page': '12114', 'article-title': 'Antioxidant protection of phospholipid bilayers by α-tocopherol', 'volume': '261', 'author': 'Liebier', 'year': '1986', 'journal-title': 'J Biol Chem'} / J Biol Chem / Antioxidant protection of phospholipid bilayers by α-tocopherol by Liebier (1986)
10.1111/j.1432-1033.1988.tb14105.x / Eur J Biochem / The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E by Wefers (1988)
10.1111/j.1749-6632.1989.tb14961.x / Ann N Y Acad Sci / Synergistic inhibition of oxidation in RBC ghosts by vitamins C and E by Miki (1989)
{'key': '10.1093/ajcn/54.6.1119s_bib38', 'first-page': '1288', 'article-title': 'The autoxidation of unsaturated lipids in micelles', 'volume': '61', 'author': 'Barclay', 'year': '1983', 'journal-title': 'Synergism of inhibitors vitamins C and E. Can J Chem'} / Synergism of inhibitors vitamins C and E. Can J Chem / The autoxidation of unsaturated lipids in micelles by Barclay (1983)
10.1016/0003-9861(89)90548-1 / Arch Biochem Biophys / Synergistic inhibition of oxidation in dispersed phosphatidylcholine liposomes by a combination of vitamin E and cysteine by Motoyama (1989)
10.1246/bcsj.58.326 / Bull Chem Soc Japan / Interaction of galvinoxyl radical with ascorbic acid, cysteine and glutathione in homogeneous solution and in aqueous dispersions by Tsuchiya (1985)
10.3177/jnsv.34.25 / J Nutr Sci Vitaminol (Tokyo) / Action of vitamin E as antioxidant in phospholipid liposomal membranes as studied by spin label technique by Takahashi (1988)
10.1021/jo00177a021 / J Org Chem / Products and stoichiometry of reaction of vitamin E with alkylperoxy radicals by Winterle (1984)
10.1021/ja00200a042 / J Am Chem Soc / Radical-scavenging reactions of vitamin E and its model compound, 2,2,5,7,8-pentame- thylchroman-6-ol, in a tert-butylperoxyl radical-generating system by Matsuo (1989)
10.1007/BF02544330 / Lipids / Reaction products of α- tocopherol with methyl linoleate-peroxyl radicals by Yamauchi (1990)
10.1021/bi00451a034 / Biochem / Redox cycles of vitamin E: hydrolysis and ascorbic acid dependent reduction of 8a-(alkyldioxy) tocopherones by Liebier (1989)
{'key': '10.1093/ajcn/54.6.1119s_bib46', 'first-page': '2855', 'article-title': 'Reaction of 8a-hydroperoxy to- copherones with ascorbic acid', 'volume': '45', 'author': 'Yamauchi', 'year': '1981', 'journal-title': 'Agric Biol Chem'} / Agric Biol Chem / Reaction of 8a-hydroperoxy to- copherones with ascorbic acid by Yamauchi (1981)
10.1016/0003-9861(75)90165-4 / Arch Biochem Biophys / Oxidation of α-tocopherol model compound by superoxide anion by Nishikimi (1975)
10.1093/jn/114.9.1588 / J Nutr / Interaction of dietary vitamin C and vitamin E on guinea pig immune responses to mitogens by Bendich (1984)
{'key': '10.1093/ajcn/54.6.1119s_bib49', 'first-page': '71', 'article-title': 'Effect of dietary vitamin C and vitamin E on tissue lipid peroxidation of guinea pigs fed with oxidized oil', 'volume': '50', 'author': 'Miyazawa', 'year': '1986', 'journal-title': 'Agric Biol Chem'} / Agric Biol Chem / Effect of dietary vitamin C and vitamin E on tissue lipid peroxidation of guinea pigs fed with oxidized oil by Miyazawa (1986)
10.1007/BF01955766 / Experientia / The effect of chronic marginal vitamin C deficiency on the alpha-tocopherol content of the organs and plasma of guinea-pigs by Hruba (1982)
{'key': '10.1093/ajcn/54.6.1119s_bib51', 'first-page': '199', 'article-title': 'Biokinetics of dietary RRR-α-tocopherol in the male guinea pig at three dietary levels of vitamin C and two levels of vitamin E', 'volume': '25', 'author': 'Burton', 'year': '1990', 'journal-title': 'Evidence that vitamin C does not ““spare”“ vitamin E in vivo. Lipids'} / Evidence that vitamin C does not ““spare”“ vitamin E in vivo. Lipids / Biokinetics of dietary RRR-α-tocopherol in the male guinea pig at three dietary levels of vitamin C and two levels of vitamin E by Burton (1990)
{'key': '10.1093/ajcn/54.6.1119s_bib52', 'first-page': '114952', 'article-title': 'Role of iron and ascorbic add in the oxidation of methyl linoleate micelles', 'author': 'Yamamoto', 'year': '1987', 'journal-title': 'Chem Lett'} / Chem Lett / Role of iron and ascorbic add in the oxidation of methyl linoleate micelles by Yamamoto (1987)
10.1093/ajcn/54.6.1129s / Am J Gin Nutr / Serum urate as an antioxidant for ascorbic add by Sevanian (1991)
10.1016/0304-4165(86)90234-5 / Biochim Biophys Acta / The antioxidant efficiency of vitamin C is concentration-dependent by Wayner (1986)
10.1016/0014-4835(84)90142-8 / Exp Eye Res / A direct correlation between the levels of ascorbic add and H2O2 in aqueous humor by Giblin (1984)

Dates

Type	When
Created	7 years, 8 months ago (Jan. 5, 2018, 10:46 a.m.)
Deposited	1 year, 2 months ago (June 14, 2024, 7:37 p.m.)
Indexed	2 weeks, 4 days ago (Aug. 19, 2025, 6:11 a.m.)
Issued	33 years, 9 months ago (Dec. 1, 1991)
Published	33 years, 9 months ago (Dec. 1, 1991)
Published Print	33 years, 9 months ago (Dec. 1, 1991)

Funders 0

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BibTeX

@article{Niki_1991, title={Action of ascorbic acid as a scavenger of active and stable oxygen radicals}, volume={54}, ISSN={0002-9165}, url={http://dx.doi.org/10.1093/ajcn/54.6.1119s}, DOI={10.1093/ajcn/54.6.1119s}, number={6}, journal={The American Journal of Clinical Nutrition}, publisher={Elsevier BV}, author={Niki, E}, year={1991}, month=dec, pages={1119S-1124S} }

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      "article-title": "Third conference on vitamin C",
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      "author": "McCay",
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      "first-page": "199",
      "article-title": "Interaction of vitamin E and ascorbic acid",
      "volume": "3",
      "author": "Chen",
      "year": "1989",
      "journal-title": "In Vivo"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "737",
      "DOI": "10.1038/278737a0",
      "article-title": "Direct observation of a free radical interaction between vitamin E and vitamin C",
      "volume": "278",
      "author": "Packer",
      "year": "1979",
      "journal-title": "Nature"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "789",
      "DOI": "10.1246/cl.1982.789",
      "article-title": "Regeneration of vitamin E from \u03b1-chromanoxy radical by glutathione and vitamin C",
      "author": "Niki",
      "year": "1982",
      "journal-title": "Chem Lett"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "4177",
      "DOI": "10.1016/S0021-9258(17)43026-2",
      "article-title": "Inhibition of oxidation of methyl linoleate in solution by vitamin E and vitamin C",
      "volume": "259",
      "author": "Niki",
      "year": "1984",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "266",
      "DOI": "10.1016/0005-2760(81)90049-7",
      "article-title": "The cooperative interaction between vitamin E and vitamin C in suppression of peroxidation of membrane phospholipids",
      "volume": "664",
      "author": "Leung",
      "year": "1981",
      "journal-title": "Biochim Biophys Acta"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "215",
      "DOI": "10.1016/0304-4165(84)90070-9",
      "article-title": "Formation of a-tocopherol radical and recycling of \u03b1-tocopherol by ascorbate during peroxidation of phosphatidylcholine liposomes",
      "volume": "801",
      "author": "Scarpa",
      "year": "1984",
      "journal-title": "Biochim Biophys Acte"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "20710",
      "DOI": "10.1016/0009-3084(83)90022-1",
      "article-title": "Electron spin resonance study of the role of vitamin E and vitamin C in the inhibition of fatty acid oxidation in a model membrane",
      "volume": "33",
      "author": "Bascetta",
      "year": "1983",
      "journal-title": "Chem Phys Lipids"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "1971",
      "DOI": "10.1246/bcsj.58.1971",
      "article-title": "Synergistic inhibition of oxidation of vitamin E and vitamin C",
      "volume": "58",
      "author": "Niki",
      "year": "1985",
      "journal-title": "Bull Chem Soc Japan"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib34",
      "first-page": "298",
      "article-title": "Antioxidant and co-antioxidant activity of vitamin C",
      "volume": "835",
      "author": "Doha",
      "year": "1985",
      "journal-title": "The effect of vitamin C, either alone or in the presence of vitamin E or a water-soluble vitamin E analogue, upon the peroxidation of aqueous multilamellar phospholipid liposomes. Biochim Biophys Acte"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib35",
      "first-page": "12114",
      "article-title": "Antioxidant protection of phospholipid bilayers by \u03b1-tocopherol",
      "volume": "261",
      "author": "Liebier",
      "year": "1986",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "353",
      "DOI": "10.1111/j.1432-1033.1988.tb14105.x",
      "article-title": "The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E",
      "volume": "174",
      "author": "Wefers",
      "year": "1988",
      "journal-title": "Eur J Biochem"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "474",
      "DOI": "10.1111/j.1749-6632.1989.tb14961.x",
      "article-title": "Synergistic inhibition of oxidation in RBC ghosts by vitamins C and E",
      "volume": "570",
      "author": "Miki",
      "year": "1989",
      "journal-title": "Ann N Y Acad Sci"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib38",
      "first-page": "1288",
      "article-title": "The autoxidation of unsaturated lipids in micelles",
      "volume": "61",
      "author": "Barclay",
      "year": "1983",
      "journal-title": "Synergism of inhibitors vitamins C and E. Can J Chem"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "655",
      "DOI": "10.1016/0003-9861(89)90548-1",
      "article-title": "Synergistic inhibition of oxidation in dispersed phosphatidylcholine liposomes by a combination of vitamin E and cysteine",
      "volume": "270",
      "author": "Motoyama",
      "year": "1989",
      "journal-title": "Arch Biochem Biophys"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "326",
      "DOI": "10.1246/bcsj.58.326",
      "article-title": "Interaction of galvinoxyl radical with ascorbic acid, cysteine and glutathione in homogeneous solution and in aqueous dispersions",
      "volume": "58",
      "author": "Tsuchiya",
      "year": "1985",
      "journal-title": "Bull Chem Soc Japan"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "25",
      "DOI": "10.3177/jnsv.34.25",
      "article-title": "Action of vitamin E as antioxidant in phospholipid liposomal membranes as studied by spin label technique",
      "volume": "34",
      "author": "Takahashi",
      "year": "1988",
      "journal-title": "J Nutr Sci Vitaminol (Tokyo)"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "491",
      "DOI": "10.1021/jo00177a021",
      "article-title": "Products and stoichiometry of reaction of vitamin E with alkylperoxy radicals",
      "volume": "49",
      "author": "Winterle",
      "year": "1984",
      "journal-title": "J Org Chem"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "7179",
      "DOI": "10.1021/ja00200a042",
      "article-title": "Radical-scavenging reactions of vitamin E and its model compound, 2,2,5,7,8-pentame- thylchroman-6-ol, in a tert-butylperoxyl radical-generating system",
      "volume": "111",
      "author": "Matsuo",
      "year": "1989",
      "journal-title": "J Am Chem Soc"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "152",
      "DOI": "10.1007/BF02544330",
      "article-title": "Reaction products of \u03b1- tocopherol with methyl linoleate-peroxyl radicals",
      "volume": "25",
      "author": "Yamauchi",
      "year": "1990",
      "journal-title": "Lipids"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "9772",
      "DOI": "10.1021/bi00451a034",
      "article-title": "Redox cycles of vitamin E: hydrolysis and ascorbic acid dependent reduction of 8a-(alkyldioxy) tocopherones",
      "volume": "28",
      "author": "Liebier",
      "year": "1989",
      "journal-title": "Biochem"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib46",
      "first-page": "2855",
      "article-title": "Reaction of 8a-hydroperoxy to- copherones with ascorbic acid",
      "volume": "45",
      "author": "Yamauchi",
      "year": "1981",
      "journal-title": "Agric Biol Chem"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "6849",
      "DOI": "10.1016/0003-9861(75)90165-4",
      "article-title": "Oxidation of \u03b1-tocopherol model compound by superoxide anion",
      "volume": "170",
      "author": "Nishikimi",
      "year": "1975",
      "journal-title": "Arch Biochem Biophys"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "1588",
      "DOI": "10.1093/jn/114.9.1588",
      "article-title": "Interaction of dietary vitamin C and vitamin E on guinea pig immune responses to mitogens",
      "volume": "114",
      "author": "Bendich",
      "year": "1984",
      "journal-title": "J Nutr"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib49",
      "first-page": "71",
      "article-title": "Effect of dietary vitamin C and vitamin E on tissue lipid peroxidation of guinea pigs fed with oxidized oil",
      "volume": "50",
      "author": "Miyazawa",
      "year": "1986",
      "journal-title": "Agric Biol Chem"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "1454",
      "DOI": "10.1007/BF01955766",
      "article-title": "The effect of chronic marginal vitamin C deficiency on the alpha-tocopherol content of the organs and plasma of guinea-pigs",
      "volume": "38",
      "author": "Hruba",
      "year": "1982",
      "journal-title": "Experientia"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib51",
      "first-page": "199",
      "article-title": "Biokinetics of dietary RRR-\u03b1-tocopherol in the male guinea pig at three dietary levels of vitamin C and two levels of vitamin E",
      "volume": "25",
      "author": "Burton",
      "year": "1990",
      "journal-title": "Evidence that vitamin C does not \u201c\u201cspare\u201d\u201c vitamin E in vivo. Lipids"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib52",
      "first-page": "114952",
      "article-title": "Role of iron and ascorbic add in the oxidation of methyl linoleate micelles",
      "author": "Yamamoto",
      "year": "1987",
      "journal-title": "Chem Lett"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib53",
      "doi-asserted-by": "crossref",
      "first-page": "1129S",
      "DOI": "10.1093/ajcn/54.6.1129s",
      "article-title": "Serum urate as an antioxidant for ascorbic add",
      "volume": "54",
      "author": "Sevanian",
      "year": "1991",
      "journal-title": "Am J Gin Nutr"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib54",
      "doi-asserted-by": "crossref",
      "first-page": "119",
      "DOI": "10.1016/0304-4165(86)90234-5",
      "article-title": "The antioxidant efficiency of vitamin C is concentration-dependent",
      "volume": "884",
      "author": "Wayner",
      "year": "1986",
      "journal-title": "Biochim Biophys Acta"
    },
    {
      "key": "10.1093/ajcn/54.6.1119s_bib55",
      "doi-asserted-by": "crossref",
      "first-page": "87",
      "DOI": "10.1016/0014-4835(84)90142-8",
      "article-title": "A direct correlation between the levels of ascorbic add and H2O2 in aqueous humor",
      "volume": "38",
      "author": "Giblin",
      "year": "1984",
      "journal-title": "Exp Eye Res"
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