DOI: 10.1091/mbc.e17-05-0333. A deep learning and novelty detection framework for rapid phenotyping in high-content screening

A deep learning and novelty detection framework for rapid phenotyping in high-content screening

10.1091/mbc.e17-05-0333

Crossref journal-article

American Society for Cell Biology (ASCB)

Molecular Biology of the Cell (1076)

Abstract

Supervised machine learning is a powerful and widely used method for analyzing high-content screening data. Despite its accuracy, efficiency, and versatility, supervised machine learning has drawbacks, most notably its dependence on a priori knowledge of expected phenotypes and time-consuming classifier training. We provide a solution to these limitations with CellCognition Explorer, a generic novelty detection and deep learning framework. Application to several large-scale screening data sets on nuclear and mitotic cell morphologies demonstrates that CellCognition Explorer enables discovery of rare phenotypes without user training, which has broad implications for improved assay development in high-content screening.

Bibliography

Sommer, C., Hoefler, R., Samwer, M., & Gerlich, D. W. (2017). A deep learning and novelty detection framework for rapid phenotyping in high-content screening. Molecular Biology of the Cell, 28(23), 3428â3436.

Authors 4

Christoph Sommer (first)
Rudolf Hoefler (additional)
Matthias Samwer (additional)
Daniel W. Gerlich (additional)

References 46 Referenced 85

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Dates

Type	When
Created	7 years, 10 months ago (Sept. 27, 2017, 8:50 p.m.)
Deposited	6 years, 1 month ago (July 14, 2019, 12:32 p.m.)
Indexed	1 month, 1 week ago (July 11, 2025, 9:18 p.m.)
Issued	7 years, 9 months ago (Nov. 7, 2017)
Published	7 years, 9 months ago (Nov. 7, 2017)
Published Print	7 years, 9 months ago (Nov. 7, 2017)

Funders 0

None

BibTeX

@article{Sommer_2017, title={A deep learning and novelty detection framework for rapid phenotyping in high-content screening}, volume={28}, ISSN={1939-4586}, url={http://dx.doi.org/10.1091/mbc.e17-05-0333}, DOI={10.1091/mbc.e17-05-0333}, number={23}, journal={Molecular Biology of the Cell}, publisher={American Society for Cell Biology (ASCB)}, author={Sommer, Christoph and Hoefler, Rudolf and Samwer, Matthias and Gerlich, Daniel W.}, editor={Boone, Charles}, year={2017}, month=nov, pages={3428–3436} }

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    }
  },
  "alternative-id": [
    "10.1091/mbc.e17-05-0333"
  ],
  "URL": "http://dx.doi.org/10.1091/mbc.e17-05-0333",
  "relation": {},
  "ISSN": [
    "1059-1524",
    "1939-4586"
  ],
  "subject": [],
  "container-title-short": "MBoC",
  "published": {
    "date-parts": [
      [
        2017,
        11,
        7
      ]
    ]
  }
}