DOI: 10.1091/mbc.e11-09-0761. The C-terminal domain of Nup93 is essential for assembly of the structural backbone of nuclear pore complexes

The C-terminal domain of Nup93 is essential for assembly of the structural backbone of nuclear pore complexes

10.1091/mbc.e11-09-0761

Crossref journal-article

American Society for Cell Biology (ASCB)

Molecular Biology of the Cell (1076)

Abstract

Nuclear pore complexes (NPCs) are large macromolecular assemblies that control all transport across the nuclear envelope. They are formed by about 30 nucleoporins (Nups), which can be roughly categorized into those forming the structural skeleton of the pore and those creating the central channel and thus providing the transport and gating properties of the NPC. Here we show that the conserved nucleoporin Nup93 is essential for NPC assembly and connects both portions of the NPC. Although the C-terminal domain of the protein is necessary and sufficient for the assembly of a minimal structural backbone, full-length Nup93 is required for the additional recruitment of the Nup62 complex and the establishment of transport-competent NPCs.

Bibliography

Sachdev, R., Sieverding, C., FlÃ¶tenmeyer, M., & Antonin, W. (2012). The C-terminal domain of Nup93 is essential for assembly of the structural backbone of nuclear pore complexes. Molecular Biology of the Cell, 23(4), 740â749.

Authors 4

Ruchika Sachdev (first)
Cornelia Sieverding (additional)
Matthias Flötenmeyer (additional)
Wolfram Antonin (additional)

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Dates

Type	When
Created	13 years, 8 months ago (Dec. 14, 2011, 10:56 p.m.)
Deposited	6 years, 1 month ago (July 14, 2019, 9:25 a.m.)
Indexed	1 month, 2 weeks ago (July 11, 2025, 6:53 a.m.)
Issued	13 years, 6 months ago (Feb. 15, 2012)
Published	13 years, 6 months ago (Feb. 15, 2012)
Published Print	13 years, 6 months ago (Feb. 15, 2012)

Funders 0

None

BibTeX

@article{Sachdev_2012, title={The C-terminal domain of Nup93 is essential for assembly of the structural backbone of nuclear pore complexes}, volume={23}, ISSN={1939-4586}, url={http://dx.doi.org/10.1091/mbc.e11-09-0761}, DOI={10.1091/mbc.e11-09-0761}, number={4}, journal={Molecular Biology of the Cell}, publisher={American Society for Cell Biology (ASCB)}, author={Sachdev, Ruchika and Sieverding, Cornelia and Flötenmeyer, Matthias and Antonin, Wolfram}, editor={Hetzer, Martin}, year={2012}, month=feb, pages={740–749} }

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